Ventral pallidum regulates the default mode network, controlling transitions between internally and externally guided behavior
Daily life requires transitions between performance of well-practiced, automatized behaviors reliant upon internalized representations and behaviors requiring external focus. Such transitions involve differential activation of the default mode network (DMN), a group of brain areas associated with inward focus. We asked how optogenetic modulation of the ventral pallidum (VP), a subcortical DMN node, impacts task switching between internally to externally guided lever-pressing behavior in the rat. Excitation of the VP dramatically compromised acquisition of an auditory discrimination task, trapping animals in a DMN state of automatized internally focused behavior and impairing their ability to direct attention to external sensory stimuli. VP inhibition, on the other hand, facilitated task acquisition, expediting escape from the DMN brain state, thereby allowing rats to incorporate the contingency changes associated with the auditory stimuli. We suggest that VP, instant by instant, regulates the DMN and plays a deterministic role in transitions between internally and externally guided behaviors.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:118 |
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| Enthalten in: |
Proceedings of the National Academy of Sciences of the United States of America - 118(2021), 36 vom: 07. Sept. |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Klaassen, Arndt-Lukas [VerfasserIn] |
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| Links: |
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| Themen: |
Anterior cingulate cortex |
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| Anmerkungen: |
Date Completed 07.01.2022 Date Revised 01.03.2022 published: Print Citation Status MEDLINE |
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| doi: |
10.1073/pnas.2103642118 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM330051105 |
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| 245 | 1 | 0 | |a Ventral pallidum regulates the default mode network, controlling transitions between internally and externally guided behavior |
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| 500 | |a Date Revised 01.03.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Daily life requires transitions between performance of well-practiced, automatized behaviors reliant upon internalized representations and behaviors requiring external focus. Such transitions involve differential activation of the default mode network (DMN), a group of brain areas associated with inward focus. We asked how optogenetic modulation of the ventral pallidum (VP), a subcortical DMN node, impacts task switching between internally to externally guided lever-pressing behavior in the rat. Excitation of the VP dramatically compromised acquisition of an auditory discrimination task, trapping animals in a DMN state of automatized internally focused behavior and impairing their ability to direct attention to external sensory stimuli. VP inhibition, on the other hand, facilitated task acquisition, expediting escape from the DMN brain state, thereby allowing rats to incorporate the contingency changes associated with the auditory stimuli. We suggest that VP, instant by instant, regulates the DMN and plays a deterministic role in transitions between internally and externally guided behaviors | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a anterior cingulate cortex | |
| 650 | 4 | |a basal forebrain | |
| 650 | 4 | |a default mode network | |
| 650 | 4 | |a operant behavior | |
| 650 | 4 | |a ventral pallidum | |
| 700 | 1 | |a Heiniger, Anne |e verfasserin |4 aut | |
| 700 | 1 | |a Vaca Sánchez, Pilar |e verfasserin |4 aut | |
| 700 | 1 | |a Harvey, Michael A |e verfasserin |4 aut | |
| 700 | 1 | |a Rainer, Gregor |e verfasserin |4 aut | |
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