Neurological Manifestations Associated with Parvovirus B19 Infection in Immunocompetent Children : Case Series and Systematic Review
Published by Oxford University Press 2021. This work is written by US Government employees and is in the public domain in the US..
An increasing number of reports have described human parvovirus B19 infection in association with a variety of neurological manifestations, especially in children. This study assessed the clinical and laboratory outcomes found in a case series of immunocompetent children who tested positive for parvovirus B19 by qualitative polymerase chain reaction assays of cerebrospinal fluid, in a tertiary referral center in the western Brazilian Amazon. We screened 178 children with clinically diagnosed central nervous system infections (meningoencephalitis). Of these, five (2.8%) were positive for parvovirus B19. A literature review also presented herein identified a further 50 cases of parvovirus B19 with neurological manifestations. Thus, even if the classic signs of parvovirus B19 infection are absent, such as the well-known rash, children with signs of neurological infection should also be evaluated for parvovirus B19 infection.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2021 |
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Erschienen: |
2021 |
Enthalten in: |
Zur Gesamtaufnahme - volume:67 |
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Enthalten in: |
Journal of tropical pediatrics - 67(2021), 4 vom: 27. Aug. |
Sprache: |
Englisch |
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Beteiligte Personen: |
Monteiro, Vinícius Silva [VerfasserIn] |
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Links: |
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Themen: |
Case series |
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Anmerkungen: |
Date Completed 02.11.2021 Date Revised 31.10.2023 published: Print Citation Status MEDLINE |
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doi: |
10.1093/tropej/fmab078 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM330872516 |
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520 | |a Published by Oxford University Press 2021. This work is written by US Government employees and is in the public domain in the US. | ||
520 | |a An increasing number of reports have described human parvovirus B19 infection in association with a variety of neurological manifestations, especially in children. This study assessed the clinical and laboratory outcomes found in a case series of immunocompetent children who tested positive for parvovirus B19 by qualitative polymerase chain reaction assays of cerebrospinal fluid, in a tertiary referral center in the western Brazilian Amazon. We screened 178 children with clinically diagnosed central nervous system infections (meningoencephalitis). Of these, five (2.8%) were positive for parvovirus B19. A literature review also presented herein identified a further 50 cases of parvovirus B19 with neurological manifestations. Thus, even if the classic signs of parvovirus B19 infection are absent, such as the well-known rash, children with signs of neurological infection should also be evaluated for parvovirus B19 infection | ||
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