Development and evaluation of phytosome-loaded microsphere system for delivery of ginseng extract
The current research work focuses mainly on evolving a delivery system for ginseng extract (GE), which in turn will ameliorate the neuroprotective potential through enhancing the Ginsenoside Rb1(GRb1) bioavailability (BA). Phytosome complexes (F1, F2, and F3) were prepared by reacting GE with phospholipids in disparate ratios. F3 was chosen for preparing the phytosomes powder (PP) and phytosomes-loaded microspheres (PMs). Extract microspheres (EMs) were prepared by the addition of extract directly into the same polymer mixture. F3 gave enhanced entrapment efficiency (50.61%, w/w) along with spherical-shaped particle size (42.58 ± 1.4 nm) with the least polydispersity index (0.193 ± 0.01). PM showed an enhanced relative bioavailability (157.94%) of GRb1. It also showed a greater neuroprotective potential exhibiting significant (p < 0.05) augmentation in the nociceptive threshold. It was concluded that the PM system might be an optimistic and feasible strategy to enhance the delivery of GE for the effectual treatment of neuropathy.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:38 |
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| Enthalten in: |
Journal of microencapsulation - 38(2021), 7-8 vom: 16. Nov., Seite 496-506 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kumar, Nitin [VerfasserIn] |
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| Links: |
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| Themen: |
Ginsenoside |
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| Anmerkungen: |
Date Completed 13.01.2022 Date Revised 13.01.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1080/02652048.2021.1982042 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM330715348 |
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| 500 | |a Date Completed 13.01.2022 | ||
| 500 | |a Date Revised 13.01.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a The current research work focuses mainly on evolving a delivery system for ginseng extract (GE), which in turn will ameliorate the neuroprotective potential through enhancing the Ginsenoside Rb1(GRb1) bioavailability (BA). Phytosome complexes (F1, F2, and F3) were prepared by reacting GE with phospholipids in disparate ratios. F3 was chosen for preparing the phytosomes powder (PP) and phytosomes-loaded microspheres (PMs). Extract microspheres (EMs) were prepared by the addition of extract directly into the same polymer mixture. F3 gave enhanced entrapment efficiency (50.61%, w/w) along with spherical-shaped particle size (42.58 ± 1.4 nm) with the least polydispersity index (0.193 ± 0.01). PM showed an enhanced relative bioavailability (157.94%) of GRb1. It also showed a greater neuroprotective potential exhibiting significant (p < 0.05) augmentation in the nociceptive threshold. It was concluded that the PM system might be an optimistic and feasible strategy to enhance the delivery of GE for the effectual treatment of neuropathy | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Panax ginseng | |
| 650 | 4 | |a ginsenoside | |
| 650 | 4 | |a neuroprotective | |
| 650 | 4 | |a phytosomes | |
| 650 | 4 | |a saponins | |
| 650 | 7 | |a Phospholipids |2 NLM | |
| 650 | 7 | |a Plant Extracts |2 NLM | |
| 700 | 1 | |a Goel, Radha |e verfasserin |4 aut | |
| 700 | 1 | |a Gaur, Praveen Kumar |e verfasserin |4 aut | |
| 700 | 1 | |a Saxena, Prasoon Kumar |e verfasserin |4 aut | |
| 700 | 1 | |a Puri, Dinesh |e verfasserin |4 aut | |
| 700 | 1 | |a Chaudhary, Rahul |e verfasserin |4 aut | |
| 700 | 1 | |a Yasir, Mohd |e verfasserin |4 aut | |
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