A novel nairovirus associated with acute febrile illness in Hokkaido, Japan
© 2021. The Author(s)..
The increasing burden of tick-borne orthonairovirus infections, such as Crimean-Congo hemorrhagic fever, is becoming a global concern for public health. In the present study, we identify a novel orthonairovirus, designated Yezo virus (YEZV), from two patients showing acute febrile illness with thrombocytopenia and leukopenia after tick bite in Hokkaido, Japan, in 2019 and 2020, respectively. YEZV is phylogenetically grouped with Sulina virus detected in Ixodes ricinus ticks in Romania. YEZV infection has been confirmed in seven patients from 2014-2020, four of whom were co-infected with Borrelia spp. Antibodies to YEZV are found in wild deer and raccoons, and YEZV RNAs have been detected in ticks from Hokkaido. In this work, we demonstrate that YEZV is highly likely to be the causative pathogen of febrile illness, representing the first report of an endemic infection associated with an orthonairovirus potentially transmitted by ticks in Japan.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
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| Enthalten in: |
Nature communications - 12(2021), 1 vom: 20. Sept., Seite 5539 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kodama, Fumihiro [VerfasserIn] |
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| Links: |
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| Themen: |
Antibodies, Viral |
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| Anmerkungen: |
Date Completed 12.10.2021 Date Revised 16.02.2022 published: Electronic Citation Status MEDLINE |
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| doi: |
10.1038/s41467-021-25857-0 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM330869450 |
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| 100 | 1 | |a Kodama, Fumihiro |e verfasserin |4 aut | |
| 245 | 1 | 2 | |a A novel nairovirus associated with acute febrile illness in Hokkaido, Japan |
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| 500 | |a Date Revised 16.02.2022 | ||
| 500 | |a published: Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2021. The Author(s). | ||
| 520 | |a The increasing burden of tick-borne orthonairovirus infections, such as Crimean-Congo hemorrhagic fever, is becoming a global concern for public health. In the present study, we identify a novel orthonairovirus, designated Yezo virus (YEZV), from two patients showing acute febrile illness with thrombocytopenia and leukopenia after tick bite in Hokkaido, Japan, in 2019 and 2020, respectively. YEZV is phylogenetically grouped with Sulina virus detected in Ixodes ricinus ticks in Romania. YEZV infection has been confirmed in seven patients from 2014-2020, four of whom were co-infected with Borrelia spp. Antibodies to YEZV are found in wild deer and raccoons, and YEZV RNAs have been detected in ticks from Hokkaido. In this work, we demonstrate that YEZV is highly likely to be the causative pathogen of febrile illness, representing the first report of an endemic infection associated with an orthonairovirus potentially transmitted by ticks in Japan | ||
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| 700 | 1 | |a Park, Eunsil |e verfasserin |4 aut | |
| 700 | 1 | |a Tatemoto, Kango |e verfasserin |4 aut | |
| 700 | 1 | |a Sashika, Mariko |e verfasserin |4 aut | |
| 700 | 1 | |a Nakao, Ryo |e verfasserin |4 aut | |
| 700 | 1 | |a Terauchi, Yurino |e verfasserin |4 aut | |
| 700 | 1 | |a Mizuma, Keita |e verfasserin |4 aut | |
| 700 | 1 | |a Orba, Yasuko |e verfasserin |4 aut | |
| 700 | 1 | |a Kariwa, Hiroaki |e verfasserin |4 aut | |
| 700 | 1 | |a Hagiwara, Katsuro |e verfasserin |4 aut | |
| 700 | 1 | |a Okazaki, Katsunori |e verfasserin |4 aut | |
| 700 | 1 | |a Goto, Akiko |e verfasserin |4 aut | |
| 700 | 1 | |a Komagome, Rika |e verfasserin |4 aut | |
| 700 | 1 | |a Miyoshi, Masahiro |e verfasserin |4 aut | |
| 700 | 1 | |a Ito, Takuya |e verfasserin |4 aut | |
| 700 | 1 | |a Yamano, Kimiaki |e verfasserin |4 aut | |
| 700 | 1 | |a Yoshii, Kentaro |e verfasserin |4 aut | |
| 700 | 1 | |a Funaki, Chiaki |e verfasserin |4 aut | |
| 700 | 1 | |a Ishizuka, Mariko |e verfasserin |4 aut | |
| 700 | 1 | |a Shigeno, Asako |e verfasserin |4 aut | |
| 700 | 1 | |a Itakura, Yukari |e verfasserin |4 aut | |
| 700 | 1 | |a Bell-Sakyi, Lesley |e verfasserin |4 aut | |
| 700 | 1 | |a Edagawa, Shunji |e verfasserin |4 aut | |
| 700 | 1 | |a Nagasaka, Atsushi |e verfasserin |4 aut | |
| 700 | 1 | |a Sakoda, Yoshihiro |e verfasserin |4 aut | |
| 700 | 1 | |a Sawa, Hirofumi |e verfasserin |4 aut | |
| 700 | 1 | |a Maeda, Ken |e verfasserin |4 aut | |
| 700 | 1 | |a Saijo, Masayuki |e verfasserin |4 aut | |
| 700 | 1 | |a Matsuno, Keita |e verfasserin |4 aut | |
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