Pd-catalysed general access to 7-membered N/O-heterocyclic compounds as potential agents against inflammation
A Pd-catalysed regioselective synthesis of 4,5-disubstituted 7-membered N/O-heterocycles was achieved via the 7-endo-dig cyclization followed by C-C bond formation of 2-(1-alkynyl)phenylacetamide. The ligand/additive free cascade reaction proceeded in the presence of PdCl2 in aqueous MeCN when the separate and individual use of methyl vinyl ketone and allyl bromide generally afforded an O- and N-heterocycle, respectively. The pharmacological assay was performed to identify the first example of a 1H-benzo[d]azepin-2(3H)-one based novel inhibitor of PDE4B.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:57 |
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| Enthalten in: |
Chemical communications (Cambridge, England) - 57(2021), 78 vom: 30. Sept., Seite 10091-10094 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Thirupataiah, B [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Completed 04.10.2021 Date Revised 04.10.2021 published: Electronic Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1039/d1cc04140a |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM330574620 |
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| 520 | |a A Pd-catalysed regioselective synthesis of 4,5-disubstituted 7-membered N/O-heterocycles was achieved via the 7-endo-dig cyclization followed by C-C bond formation of 2-(1-alkynyl)phenylacetamide. The ligand/additive free cascade reaction proceeded in the presence of PdCl2 in aqueous MeCN when the separate and individual use of methyl vinyl ketone and allyl bromide generally afforded an O- and N-heterocycle, respectively. The pharmacological assay was performed to identify the first example of a 1H-benzo[d]azepin-2(3H)-one based novel inhibitor of PDE4B | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Reddy, Gangireddy Sujeevan |e verfasserin |4 aut | |
| 700 | 1 | |a Mounika, Guntipally |e verfasserin |4 aut | |
| 700 | 1 | |a Kumar, Jetta Sandeep |e verfasserin |4 aut | |
| 700 | 1 | |a Hossain, Kazi Amirul |e verfasserin |4 aut | |
| 700 | 1 | |a Mudgal, Jayesh |e verfasserin |4 aut | |
| 700 | 1 | |a Mathew, Jessy E |e verfasserin |4 aut | |
| 700 | 1 | |a Shenoy, Gautham G |e verfasserin |4 aut | |
| 700 | 1 | |a Rajadurai, Marina |e verfasserin |4 aut | |
| 700 | 1 | |a Parsa, Kishore V L |e verfasserin |4 aut | |
| 700 | 1 | |a Pal, Manojit |e verfasserin |4 aut | |
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