Breast implant-associated EBV-positive diffuse large B-cell lymphoma : Two case reports and literature review
Copyright © 2021. Published by Elsevier GmbH..
Lymphomas associated with breast implants are mostly of the T-cell type. They are predominantly anaplastic lymphoma kinase-negative anaplastic large cell lymphoma (ALK-negative ALCL) characterized by CD30 positivity universally. Whilst the majority of primary breast lymphomas occurring in the absence of breast implants are of B-cell origin, there are few cases of implant-associated B-cell lymphomas reported to date in the literature, a subset of which are diffuse large B-cell lymphoma (DLBCL). Given the rarity of this entity, we describe two cases of breast implant-associated DLBCL. Both patients developed Epstein-Barr Virus (EBV)-positive large cell lymphoma of B-cell origin confined to the implant capsule with no evidence of systemic lymphoma. Considering the association with EBV, the activated B-cell phenotype and the presumed chronic inflammatory environment associated with the implant capsule, these might represent forms of DLBCL associated with chronic inflammation (DLBCL-CI) or fibrin-associated DLBCL (FA-DLBCL). Treatment included implant removal with total capsulectomy, and for one of the cases adjuvant systemic chemotherapy. Recognizing this rare type of breast implant-associated B-cell lymphoma could improve our understanding of this entity and hence develop appropriate management strategies.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:226 |
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| Enthalten in: |
Pathology, research and practice - 226(2021) vom: 05. Okt., Seite 153589 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Morgan, Sarah [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 28.01.2022 Date Revised 28.01.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.prp.2021.153589 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM329981811 |
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| 500 | |a Date Revised 28.01.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2021. Published by Elsevier GmbH. | ||
| 520 | |a Lymphomas associated with breast implants are mostly of the T-cell type. They are predominantly anaplastic lymphoma kinase-negative anaplastic large cell lymphoma (ALK-negative ALCL) characterized by CD30 positivity universally. Whilst the majority of primary breast lymphomas occurring in the absence of breast implants are of B-cell origin, there are few cases of implant-associated B-cell lymphomas reported to date in the literature, a subset of which are diffuse large B-cell lymphoma (DLBCL). Given the rarity of this entity, we describe two cases of breast implant-associated DLBCL. Both patients developed Epstein-Barr Virus (EBV)-positive large cell lymphoma of B-cell origin confined to the implant capsule with no evidence of systemic lymphoma. Considering the association with EBV, the activated B-cell phenotype and the presumed chronic inflammatory environment associated with the implant capsule, these might represent forms of DLBCL associated with chronic inflammation (DLBCL-CI) or fibrin-associated DLBCL (FA-DLBCL). Treatment included implant removal with total capsulectomy, and for one of the cases adjuvant systemic chemotherapy. Recognizing this rare type of breast implant-associated B-cell lymphoma could improve our understanding of this entity and hence develop appropriate management strategies | ||
| 650 | 4 | |a Case Reports | |
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Review | |
| 650 | 4 | |a Breast implant B-cell lymphoma | |
| 650 | 4 | |a DLBCL associated with chronic inflammation | |
| 650 | 4 | |a Diffuse large B-cell lymphoma (DLBCL) | |
| 650 | 4 | |a EBV-positive breast implant lymphoma | |
| 650 | 4 | |a Fibrin-associated DLBCL | |
| 700 | 1 | |a Tremblay-LeMay, Rosemarie |e verfasserin |4 aut | |
| 700 | 1 | |a Lipa, Joan E |e verfasserin |4 aut | |
| 700 | 1 | |a Sur, Monalisa |e verfasserin |4 aut | |
| 700 | 1 | |a Delabie, Jan |e verfasserin |4 aut | |
| 700 | 1 | |a Imrie, Kevin |e verfasserin |4 aut | |
| 700 | 1 | |a Crump, Michael |e verfasserin |4 aut | |
| 700 | 1 | |a Snell, Laura J |e verfasserin |4 aut | |
| 700 | 1 | |a Ghorab, Zeina |e verfasserin |4 aut | |
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