Effect and underlying mechanism of morin on the pharmacokinetics of diclofenac sodium in rats
1. Morin, a natural flavonol, is present in many plants. It has anti-inflammatory and immunomodulatory activities and is often used as an adjuvant treatment for arthritis. Diclofenac sodium is the first-choice drug in the treatment of rheumatoid arthritis. However, the herb-drug interaction (HDI) between morin and diclofenac sodium remains unclear.2. The aim of the present research was to investigate whether and how morin affect the pharmacokinetic profile of diclofenac sodium.3. The enzyme kinetic and pharmacokinetic studies showed that morin significantly accelerated the metabolism and reduced systemic exposure of diclofenac sodium. Interestingly, the effect of morin on the pharmacokinetic profile of diclofenac sodium was not in a dose-dependent manner. Therefore, the effect of morin on P-glycoprotein (P-gp) was further investigated.4. The results implied that the influence mechanism of morin on the pharmacokinetic of diclofenac sodium might be related to CYP2C9 and P-gp. Attention should be paid to the risk of HDI between morin and diclofenac sodium in clinical practice.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:51 |
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| Enthalten in: |
Xenobiotica; the fate of foreign compounds in biological systems - 51(2021), 10 vom: 02. Okt., Seite 1181-1187 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Zhang, Jinghua [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 04.10.2021 Date Revised 04.10.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1080/00498254.2021.1979692 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| 245 | 1 | 0 | |a Effect and underlying mechanism of morin on the pharmacokinetics of diclofenac sodium in rats |
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| 500 | |a Date Revised 04.10.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a 1. Morin, a natural flavonol, is present in many plants. It has anti-inflammatory and immunomodulatory activities and is often used as an adjuvant treatment for arthritis. Diclofenac sodium is the first-choice drug in the treatment of rheumatoid arthritis. However, the herb-drug interaction (HDI) between morin and diclofenac sodium remains unclear.2. The aim of the present research was to investigate whether and how morin affect the pharmacokinetic profile of diclofenac sodium.3. The enzyme kinetic and pharmacokinetic studies showed that morin significantly accelerated the metabolism and reduced systemic exposure of diclofenac sodium. Interestingly, the effect of morin on the pharmacokinetic profile of diclofenac sodium was not in a dose-dependent manner. Therefore, the effect of morin on P-glycoprotein (P-gp) was further investigated.4. The results implied that the influence mechanism of morin on the pharmacokinetic of diclofenac sodium might be related to CYP2C9 and P-gp. Attention should be paid to the risk of HDI between morin and diclofenac sodium in clinical practice | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Morin | |
| 650 | 4 | |a P-gp | |
| 650 | 4 | |a diclofenac sodium | |
| 650 | 4 | |a metabolic enzymes | |
| 650 | 4 | |a pharmacokinetic | |
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| 650 | 7 | |a Anti-Inflammatory Agents, Non-Steroidal |2 NLM | |
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| 700 | 1 | |a Shao, Sennan |e verfasserin |4 aut | |
| 700 | 1 | |a Huang, Dan |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Jing |e verfasserin |4 aut | |
| 700 | 1 | |a Dai, Yue |e verfasserin |4 aut | |
| 700 | 1 | |a Wei, Zhifeng |e verfasserin |4 aut | |
| 700 | 1 | |a Xia, Yufeng |e verfasserin |4 aut | |
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