Multiple myeloma : therapeutic delivery of antibodies and aptamers
Multiple myeloma is the second most common hematological malignancy in adults, accounting for 2% of all cancer-related deaths in the UK. Current chemotherapy-based regimes are insufficient, as most patients relapse and develop therapy resistance. This review focuses on current novel antibody- and aptamer-based therapies aiming to overcome current therapy limitations, as well as their respective limitations and areas of improvement. The use of computer modeling methods, as a tool to study and improve ligand-receptor alignments for the use of novel therapy development will also be discussed, as it has become a rapid, reliable and comparatively inexpensive method of investigation.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
|---|---|
| Enthalten in: |
Therapeutic delivery - 12(2021), 10 vom: 01. Okt., Seite 705-722 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Pujol-Navarro, Neret [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Antibody–drug conjugates |
|---|
| Anmerkungen: |
Date Completed 20.12.2021 Date Revised 20.12.2021 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.4155/tde-2021-0041 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM331109093 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM331109093 | ||
| 003 | DE-627 | ||
| 005 | 20231225212734.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.4155/tde-2021-0041 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1103.xml |
| 035 | |a (DE-627)NLM331109093 | ||
| 035 | |a (NLM)34569269 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Pujol-Navarro, Neret |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Multiple myeloma |b therapeutic delivery of antibodies and aptamers |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 20.12.2021 | ||
| 500 | |a Date Revised 20.12.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Multiple myeloma is the second most common hematological malignancy in adults, accounting for 2% of all cancer-related deaths in the UK. Current chemotherapy-based regimes are insufficient, as most patients relapse and develop therapy resistance. This review focuses on current novel antibody- and aptamer-based therapies aiming to overcome current therapy limitations, as well as their respective limitations and areas of improvement. The use of computer modeling methods, as a tool to study and improve ligand-receptor alignments for the use of novel therapy development will also be discussed, as it has become a rapid, reliable and comparatively inexpensive method of investigation | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a antibody therapy | |
| 650 | 4 | |a antibody–drug conjugates | |
| 650 | 4 | |a aptamer therapy | |
| 650 | 4 | |a aptamer–drug conjugates | |
| 650 | 4 | |a molecular docking | |
| 650 | 4 | |a multiple myeloma | |
| 650 | 4 | |a nanoparticles | |
| 700 | 1 | |a Al Qaraghuli, Mohammed M |e verfasserin |4 aut | |
| 700 | 1 | |a Kubiak-Ossowska, Karina |e verfasserin |4 aut | |
| 700 | 1 | |a Alsaadi, Manal M |e verfasserin |4 aut | |
| 700 | 1 | |a Horne, Gillian A |e verfasserin |4 aut | |
| 700 | 1 | |a Soutar, Richard L |e verfasserin |4 aut | |
| 700 | 1 | |a Paspali, Elpiniki |e verfasserin |4 aut | |
| 700 | 1 | |a Ferro, Valerie A |e verfasserin |4 aut | |
| 700 | 1 | |a Williams, Mark Ts |e verfasserin |4 aut | |
| 700 | 1 | |a Mulheran, Paul A |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Therapeutic delivery |d 2010 |g 12(2021), 10 vom: 01. Okt., Seite 705-722 |w (DE-627)NLM203937082 |x 2041-6008 |7 nnns |
| 773 | 1 | 8 | |g volume:12 |g year:2021 |g number:10 |g day:01 |g month:10 |g pages:705-722 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.4155/tde-2021-0041 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 12 |j 2021 |e 10 |b 01 |c 10 |h 705-722 | ||