Significance of Hereditary Hemochromatosis Gene (HFE) Mutations in Chronic Hepatitis C and Hepatocellular Carcinoma Patients in Egypt : A Pilot Study
BACKGROUND: Hereditary hemochromatosis is a genetic disease defined by enhanced overloading of iron and associated with Chronic Hepatitis C (CHC). This study aims to evaluate the correlation of the HFE gene mutations on Egyptian CHC with liver disease progression and the risk of HCC development.
METHODS: The HFE mutations (C282Y and H63D) were genotyped on 100 CHC patients and 50 healthy individuals by a hybridization assay. The serum iron content was also measured for all subjects.
RESULTS: A significant elevation of the serum iron, ferritin, and TIBC in HCV-infected patients (p≤0.05). The H63D mutation was detected in 23% of the all studied samples. The serum iron and the H63D heterozygosity were correlated significantly between non-cirrhotic and cirrhotic without HCC patients.
CONCLUSION: The H63D heterozygosity might have a potential role in iron accumulation. Moreover, HFE mutations did not tend to be associated with an increased risk of HCC in cirrhotic patients.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:22 |
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| Enthalten in: |
Asian Pacific journal of cancer prevention : APJCP - 22(2021), 9 vom: 01. Sept., Seite 2837-2845 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Dawood, Reham M [VerfasserIn] |
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| Links: |
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| Themen: |
HFE gene polymorphism |
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| Anmerkungen: |
Date Completed 22.12.2021 Date Revised 25.02.2022 published: Electronic Citation Status MEDLINE |
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| doi: |
10.31557/APJCP.2021.22.9.2837 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM33124201X |
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| 100 | 1 | |a Dawood, Reham M |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Significance of Hereditary Hemochromatosis Gene (HFE) Mutations in Chronic Hepatitis C and Hepatocellular Carcinoma Patients in Egypt |b A Pilot Study |
| 264 | 1 | |c 2021 | |
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| 500 | |a Date Completed 22.12.2021 | ||
| 500 | |a Date Revised 25.02.2022 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Hereditary hemochromatosis is a genetic disease defined by enhanced overloading of iron and associated with Chronic Hepatitis C (CHC). This study aims to evaluate the correlation of the HFE gene mutations on Egyptian CHC with liver disease progression and the risk of HCC development | ||
| 520 | |a METHODS: The HFE mutations (C282Y and H63D) were genotyped on 100 CHC patients and 50 healthy individuals by a hybridization assay. The serum iron content was also measured for all subjects | ||
| 520 | |a RESULTS: A significant elevation of the serum iron, ferritin, and TIBC in HCV-infected patients (p≤0.05). The H63D mutation was detected in 23% of the all studied samples. The serum iron and the H63D heterozygosity were correlated significantly between non-cirrhotic and cirrhotic without HCC patients | ||
| 520 | |a CONCLUSION: The H63D heterozygosity might have a potential role in iron accumulation. Moreover, HFE mutations did not tend to be associated with an increased risk of HCC in cirrhotic patients | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a HFE gene polymorphism | |
| 650 | 4 | |a Hemochromatosis | |
| 650 | 4 | |a Hepatitis C | |
| 650 | 4 | |a Iron | |
| 700 | 1 | |a Abd El Meguid, Mai |e verfasserin |4 aut | |
| 700 | 1 | |a Elrobe, Walied |e verfasserin |4 aut | |
| 700 | 1 | |a Salum, Ghada M |e verfasserin |4 aut | |
| 700 | 1 | |a Zayed, Naglaa |e verfasserin |4 aut | |
| 700 | 1 | |a Mousa, Sherief |e verfasserin |4 aut | |
| 700 | 1 | |a Medhat, Eman |e verfasserin |4 aut | |
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