Potential beneficial effects of bariatric surgery on the prevalence of kidney cancer : a national database study
Copyright © 2021 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved..
BACKGROUND: The incidence of obesity has been steadily increasing, especially in developed countries. Also, obesity is considered one of the modifiable risk factors of kidney cancer.
OBJECTIVES: This study aims to determine the impact of bariatric surgery-induced weight loss on the prevention of kidney cancer.
SETTING: Academic Hospital, United States.
METHODS: The National (Nationwide) Inpatient Sample (NIS) was queried for the period 2010 to 2015 for first-time kidney cancer-related hospitalization, used as a proxy for cancer incidence, in patients with a history of bariatric surgery (cases) and patients with obesity but no history of bariatric surgery (controls). Patients with a previous diagnosis of cancer were excluded from the analysis. In order to identify comparable patients, all controls had to have a body mass index ≥35 kg/m2, as per the existing qualification criteria for bariatric surgery. The International Classification of Diseases-9 codes (ICD-9) was used to identify admissions for kidney cancer. A univariate analysis was conducted to compare demographics and co-morbidities between groups. A multivariate logistic regression model was performed to assess differences between surgical and control groups and adjust for independent variables such as smoking history and family history of malignancy. All percentages and means (with confidence intervals [CIs]) were weighted.
RESULTS: A total of 2,300,845 were included in the analysis, of which 2,004,804 controls-subjects, with a mean age of 54.4 ± .05 years, and 296,041 treatment-subjects, with a mean age of 51.9 ± .05 years. Demographics and co-morbidities, such as tobacco use, diabetes, and hypertension, were also measured. Patients with a history of bariatric surgery were significantly less likely to experience renal cancer than patients without a history of bariatric surgery, with 5935 cases in the control group and 684 in the case group (P < .0001). After a multivariate logistic regression was performed, the OR was 1.10 (95% CI: 1.02-1.22, P < .0224).
CONCLUSION: Our finding suggests that bariatric surgery-induced weight loss could significantly prevent first-time kidney cancer-related hospitalizations in patients with obesity. Prospective studies are needed to confirm our findings.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:18 |
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| Enthalten in: |
Surgery for obesity and related diseases : official journal of the American Society for Bariatric Surgery - 18(2022), 1 vom: 28. Jan., Seite 102-106 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Botero-Fonnegra, Cristina [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 28.03.2022 Date Revised 01.04.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.soard.2021.08.012 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM331073358 |
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| 245 | 1 | 0 | |a Potential beneficial effects of bariatric surgery on the prevalence of kidney cancer |b a national database study |
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| 500 | |a Date Revised 01.04.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2021 American Society for Bariatric Surgery. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a BACKGROUND: The incidence of obesity has been steadily increasing, especially in developed countries. Also, obesity is considered one of the modifiable risk factors of kidney cancer | ||
| 520 | |a OBJECTIVES: This study aims to determine the impact of bariatric surgery-induced weight loss on the prevention of kidney cancer | ||
| 520 | |a SETTING: Academic Hospital, United States | ||
| 520 | |a METHODS: The National (Nationwide) Inpatient Sample (NIS) was queried for the period 2010 to 2015 for first-time kidney cancer-related hospitalization, used as a proxy for cancer incidence, in patients with a history of bariatric surgery (cases) and patients with obesity but no history of bariatric surgery (controls). Patients with a previous diagnosis of cancer were excluded from the analysis. In order to identify comparable patients, all controls had to have a body mass index ≥35 kg/m2, as per the existing qualification criteria for bariatric surgery. The International Classification of Diseases-9 codes (ICD-9) was used to identify admissions for kidney cancer. A univariate analysis was conducted to compare demographics and co-morbidities between groups. A multivariate logistic regression model was performed to assess differences between surgical and control groups and adjust for independent variables such as smoking history and family history of malignancy. All percentages and means (with confidence intervals [CIs]) were weighted | ||
| 520 | |a RESULTS: A total of 2,300,845 were included in the analysis, of which 2,004,804 controls-subjects, with a mean age of 54.4 ± .05 years, and 296,041 treatment-subjects, with a mean age of 51.9 ± .05 years. Demographics and co-morbidities, such as tobacco use, diabetes, and hypertension, were also measured. Patients with a history of bariatric surgery were significantly less likely to experience renal cancer than patients without a history of bariatric surgery, with 5935 cases in the control group and 684 in the case group (P < .0001). After a multivariate logistic regression was performed, the OR was 1.10 (95% CI: 1.02-1.22, P < .0224) | ||
| 520 | |a CONCLUSION: Our finding suggests that bariatric surgery-induced weight loss could significantly prevent first-time kidney cancer-related hospitalizations in patients with obesity. Prospective studies are needed to confirm our findings | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Bariatric surgery | |
| 650 | 4 | |a Kidney cancer | |
| 650 | 4 | |a Renal cancer | |
| 700 | 1 | |a Funes, David Romero |e verfasserin |4 aut | |
| 700 | 1 | |a Valera, Roberto J |e verfasserin |4 aut | |
| 700 | 1 | |a Gómez, Camila Ortiz |e verfasserin |4 aut | |
| 700 | 1 | |a Lo Menzo, Emanuele |e verfasserin |4 aut | |
| 700 | 1 | |a Szomstein, Samuel |e verfasserin |4 aut | |
| 700 | 1 | |a Rosenthal, Raul J |e verfasserin |4 aut | |
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| 773 | 1 | 8 | |g volume:18 |g year:2022 |g number:1 |g day:28 |g month:01 |g pages:102-106 |
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