Presentation and survival of gastro-entero-pancreatic neuroendocrine tumors in young adults versus older patients
Copyright © 2021 Elsevier Inc. All rights reserved..
BACKGROUND: A minority of patients with gastro-entero-pancreatic neuroendocrine tumors (GEP-NETs) is diagnosed at younger age. This population-based study explores the broad clinical and pathologic features of the youngest 5% of adult patients with GEP-NETs.
METHODS: A retrospective study of the National Cancer Database (NCDB) of patients with a primary GEP-NET was performed. Patients were stratified by age. Kaplan-Meier and multivariate Cox proportional hazards analyses were performed.
RESULTS: We identified 31,983 patients with a diagnosis of a GEP-NET and only 5% of patients were under the age of 35. Young patients were found to have greater proportions of localized, well differentiated disease. On multivariate analysis, young age, well differentiated histology, early stage, and surgical intervention were associated with lower risk of mortality.
CONCLUSIONS: Young patients with GEP-NETs tend to have earlier stage of presentation and well differentiated tumors, which may be most amenable to surgical intervention.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:223 |
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| Enthalten in: |
American journal of surgery - 223(2022), 5 vom: 01. Mai, Seite 939-944 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Nguyen, Andrew H [VerfasserIn] |
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| Links: |
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| Themen: |
Adolescent |
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| Anmerkungen: |
Date Completed 24.05.2022 Date Revised 14.06.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.amjsurg.2021.08.030 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM330174150 |
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| 245 | 1 | 0 | |a Presentation and survival of gastro-entero-pancreatic neuroendocrine tumors in young adults versus older patients |
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| 500 | |a Date Revised 14.06.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2021 Elsevier Inc. All rights reserved. | ||
| 520 | |a BACKGROUND: A minority of patients with gastro-entero-pancreatic neuroendocrine tumors (GEP-NETs) is diagnosed at younger age. This population-based study explores the broad clinical and pathologic features of the youngest 5% of adult patients with GEP-NETs | ||
| 520 | |a METHODS: A retrospective study of the National Cancer Database (NCDB) of patients with a primary GEP-NET was performed. Patients were stratified by age. Kaplan-Meier and multivariate Cox proportional hazards analyses were performed | ||
| 520 | |a RESULTS: We identified 31,983 patients with a diagnosis of a GEP-NET and only 5% of patients were under the age of 35. Young patients were found to have greater proportions of localized, well differentiated disease. On multivariate analysis, young age, well differentiated histology, early stage, and surgical intervention were associated with lower risk of mortality | ||
| 520 | |a CONCLUSIONS: Young patients with GEP-NETs tend to have earlier stage of presentation and well differentiated tumors, which may be most amenable to surgical intervention | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Adolescent | |
| 650 | 4 | |a Gastro-enteropancreatic neuroendocrine tumor | |
| 650 | 4 | |a Multivariable analysis | |
| 650 | 4 | |a Neuroendocrine tumors | |
| 650 | 4 | |a Retrospective studies | |
| 650 | 4 | |a Young adult | |
| 700 | 1 | |a O'Leary, Michael P |e verfasserin |4 aut | |
| 700 | 1 | |a De Andrade, James P |e verfasserin |4 aut | |
| 700 | 1 | |a Ituarte, Philip G |e verfasserin |4 aut | |
| 700 | 1 | |a Warner, Susanne G |e verfasserin |4 aut | |
| 700 | 1 | |a Melstrom, Laleh G |e verfasserin |4 aut | |
| 700 | 1 | |a Kessler, Jonathan |e verfasserin |4 aut | |
| 700 | 1 | |a Fong, Yuman |e verfasserin |4 aut | |
| 700 | 1 | |a Li, Daneng |e verfasserin |4 aut | |
| 700 | 1 | |a Singh, Gagandeep |e verfasserin |4 aut | |
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