Effects of Aerobic Exercise on Systemic Insulin Degludec Concentrations in People with Type 1 Diabetes
BACKGROUND: There is conflicting evidence on the effect of exercise on systemic insulin concentrations in adults with type 1 diabetes.
METHODS: This prospective single-arm study examined the effect of exercise on systemic insulin degludec (IDeg) concentrations. The study involved 15 male adults with type 1 diabetes (age 30.7 ± 8.0 years, HbA1c 6.9 ± 0.7%) on stable IDeg regimen. Blood samples were collected every 15 minutes at rest, during 60 minutes of cycling (66% VO2max) and until 90 minutes after exercise termination. IDeg concentrations were quantified using high-resolution mass-spectrometry and analyzed applying generalized estimation equations.
RESULTS: Compared to baseline, systemic IDeg increased during exercise over time (P < .001), with the highest concentrations observed toward the end of the 60-minute exercise (17.9% and 17.6% above baseline after 45 minutes and 60 minutes, respectively). IDeg levels remained elevated until the end of the experiment (14% above baseline at 90 minutes after exercise termination, P < .001).
CONCLUSIONS: A single bout of aerobic exercise increases systemic IDeg exposure in adults on a stable basal IDeg regimen. This finding may have important implications for future hypoglycemia mitigation strategies around physical exercise in IDeg-treated patients.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2023 |
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| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:17 |
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| Enthalten in: |
Journal of diabetes science and technology - 17(2023), 1 vom: 01. Jan., Seite 172-175 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Herzig, David [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 03.01.2023 Date Revised 22.02.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1177/19322968211043915 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: There is conflicting evidence on the effect of exercise on systemic insulin concentrations in adults with type 1 diabetes | ||
| 520 | |a METHODS: This prospective single-arm study examined the effect of exercise on systemic insulin degludec (IDeg) concentrations. The study involved 15 male adults with type 1 diabetes (age 30.7 ± 8.0 years, HbA1c 6.9 ± 0.7%) on stable IDeg regimen. Blood samples were collected every 15 minutes at rest, during 60 minutes of cycling (66% VO2max) and until 90 minutes after exercise termination. IDeg concentrations were quantified using high-resolution mass-spectrometry and analyzed applying generalized estimation equations | ||
| 520 | |a RESULTS: Compared to baseline, systemic IDeg increased during exercise over time (P < .001), with the highest concentrations observed toward the end of the 60-minute exercise (17.9% and 17.6% above baseline after 45 minutes and 60 minutes, respectively). IDeg levels remained elevated until the end of the experiment (14% above baseline at 90 minutes after exercise termination, P < .001) | ||
| 520 | |a CONCLUSIONS: A single bout of aerobic exercise increases systemic IDeg exposure in adults on a stable basal IDeg regimen. This finding may have important implications for future hypoglycemia mitigation strategies around physical exercise in IDeg-treated patients | ||
| 650 | 4 | |a Journal Article | |
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| 700 | 1 | |a Groessl, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Álvarez-Martínez, Mario |e verfasserin |4 aut | |
| 700 | 1 | |a Reverter-Branchat, Gemma |e verfasserin |4 aut | |
| 700 | 1 | |a Nakas, Christos T |e verfasserin |4 aut | |
| 700 | 1 | |a Kosinski, Christophe |e verfasserin |4 aut | |
| 700 | 1 | |a Stettler, Christoph |e verfasserin |4 aut | |
| 700 | 1 | |a Bally, Lia |e verfasserin |4 aut | |
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