Kawasaki disease in children younger than 6 months of age : characteristics of a Spanish cohort
© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature..
A retrospective study that compared children younger than 6 months versus older children of a Spanish cohort of patients diagnosed with Kawasaki disease between 2011 and 2016 (Kawa-Race study). From the 598 patients recruited, 42 patients were younger than 6 months (7%) and presented more frequently with an incomplete diagnosis of Kawasaki disease (52.4 vs 27.9%, p = 0.001). Cardiac abnormalities detected by echocardiography were more common in younger patients (52.4 vs 30%, p = 0.002). These younger patients presented with a higher proportion of coronary aneurysms as well (19 vs 8.6%, p < 0.001). Shock at diagnosis (9.5 vs 1.9%, p = 0.016) and admission to intensive care units (17.7 vs 4.1%, p = 0.003) were more frequent in patients younger than 6 months. There were no statistically significant differences in relation to infections, non-response to IVIG, or mid- or long-term outcomes.Conclusion: Data of the Spanish cohort are consistent with other American and Asian studies, although Spanish children younger than 6 months had a lower rate of non-response to IVIG and better clinical outcomes. A high index of suspicion should be considered for this population due to a higher risk of coronary abnormalities, presentation of shock, and admission to the intensive care unit. What is Known: •Children below 6 months of age with Kawasaki disease (KD) have different features compared to older. •Younger patients usually have an incomplete form of KD and coronary artery abnormalities. What is New: •Younger than 6 months with KD presented with shock and required admission to PICU more frequently compared to older. •Infections play a similar role in KD despite the age of the patients.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:181 |
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| Enthalten in: |
European journal of pediatrics - 181(2022), 2 vom: 01. Feb., Seite 589-598 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Grasa, Carlos D [VerfasserIn] |
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| Links: |
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| Themen: |
6 months |
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| Anmerkungen: |
Date Completed 09.02.2022 Date Revised 09.02.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s00431-021-04215-8 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM330027565 |
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| 100 | 1 | |a Grasa, Carlos D |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Kawasaki disease in children younger than 6 months of age |b characteristics of a Spanish cohort |
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| 520 | |a © 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. | ||
| 520 | |a A retrospective study that compared children younger than 6 months versus older children of a Spanish cohort of patients diagnosed with Kawasaki disease between 2011 and 2016 (Kawa-Race study). From the 598 patients recruited, 42 patients were younger than 6 months (7%) and presented more frequently with an incomplete diagnosis of Kawasaki disease (52.4 vs 27.9%, p = 0.001). Cardiac abnormalities detected by echocardiography were more common in younger patients (52.4 vs 30%, p = 0.002). These younger patients presented with a higher proportion of coronary aneurysms as well (19 vs 8.6%, p < 0.001). Shock at diagnosis (9.5 vs 1.9%, p = 0.016) and admission to intensive care units (17.7 vs 4.1%, p = 0.003) were more frequent in patients younger than 6 months. There were no statistically significant differences in relation to infections, non-response to IVIG, or mid- or long-term outcomes.Conclusion: Data of the Spanish cohort are consistent with other American and Asian studies, although Spanish children younger than 6 months had a lower rate of non-response to IVIG and better clinical outcomes. A high index of suspicion should be considered for this population due to a higher risk of coronary abnormalities, presentation of shock, and admission to the intensive care unit. What is Known: •Children below 6 months of age with Kawasaki disease (KD) have different features compared to older. •Younger patients usually have an incomplete form of KD and coronary artery abnormalities. What is New: •Younger than 6 months with KD presented with shock and required admission to PICU more frequently compared to older. •Infections play a similar role in KD despite the age of the patients | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a 6 months | |
| 650 | 4 | |a Coronary aneurysm | |
| 650 | 4 | |a Kawasaki disease | |
| 650 | 4 | |a Pediatrics | |
| 650 | 4 | |a Shock | |
| 650 | 7 | |a Immunoglobulins, Intravenous |2 NLM | |
| 700 | 1 | |a Fernández-Cooke, Elisa |e verfasserin |4 aut | |
| 700 | 1 | |a Sánchez-Manubens, Judith |e verfasserin |4 aut | |
| 700 | 1 | |a Carazo-Gallego, Begoña |e verfasserin |4 aut | |
| 700 | 1 | |a Aracil-Santos, Javier |e verfasserin |4 aut | |
| 700 | 1 | |a Anton, Jordi |e verfasserin |4 aut | |
| 700 | 1 | |a Lirola, María José |e verfasserin |4 aut | |
| 700 | 1 | |a Mercader, Beatriz |e verfasserin |4 aut | |
| 700 | 1 | |a Villalobos, Enrique |e verfasserin |4 aut | |
| 700 | 1 | |a Bustillo, Matilde |e verfasserin |4 aut | |
| 700 | 1 | |a Giralt, Gemma |e verfasserin |4 aut | |
| 700 | 1 | |a Rocandio, Beatriz |e verfasserin |4 aut | |
| 700 | 1 | |a Escribano, Lucía M |e verfasserin |4 aut | |
| 700 | 1 | |a Domínguez-Rodríguez, Sara |e verfasserin |4 aut | |
| 700 | 1 | |a Calvo, Cristina |e verfasserin |4 aut | |
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