Association of Genetic Variants in miR-217 Gene with Risk of Coronary Artery Disease : A Case-Control Study
© 2021 Han et al..
OBJECTIVE: To evaluate the associations of genetic variants of the miR-217 gene with coronary artery disease (CAD) risk, as well as plasma level of vascular endothelial growth factor (VEGF).
METHODS: A case-control study with 498 CAD patients and 499 frequency-matched healthy controls was conducted to evaluate the associations of four tagSNPs of the miR-217 gene, including rs6724872, rs4999828, rs10206823, and rs41291177, with CAD risk and plasma level of VEGF.
RESULTS: SNP rs6724872 and rs4999828 were significantly associated with increased risk of CAD (P value was smaller than 0.05 even after Bonferroni multiple adjustment). Compared with the G allele, C allele of rs6724872 was significantly associated with 1.73-fold increased risk of CAD (95% CI: 1.25-2.39; P = 0.001). While C allele of rs4999828 was significantly associated with 1.75-fold increased risk of CAD, compared with T allele (95% CI: 1.34-2.29; P = 4 × 10-5). Meanwhile, rs6724872 and rs4999828 were also significantly associated with higher level of VEGF (P < 0.001).
CONCLUSION: These findings highlighted the important role of genetic variants of the miR-217 gene in the pathogenesis of CAD and potential targets for intervention.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:14 |
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| Enthalten in: |
Pharmacogenomics and personalized medicine - 14(2021) vom: 23., Seite 1081-1086 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Han, Xia [VerfasserIn] |
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| Anmerkungen: |
Date Revised 26.04.2022 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.2147/PGPM.S324767 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM330261002 |
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| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © 2021 Han et al. | ||
| 520 | |a OBJECTIVE: To evaluate the associations of genetic variants of the miR-217 gene with coronary artery disease (CAD) risk, as well as plasma level of vascular endothelial growth factor (VEGF) | ||
| 520 | |a METHODS: A case-control study with 498 CAD patients and 499 frequency-matched healthy controls was conducted to evaluate the associations of four tagSNPs of the miR-217 gene, including rs6724872, rs4999828, rs10206823, and rs41291177, with CAD risk and plasma level of VEGF | ||
| 520 | |a RESULTS: SNP rs6724872 and rs4999828 were significantly associated with increased risk of CAD (P value was smaller than 0.05 even after Bonferroni multiple adjustment). Compared with the G allele, C allele of rs6724872 was significantly associated with 1.73-fold increased risk of CAD (95% CI: 1.25-2.39; P = 0.001). While C allele of rs4999828 was significantly associated with 1.75-fold increased risk of CAD, compared with T allele (95% CI: 1.34-2.29; P = 4 × 10-5). Meanwhile, rs6724872 and rs4999828 were also significantly associated with higher level of VEGF (P < 0.001) | ||
| 520 | |a CONCLUSION: These findings highlighted the important role of genetic variants of the miR-217 gene in the pathogenesis of CAD and potential targets for intervention | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a VEGF | |
| 650 | 4 | |a coronary artery disease | |
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| 700 | 1 | |a Liang, Xiaotang |e verfasserin |4 aut | |
| 700 | 1 | |a Wu, Menghai |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Lijun |e verfasserin |4 aut | |
| 700 | 1 | |a Jiang, Honglei |e verfasserin |4 aut | |
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