Survival in influenza virus-related pneumonia by viral subtype : 2016-2020
Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved..
BACKGROUND: Influenza remains a common cause of morbidity and mortality worldwide, and viral subtype-related differences in disease outcomes have been documented.
OBJECTIVE: To characterize the survival experience of adult inpatients with influenza virus-associated pneumonia by viral subtype during five consecutive flu seasons.
METHOD: We performed a retrospective cohort study; data from 4,678 adults were analyzed using the Kaplan-Meier method. A multivariate Cox proportional hazard regression model was fitted.
RESULTS: The overall in-hospital mortality rate was 25.0 per 1,000 hospital days. The survival probabilities from pneumonia patients went from 93.4% (95% CI 92.6-94.1%) by day three to 43.3% (95% CI 39.2-47.4%) by day 30 from hospital admission. In general, the lowest survival rates were observed in patients with AH1N1 infection. In multiple models, after adjusting for comorbidities and when compared with A non-subtyped virus, pneumonia patients with AH3N2 or B strains had a significantly decreased risk of a non-favorable disease outcome. The association of other strains was not significant.
CONCLUSIONS: Our findings suggest that the survival of inpatients with influenza virus-associated pneumonia varies according to the pathogenic viral subtype; the lowest survival rates were observed in patients with AH1N1 infection. This effect was independent of the patients' gender, age, and the analyzed underlying health conditions.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:112 |
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| Enthalten in: |
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 112(2021) vom: 02. Nov., Seite 288-293 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Murillo-Zamora, Efrén [VerfasserIn] |
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| Links: |
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| Themen: |
Influenza, Human |
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| Anmerkungen: |
Date Completed 03.12.2021 Date Revised 14.12.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.ijid.2021.09.037 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM330893076 |
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| 500 | |a Date Revised 14.12.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved. | ||
| 520 | |a BACKGROUND: Influenza remains a common cause of morbidity and mortality worldwide, and viral subtype-related differences in disease outcomes have been documented | ||
| 520 | |a OBJECTIVE: To characterize the survival experience of adult inpatients with influenza virus-associated pneumonia by viral subtype during five consecutive flu seasons | ||
| 520 | |a METHOD: We performed a retrospective cohort study; data from 4,678 adults were analyzed using the Kaplan-Meier method. A multivariate Cox proportional hazard regression model was fitted | ||
| 520 | |a RESULTS: The overall in-hospital mortality rate was 25.0 per 1,000 hospital days. The survival probabilities from pneumonia patients went from 93.4% (95% CI 92.6-94.1%) by day three to 43.3% (95% CI 39.2-47.4%) by day 30 from hospital admission. In general, the lowest survival rates were observed in patients with AH1N1 infection. In multiple models, after adjusting for comorbidities and when compared with A non-subtyped virus, pneumonia patients with AH3N2 or B strains had a significantly decreased risk of a non-favorable disease outcome. The association of other strains was not significant | ||
| 520 | |a CONCLUSIONS: Our findings suggest that the survival of inpatients with influenza virus-associated pneumonia varies according to the pathogenic viral subtype; the lowest survival rates were observed in patients with AH1N1 infection. This effect was independent of the patients' gender, age, and the analyzed underlying health conditions | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Influenza, Human | |
| 650 | 4 | |a Inpatients | |
| 650 | 4 | |a Pneumonia, Viral | |
| 650 | 4 | |a Proportional Hazards Models | |
| 650 | 4 | |a Survival Rate | |
| 700 | 1 | |a Trujillo, Xóchitl |e verfasserin |4 aut | |
| 700 | 1 | |a Huerta, Miguel |e verfasserin |4 aut | |
| 700 | 1 | |a Ríos-Silva, Mónica |e verfasserin |4 aut | |
| 700 | 1 | |a Guzmán-Esquivel, José |e verfasserin |4 aut | |
| 700 | 1 | |a Benites-Godínez, Verónica |e verfasserin |4 aut | |
| 700 | 1 | |a Mendoza-Cano, Oliver |e verfasserin |4 aut | |
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