Bhimamycin J, a Rare Benzo[f]isoindole-dione Alkaloid from the Marine-Derived Actinomycete Streptomyces sp. MS180069
© 2021 Wiley-VHCA AG, Zurich, Switzerland..
Chemical investigation on a Streptomyces sp. strain MS180069 isolated from a sediment sample collected from the South China Sea, yielded the new benzo[f]isoindole-dione alkaloid, bhimamycin J (1). The structure was determined by extensive spectroscopic analysis, including HRMS, 1D, 2D NMR, and X-ray diffraction techniques. A molecular docking study revealed 1 as a new molecular motif that binds with human angiotensin converting enzyme2 (ACE2), recently described as the cell surface receptor responsible for uptake of 2019-CoV-2. Using enzyme assays we confirm that 1 inhibits human ACE2 79.7 % at 25 μg/mL.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:18 |
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| Enthalten in: |
Chemistry & biodiversity - 18(2021), 11 vom: 01. Nov., Seite e2100674 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Song, Fuhang [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 18.11.2021 Date Revised 07.12.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/cbdv.202100674 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM33150295X |
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| 520 | |a © 2021 Wiley-VHCA AG, Zurich, Switzerland. | ||
| 520 | |a Chemical investigation on a Streptomyces sp. strain MS180069 isolated from a sediment sample collected from the South China Sea, yielded the new benzo[f]isoindole-dione alkaloid, bhimamycin J (1). The structure was determined by extensive spectroscopic analysis, including HRMS, 1D, 2D NMR, and X-ray diffraction techniques. A molecular docking study revealed 1 as a new molecular motif that binds with human angiotensin converting enzyme2 (ACE2), recently described as the cell surface receptor responsible for uptake of 2019-CoV-2. Using enzyme assays we confirm that 1 inhibits human ACE2 79.7 % at 25 μg/mL | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a bhimamycin J | |
| 650 | 4 | |a marine-derived actinomycete | |
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| 700 | 1 | |a Khalil, Zeinab G |e verfasserin |4 aut | |
| 700 | 1 | |a Salim, Angela A |e verfasserin |4 aut | |
| 700 | 1 | |a Han, Jiahui |e verfasserin |4 aut | |
| 700 | 1 | |a Bernhardt, Paul V |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Rui |e verfasserin |4 aut | |
| 700 | 1 | |a Xu, Xiuli |e verfasserin |4 aut | |
| 700 | 1 | |a Capon, Robert J |e verfasserin |4 aut | |
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