Pooled analysis of recent studies of magnetic fields and childhood leukemia
Copyright © 2021 Elsevier Inc. All rights reserved..
BACKGROUND: Over forty epidemiologic studies have addressed an association between measured or calculated extremely-low-frequency magnetic fields (MF) and childhood leukemia. These studies have been aggregated in a series of pooled analyses, but it has been 10 years since the last such.
METHODS: We present a pooled analysis combining individual-level data (24,994 cases, 30,769 controls) from four recent studies on MF and childhood leukemia.
RESULTS: Unlike previous pooled analyses, we found no increased risk of leukemia among children exposed to greater MF: odds ratio (OR) = 1.01, for exposure ≥0.4 μT (μT) compared with exposures <0.1 μT. Similarly, no association was observed in the subset of acute lymphoblastic leukemia, birth homes, studies using calculated fields, or when geocoding accuracy was ignored. In these studies, there is a decline in risk over time, also evident when we compare three pooled analyses. A meta-analysis of the three pooled analyses overall presents an OR of 1.45 (95% CI: 0.95-2.20) for exposures ≥0.4 μT.
CONCLUSIONS: Our results are not in line with previous pooled analysis and show a decrease in effect to no association between MF and childhood leukemia. This could be due to methodological issues, random chance, or a true finding of disappearing effect.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:204 |
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| Enthalten in: |
Environmental research - 204(2022), Pt A vom: 15. März, Seite 111993 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Amoon, Aryana T [VerfasserIn] |
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| Links: |
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| Themen: |
Childhood leukemia |
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| Anmerkungen: |
Date Completed 07.01.2022 Date Revised 07.01.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.envres.2021.111993 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM330242482 |
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| 245 | 1 | 0 | |a Pooled analysis of recent studies of magnetic fields and childhood leukemia |
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| 500 | |a Date Revised 07.01.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2021 Elsevier Inc. All rights reserved. | ||
| 520 | |a BACKGROUND: Over forty epidemiologic studies have addressed an association between measured or calculated extremely-low-frequency magnetic fields (MF) and childhood leukemia. These studies have been aggregated in a series of pooled analyses, but it has been 10 years since the last such | ||
| 520 | |a METHODS: We present a pooled analysis combining individual-level data (24,994 cases, 30,769 controls) from four recent studies on MF and childhood leukemia | ||
| 520 | |a RESULTS: Unlike previous pooled analyses, we found no increased risk of leukemia among children exposed to greater MF: odds ratio (OR) = 1.01, for exposure ≥0.4 μT (μT) compared with exposures <0.1 μT. Similarly, no association was observed in the subset of acute lymphoblastic leukemia, birth homes, studies using calculated fields, or when geocoding accuracy was ignored. In these studies, there is a decline in risk over time, also evident when we compare three pooled analyses. A meta-analysis of the three pooled analyses overall presents an OR of 1.45 (95% CI: 0.95-2.20) for exposures ≥0.4 μT | ||
| 520 | |a CONCLUSIONS: Our results are not in line with previous pooled analysis and show a decrease in effect to no association between MF and childhood leukemia. This could be due to methodological issues, random chance, or a true finding of disappearing effect | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Meta-Analysis | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Childhood leukemia | |
| 650 | 4 | |a Electromagnetic fields | |
| 650 | 4 | |a Magnetic fields | |
| 650 | 4 | |a Pooled analysis | |
| 650 | 4 | |a Power lines | |
| 700 | 1 | |a Swanson, John |e verfasserin |4 aut | |
| 700 | 1 | |a Magnani, Corrado |e verfasserin |4 aut | |
| 700 | 1 | |a Johansen, Christoffer |e verfasserin |4 aut | |
| 700 | 1 | |a Kheifets, Leeka |e verfasserin |4 aut | |
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