Clinical impact of perioperative atrial fibrillation on long-term recurrence of malignancy
© 2021. Springer Japan KK, part of Springer Nature..
Perioperative complications have been reported to be associated with a lower incidence of cancer-free survival. Perioperative atrial fibrillation (POAF) is one of occasionally observed complications in patients with malignancies who undergo noncardiac surgeries. However, the long-term clinical impact of POAF on those with malignancies have remained unknown. This was a prospective, single-center, observational study. Patients who underwent noncardiac surgeries for definitive malignancies between 2014 and 2017 were included. The primary and secondary endpoints were 3-year recurrence of malignancies and cancer death, respectively. The present study included consecutive 752 patients (mean age, 68 ± 11 years; males, 62%), and POAF was observed in 77 patients. The follow-up duration was 1037 (interquartile range, 699-1408) days. The 3-year recurrence of malignancies was observed in 239 (32%) patients (POAF, 32 [42%]; non-POAF, 207 [31%]) and 3-year mortality was 130 patients (17%). Cardiac, noncardiac, and cancer deaths were observed in 4 (0.5%), 126 (17%), and 111 (15%) patients, respectively. Multivariate Cox regression analysis demonstrated that POAF was associated with 3-year recurrence of malignancies (hazard ratio [HR], 1.70; 95% confidence interval [CI], 1.15-2.52). Landmark analysis demonstrated that POAF tended to be correlated with the incidence of 3-year cancer death (HR, 1.79; 95% CI, 0.96-3.31). In conclusion, POAF is associated with the subsequent recurrence of malignancies. The association of arrhythmia with cancer death may be revealed under longer follow-up durations.Clinical Trial Registration: https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000018270 . UMIN ID: UMIN000016146.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:37 |
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| Enthalten in: |
Heart and vessels - 37(2022), 4 vom: 30. Apr., Seite 619-627 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Higuchi, Satoshi [VerfasserIn] |
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| Links: |
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| Themen: |
Cancer recurrence |
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| Anmerkungen: |
Date Completed 06.04.2022 Date Revised 06.04.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s00380-021-01954-4 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM331326272 |
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| 245 | 1 | 0 | |a Clinical impact of perioperative atrial fibrillation on long-term recurrence of malignancy |
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| 520 | |a © 2021. Springer Japan KK, part of Springer Nature. | ||
| 520 | |a Perioperative complications have been reported to be associated with a lower incidence of cancer-free survival. Perioperative atrial fibrillation (POAF) is one of occasionally observed complications in patients with malignancies who undergo noncardiac surgeries. However, the long-term clinical impact of POAF on those with malignancies have remained unknown. This was a prospective, single-center, observational study. Patients who underwent noncardiac surgeries for definitive malignancies between 2014 and 2017 were included. The primary and secondary endpoints were 3-year recurrence of malignancies and cancer death, respectively. The present study included consecutive 752 patients (mean age, 68 ± 11 years; males, 62%), and POAF was observed in 77 patients. The follow-up duration was 1037 (interquartile range, 699-1408) days. The 3-year recurrence of malignancies was observed in 239 (32%) patients (POAF, 32 [42%]; non-POAF, 207 [31%]) and 3-year mortality was 130 patients (17%). Cardiac, noncardiac, and cancer deaths were observed in 4 (0.5%), 126 (17%), and 111 (15%) patients, respectively. Multivariate Cox regression analysis demonstrated that POAF was associated with 3-year recurrence of malignancies (hazard ratio [HR], 1.70; 95% confidence interval [CI], 1.15-2.52). Landmark analysis demonstrated that POAF tended to be correlated with the incidence of 3-year cancer death (HR, 1.79; 95% CI, 0.96-3.31). In conclusion, POAF is associated with the subsequent recurrence of malignancies. The association of arrhythmia with cancer death may be revealed under longer follow-up durations.Clinical Trial Registration: https://upload.umin.ac.jp/cgi-open-bin/ctr_e/ctr_view.cgi?recptno=R000018270 . UMIN ID: UMIN000016146 | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a Cancer recurrence | |
| 650 | 4 | |a Noncardiac surgery for malignancy | |
| 650 | 4 | |a Perioperative atrial fibrillation | |
| 650 | 4 | |a Postoperative atrial fibrillation | |
| 700 | 1 | |a Kabeya, Yusuke |e verfasserin |4 aut | |
| 700 | 1 | |a Matsushita, Kenichi |e verfasserin |4 aut | |
| 700 | 1 | |a Tachibana, Keisei |e verfasserin |4 aut | |
| 700 | 1 | |a Kawachi, Riken |e verfasserin |4 aut | |
| 700 | 1 | |a Takei, Hidefumi |e verfasserin |4 aut | |
| 700 | 1 | |a Tanaka, Ryota |e verfasserin |4 aut | |
| 700 | 1 | |a Suzuki, Yutaka |e verfasserin |4 aut | |
| 700 | 1 | |a Imanishi, Yorihisa |e verfasserin |4 aut | |
| 700 | 1 | |a Shibata, Shigeki |e verfasserin |4 aut | |
| 700 | 1 | |a Hasegawa, Hiroshi |e verfasserin |4 aut | |
| 700 | 1 | |a Saito, Koichiro |e verfasserin |4 aut | |
| 700 | 1 | |a Moriyama, Kiyoshi |e verfasserin |4 aut | |
| 700 | 1 | |a Yorozu, Tomoko |e verfasserin |4 aut | |
| 700 | 1 | |a Abe, Nobutsugu |e verfasserin |4 aut | |
| 700 | 1 | |a Kondo, Haruhiko |e verfasserin |4 aut | |
| 700 | 1 | |a Matsuda, Takeaki |e verfasserin |4 aut | |
| 700 | 1 | |a Yoshino, Hideaki |e verfasserin |4 aut | |
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