Dual-modality optical coherence tomography and fluorescence tethered capsule endomicroscopy
© 2021 Optical Society of America under the terms of the OSA Open Access Publishing Agreement..
OCT tethered capsule endomicroscopy (TCE) is an emerging noninvasive diagnostic imaging technology for gastrointestinal (GI) tract disorders. OCT measures tissue reflectivity that provides morphologic image contrast, and thus is incapable of ascertaining molecular information that can be useful for improving diagnostic accuracy. Here, we introduce an extension to OCT TCE that includes a fluorescence (FL) imaging channel for attaining complementary, co-registered molecular contrast. We present the development of an OCT-FL TCE capsule and a portable, plug-and-play OCT-FL imaging system. The technology is validated in phantom experiments and feasibility is demonstrated in a methylene blue (MB)-stained swine esophageal injury model, ex vivo and in vivo.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:12 |
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| Enthalten in: |
Biomedical optics express - 12(2021), 7 vom: 01. Juli, Seite 4308-4323 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Wartak, Andreas [VerfasserIn] |
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| Links: |
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| Themen: |
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| Anmerkungen: |
Date Revised 31.08.2021 published: Electronic-eCollection Citation Status PubMed-not-MEDLINE |
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| doi: |
10.1364/BOE.422453 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM330002317 |
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| 520 | |a © 2021 Optical Society of America under the terms of the OSA Open Access Publishing Agreement. | ||
| 520 | |a OCT tethered capsule endomicroscopy (TCE) is an emerging noninvasive diagnostic imaging technology for gastrointestinal (GI) tract disorders. OCT measures tissue reflectivity that provides morphologic image contrast, and thus is incapable of ascertaining molecular information that can be useful for improving diagnostic accuracy. Here, we introduce an extension to OCT TCE that includes a fluorescence (FL) imaging channel for attaining complementary, co-registered molecular contrast. We present the development of an OCT-FL TCE capsule and a portable, plug-and-play OCT-FL imaging system. The technology is validated in phantom experiments and feasibility is demonstrated in a methylene blue (MB)-stained swine esophageal injury model, ex vivo and in vivo | ||
| 650 | 4 | |a Journal Article | |
| 700 | 1 | |a Kelada, Alfred K |e verfasserin |4 aut | |
| 700 | 1 | |a Leon Alarcon, Paola A |e verfasserin |4 aut | |
| 700 | 1 | |a Bablouzian, Ara L |e verfasserin |4 aut | |
| 700 | 1 | |a Ahsen, Osman O |e verfasserin |4 aut | |
| 700 | 1 | |a Gregg, Abigail L |e verfasserin |4 aut | |
| 700 | 1 | |a Wei, Yuxiao |e verfasserin |4 aut | |
| 700 | 1 | |a Bollavaram, Keval |e verfasserin |4 aut | |
| 700 | 1 | |a Sheil, Conor J |e verfasserin |4 aut | |
| 700 | 1 | |a Farewell, Edward |e verfasserin |4 aut | |
| 700 | 1 | |a VanTol, Schuyler |e verfasserin |4 aut | |
| 700 | 1 | |a Smith, Rachel |e verfasserin |4 aut | |
| 700 | 1 | |a Grahmann, Patricia |e verfasserin |4 aut | |
| 700 | 1 | |a Baillargeon, Aaron R |e verfasserin |4 aut | |
| 700 | 1 | |a Gardecki, Joseph A |e verfasserin |4 aut | |
| 700 | 1 | |a Tearney, Guillermo J |e verfasserin |4 aut | |
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