The nose can be the focus of treatment and prophylactic approaches against COVID-19
Infection with SARS-CoV-2 frequently commences in the nasal cavity, yet knowledge about this initial virus-host interaction is sparse. In this review, we update our current understanding of SARS-CoV-2 infection via the nasal epithelium and the associated local immune response. Furthermore, we present considerations to how this interaction may influence the clinical course of COVID-19 and the systemic immune response, and lastly touch upon the potential for intranasal vaccination, intranasal antiviral therapies and immunomodulatory approaches.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:183 |
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| Enthalten in: |
Ugeskrift for laeger - 183(2021), 37 vom: 13. Sept. |
| Sprache: |
Dänisch |
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| Beteiligte Personen: |
Rusan, Maria [VerfasserIn] |
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| Themen: |
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| Anmerkungen: |
Date Completed 08.10.2021 Date Revised 08.10.2021 published: Print Citation Status MEDLINE |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Infection with SARS-CoV-2 frequently commences in the nasal cavity, yet knowledge about this initial virus-host interaction is sparse. In this review, we update our current understanding of SARS-CoV-2 infection via the nasal epithelium and the associated local immune response. Furthermore, we present considerations to how this interaction may influence the clinical course of COVID-19 and the systemic immune response, and lastly touch upon the potential for intranasal vaccination, intranasal antiviral therapies and immunomodulatory approaches | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 700 | 1 | |a Ovesen, Thomas Oliver Kamarauskas |e verfasserin |4 aut | |
| 700 | 1 | |a Fuursted, Kurt |e verfasserin |4 aut | |
| 700 | 1 | |a Ovesen, Therese |e verfasserin |4 aut | |
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