An optimal multiarmed response adaptive design for survival outcome with independent censoring
© 2021 Wiley-VCH GmbH..
Compromising ethics and precision in the context of a multiarmed clinical trial, an optimal order adjusted response adaptive design is proposed for survival outcomes subject to independent random censoring. The operating characteristics of the proposed design and the follow-up inference are studied both theoretically as well as empirically and are compared with those of the competitors. Applicability of the developed design is further illustrated through redesigning a real clinical trial with survival responses.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:64 |
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| Enthalten in: |
Biometrical journal. Biometrische Zeitschrift - 64(2022), 1 vom: 29. Jan., Seite 165-185 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Das, Soumyadeep [VerfasserIn] |
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| Links: |
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| Themen: |
Independent censoring |
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| Anmerkungen: |
Date Completed 25.04.2022 Date Revised 25.04.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1002/bimj.202000089 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM331272873 |
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| 520 | |a Compromising ethics and precision in the context of a multiarmed clinical trial, an optimal order adjusted response adaptive design is proposed for survival outcomes subject to independent random censoring. The operating characteristics of the proposed design and the follow-up inference are studied both theoretically as well as empirically and are compared with those of the competitors. Applicability of the developed design is further illustrated through redesigning a real clinical trial with survival responses | ||
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