Developmental genetics of color pattern establishment in cats
© 2021. The Author(s)..
Intricate color patterns are a defining aspect of morphological diversity in the Felidae. We applied morphological and single-cell gene expression analysis to fetal skin of domestic cats to identify when, where, and how, during fetal development, felid color patterns are established. Early in development, we identify stripe-like alterations in epidermal thickness preceded by a gene expression pre-pattern. The secreted Wnt inhibitor encoded by Dickkopf 4 plays a central role in this process, and is mutated in cats with the Ticked pattern type. Our results bring molecular understanding to how the leopard got its spots, suggest that similar mechanisms underlie periodic color pattern and periodic hair follicle spacing, and identify targets for diverse pattern variation in other mammals.
| Errataetall: |
ErratumIn: Nat Commun. 2021 Sep 16;12(1):5584. - PMID 34531402 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
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| Enthalten in: |
Nature communications - 12(2021), 1 vom: 07. Sept., Seite 5127 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Kaelin, Christopher B [VerfasserIn] |
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| Links: |
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| Themen: |
Intercellular Signaling Peptides and Proteins |
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| Anmerkungen: |
Date Completed 13.09.2021 Date Revised 08.11.2023 published: Electronic ErratumIn: Nat Commun. 2021 Sep 16;12(1):5584. - PMID 34531402 Citation Status MEDLINE |
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| doi: |
10.1038/s41467-021-25348-2 |
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| 500 | |a ErratumIn: Nat Commun. 2021 Sep 16;12(1):5584. - PMID 34531402 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2021. The Author(s). | ||
| 520 | |a Intricate color patterns are a defining aspect of morphological diversity in the Felidae. We applied morphological and single-cell gene expression analysis to fetal skin of domestic cats to identify when, where, and how, during fetal development, felid color patterns are established. Early in development, we identify stripe-like alterations in epidermal thickness preceded by a gene expression pre-pattern. The secreted Wnt inhibitor encoded by Dickkopf 4 plays a central role in this process, and is mutated in cats with the Ticked pattern type. Our results bring molecular understanding to how the leopard got its spots, suggest that similar mechanisms underlie periodic color pattern and periodic hair follicle spacing, and identify targets for diverse pattern variation in other mammals | ||
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| 700 | 1 | |a Barsh, Gregory S |e verfasserin |4 aut | |
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