SARS-CoV-2 infection pattern, transmission and treatment : Multi-center study in low to middle-income districts hospitals in Punjab, Pakistan
Pakistan has reported a substantial number of COVID-19 cases since 2020. A multicenter observational study was conducted to identify the pattern of SARS-CoV-2 infection, transmission, and treatment in patients admitted to seven low to middle-income district hospitals in the Province of Punjab, Pakistan from March to June 2020. A total of 102 patients were recruited. 57 patients tested positive and 45 developed moderate-severe COVID-19 disease. About 67% of the patients in March-April and 93% in May-June have contracted the disease from the local transmission. The mean number of symptoms in SARS-CoV-2 positive patients was significantly higher than suspected patients (6.46 vs 5.04, p=0.003). The number of deaths was low (n=8) with 86% recovery rate. Mild COVID patients received acetaminophen (n=102), azithromycin (n=8), and hydroxychloroquine (n=4) in addition to standard medical care. The treatment provided to moderate-severe cases included acetaminophen (45/45), azithromycin (45/45), Ivermectin (14/45) and corticosteroids (13/45). The mean number of antimicrobials was significantly higher in moderate-severe patients than mild cases (1.80 vs 1.12, p=0.001). Low number of deaths with a high recovery rate was reported. Diabetes was the most common comorbid condition followed by hypertension. Many antimicrobials were prescribed in both mild and moderate-severe cases that require careful review.
| Medienart: |
Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:34 |
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| Enthalten in: |
Pakistan journal of pharmaceutical sciences - 34(2021), 3(Supplementary) vom: 18. Mai, Seite 1135-1142 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kamran, Sairah Hafeez [VerfasserIn] |
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| Themen: |
Antiviral Agents |
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| Anmerkungen: |
Date Completed 13.10.2021 Date Revised 07.12.2022 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM331437430 |
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| 100 | 1 | |a Kamran, Sairah Hafeez |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a SARS-CoV-2 infection pattern, transmission and treatment |b Multi-center study in low to middle-income districts hospitals in Punjab, Pakistan |
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| 500 | |a Date Completed 13.10.2021 | ||
| 500 | |a Date Revised 07.12.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Pakistan has reported a substantial number of COVID-19 cases since 2020. A multicenter observational study was conducted to identify the pattern of SARS-CoV-2 infection, transmission, and treatment in patients admitted to seven low to middle-income district hospitals in the Province of Punjab, Pakistan from March to June 2020. A total of 102 patients were recruited. 57 patients tested positive and 45 developed moderate-severe COVID-19 disease. About 67% of the patients in March-April and 93% in May-June have contracted the disease from the local transmission. The mean number of symptoms in SARS-CoV-2 positive patients was significantly higher than suspected patients (6.46 vs 5.04, p=0.003). The number of deaths was low (n=8) with 86% recovery rate. Mild COVID patients received acetaminophen (n=102), azithromycin (n=8), and hydroxychloroquine (n=4) in addition to standard medical care. The treatment provided to moderate-severe cases included acetaminophen (45/45), azithromycin (45/45), Ivermectin (14/45) and corticosteroids (13/45). The mean number of antimicrobials was significantly higher in moderate-severe patients than mild cases (1.80 vs 1.12, p=0.001). Low number of deaths with a high recovery rate was reported. Diabetes was the most common comorbid condition followed by hypertension. Many antimicrobials were prescribed in both mild and moderate-severe cases that require careful review | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Observational Study | |
| 650 | 7 | |a Antiviral Agents |2 NLM | |
| 700 | 1 | |a Mustafa, Zia Ul |e verfasserin |4 aut | |
| 700 | 1 | |a Rao, Alina Zeeshan |e verfasserin |4 aut | |
| 700 | 1 | |a Hasan, Syed Shahzad |e verfasserin |4 aut | |
| 700 | 1 | |a Zahoor, Farheen |e verfasserin |4 aut | |
| 700 | 1 | |a Sarwar, Mohammad Umair |e verfasserin |4 aut | |
| 700 | 1 | |a Khan, Shehroze |e verfasserin |4 aut | |
| 700 | 1 | |a Butt, Sannan |e verfasserin |4 aut | |
| 700 | 1 | |a Rameez, Muhammad |e verfasserin |4 aut | |
| 700 | 1 | |a Asif Abbas, Muhammad |e verfasserin |4 aut | |
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