Cross-reactive Antibody Response to mRNA SARS-CoV-2 Vaccine After Recent COVID-19-Specific Monoclonal Antibody Therapy

© The Author(s) 2021. Published by Oxford University Press on behalf of Infectious Diseases Society of America..

The efficacy of coronavirus disease 2019 (COVID-19) vaccines administered after COVID-19-specific monoclonal antibody is unknown, and "antibody interference" might hinder immune responses leading to vaccine failure. In an institutional review board-approved prospective study, we found that an individual who received mRNA COVID-19 vaccination <40 days after COVID-19-specific monoclonal antibody therapy for symptomatic COVID-19 had similar postvaccine antibody responses to SARS-CoV-2 receptor binding domain (RBD) for 4 important SARS-CoV-2 variants (B.1, B.1.1.7, B.1.351, and P.1) as other participants who were also vaccinated following COVID-19. Vaccination against COVID-19 shortly after COVID-19-specific monoclonal antibody can boost and expand antibody protection, questioning the need to delay vaccination in this setting.

TRIAL REGISTRATION: The St. Jude Tracking of Viral and Host Factors Associated with COVID-19 study; NCT04362995; https://clinicaltrials.gov/ct2/show/NCT04362995.

Medienart:

E-Artikel

Erscheinungsjahr:

2021

Erschienen:

2021

Enthalten in:

Zur Gesamtaufnahme - volume:8

Enthalten in:

Open forum infectious diseases - 8(2021), 9 vom: 17. Sept., Seite ofab420

Sprache:

Englisch

Beteiligte Personen:

Schultz-Cherry, Stacey [VerfasserIn]
McGargill, Maureen A [VerfasserIn]
Thomas, Paul G [VerfasserIn]
Estepp, Jeremie H [VerfasserIn]
Gaur, Aditya H [VerfasserIn]
Allen, E Kaitlynn [VerfasserIn]
Allison, Kim J [VerfasserIn]
Tang, Li [VerfasserIn]
Webby, Richard J [VerfasserIn]
Cherry, Sean D [VerfasserIn]
Lin, Chun-Yang [VerfasserIn]
Fabrizio, Thomas [VerfasserIn]
Tuomanen, Elaine I [VerfasserIn]
Wolf, Joshua [VerfasserIn]
SJTRC Investigative Team [VerfasserIn]
Kirkpatrick Roubidoux, Ericka [Sonstige Person]
Freiden, Pamela [Sonstige Person]
Mori, Tomi [Sonstige Person]
Hijano, Diego R [Sonstige Person]
Hakim, Hana [Sonstige Person]
Brice, David C [Sonstige Person]
Castellaw, Ashley [Sonstige Person]
Krammer, Florian [Sonstige Person]
Wittman, David E [Sonstige Person]
Hodges, Jason [Sonstige Person]
Dallas, Ronald H [Sonstige Person]
Cortez, Valerie [Sonstige Person]
Vazquez-Pagan, Ana [Sonstige Person]
Bajracharya, Resha [Sonstige Person]
Clark, Brandi L [Sonstige Person]
Van de Velde, Lee-Ann [Sonstige Person]
Awad, Walid [Sonstige Person]
Wilson, Taylor L [Sonstige Person]
Kirk, Allison M [Sonstige Person]
Hayden, Randall T [Sonstige Person]
Hoffman, James [Sonstige Person]
Russell-Bell, Jamie [Sonstige Person]
Sparks, James [Sonstige Person]

Links:

Volltext

Themen:

Antibody
Bamlanivimab
COVID-19
Journal Article
SARS-CoV-2
Vaccine failure

Anmerkungen:

Date Revised 26.04.2022

published: Electronic-eCollection

ClinicalTrials.gov: NCT04362995

Citation Status PubMed-not-MEDLINE

doi:

10.1093/ofid/ofab420

funding:

Förderinstitution / Projekttitel:

PPN (Katalog-ID):

NLM33099252X