A comparative study of porcine antihuman lymphocyte globulin versus antithymocyte globulin-fresenius in an allogeneic hematopoietic cell transplantation conditioning regimen for severe aplastic anemia
OBJECTIVES: To compare the outcomes of antihuman T lymphocyte globulin (ATG-F) and porcine antihuman lymphocyte globulin (p-ALG) as part of a conditioning regimen in hematopoietic stem cell transplantation (HSCT) for severe aplastic anemia (SAA).
METHODS: we performed a retrospective analysis, evaluating the outcome of patients with SAA who received ATG-F based conditioning (n = 26) with those receiving p-ALG conditioning (n = 34).
RESULTS: The median time to neutrophil engraftment was 11 days (range, 8 - 38) and 11 days (range, 9 - 24) in the p-ALG and ATG-F groups (P = 0.857); the median platelet engraftment time was 15 (range, 9 - 330) days and 13 (range, 10 - 56) days (P = 0.155). There were no significant differences in grades II - IV acute graft-versus-host disease (aGVHD), grades III - IV aGVHD, chronic GVHD (cGVHD), and the moderate-severe cGVHD between the ATG-F and p-ALG groups (P>0.05).
DISCUSSION: Patients in the ATG-F group functioned significantly better on role-physical (P = 0.006), general health (P = 0.029), and physical component summary (P = 0.009). The estimated overall survival and failure free survival rates at 5 years were 88.5% ± 6.3% vs. 82.4% ± 6.5% (P = 0.515), 84.6% ± 7.1% vs. 79.4% ± 6.9%, respectively (P = 0.579). The infection rates were 61.53% and 47.05%, respectively (P = 0.265).
CONCLUSION: As part of the conditioning regimen, p-ALG achieved a similar efficacy as ATG-F without increasing the incidence of transplantation complications in SAA patients.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:26 |
|---|---|
| Enthalten in: |
Hematology (Amsterdam, Netherlands) - 26(2021), 1 vom: 27. Dez., Seite 741-750 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Zhang, Yanming [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Antilymphocyte Serum |
|---|
| Anmerkungen: |
Date Completed 28.10.2021 Date Revised 26.04.2022 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.1080/16078454.2021.1974201 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM330970208 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM330970208 | ||
| 003 | DE-627 | ||
| 005 | 20231225212435.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1080/16078454.2021.1974201 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1103.xml |
| 035 | |a (DE-627)NLM330970208 | ||
| 035 | |a (NLM)34555301 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Zhang, Yanming |e verfasserin |4 aut | |
| 245 | 1 | 2 | |a A comparative study of porcine antihuman lymphocyte globulin versus antithymocyte globulin-fresenius in an allogeneic hematopoietic cell transplantation conditioning regimen for severe aplastic anemia |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 28.10.2021 | ||
| 500 | |a Date Revised 26.04.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVES: To compare the outcomes of antihuman T lymphocyte globulin (ATG-F) and porcine antihuman lymphocyte globulin (p-ALG) as part of a conditioning regimen in hematopoietic stem cell transplantation (HSCT) for severe aplastic anemia (SAA) | ||
| 520 | |a METHODS: we performed a retrospective analysis, evaluating the outcome of patients with SAA who received ATG-F based conditioning (n = 26) with those receiving p-ALG conditioning (n = 34) | ||
| 520 | |a RESULTS: The median time to neutrophil engraftment was 11 days (range, 8 - 38) and 11 days (range, 9 - 24) in the p-ALG and ATG-F groups (P = 0.857); the median platelet engraftment time was 15 (range, 9 - 330) days and 13 (range, 10 - 56) days (P = 0.155). There were no significant differences in grades II - IV acute graft-versus-host disease (aGVHD), grades III - IV aGVHD, chronic GVHD (cGVHD), and the moderate-severe cGVHD between the ATG-F and p-ALG groups (P>0.05) | ||
| 520 | |a DISCUSSION: Patients in the ATG-F group functioned significantly better on role-physical (P = 0.006), general health (P = 0.029), and physical component summary (P = 0.009). The estimated overall survival and failure free survival rates at 5 years were 88.5% ± 6.3% vs. 82.4% ± 6.5% (P = 0.515), 84.6% ± 7.1% vs. 79.4% ± 6.9%, respectively (P = 0.579). The infection rates were 61.53% and 47.05%, respectively (P = 0.265) | ||
| 520 | |a CONCLUSION: As part of the conditioning regimen, p-ALG achieved a similar efficacy as ATG-F without increasing the incidence of transplantation complications in SAA patients | ||
| 650 | 4 | |a Comparative Study | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Severe aplastic anemia | |
| 650 | 4 | |a antithymocyte globulin | |
| 650 | 4 | |a hematopoietic stem cell transplantation | |
| 650 | 4 | |a porcine antihuman lymphocyte globulin | |
| 650 | 7 | |a Antilymphocyte Serum |2 NLM | |
| 700 | 1 | |a Liu, Limin |e verfasserin |4 aut | |
| 700 | 1 | |a Si, Yejun |e verfasserin |4 aut | |
| 700 | 1 | |a Miao, Miao |e verfasserin |4 aut | |
| 700 | 1 | |a Qiu, Huiying |e verfasserin |4 aut | |
| 700 | 1 | |a Tang, Xiaowen |e verfasserin |4 aut | |
| 700 | 1 | |a Han, Yue |e verfasserin |4 aut | |
| 700 | 1 | |a Fu, Chengcheng |e verfasserin |4 aut | |
| 700 | 1 | |a Jin, Zhengming |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Suning |e verfasserin |4 aut | |
| 700 | 1 | |a Sun, Aining |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Depei |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Hematology (Amsterdam, Netherlands) |d 1996 |g 26(2021), 1 vom: 27. Dez., Seite 741-750 |w (DE-627)NLM096477237 |x 1607-8454 |7 nnns |
| 773 | 1 | 8 | |g volume:26 |g year:2021 |g number:1 |g day:27 |g month:12 |g pages:741-750 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1080/16078454.2021.1974201 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 26 |j 2021 |e 1 |b 27 |c 12 |h 741-750 | ||