In-hospital and midterm post-discharge complications of adults hospitalised with respiratory syncytial virus infection in France, 2017-2019 : an observational study
Copyright ©The authors 2022. For reproduction rights and permissions contact permissionsersnet.org..
OBJECTIVES: The purpose of this study was to describe the clinical characteristics and in-hospital and post-discharge outcomes of respiratory syncytial virus (RSV) infection among adults hospitalised with influenza-like illness (ILI) and compared against patients admitted for influenza.
METHODS: Adults hospitalised with ILI were prospectively included from five French university hospitals over two consecutive winter seasons (2017/2018 and 2018/2019). RSV and influenza virus were detected by multiplex reverse transcription PCR on nasopharyngeal swabs. RSV-positive patients were compared to RSV-negative and influenza-positive hospitalised patients. Poisson regression models were used to estimate the adjusted prevalence ratio (aPR) associated with in-hospital and post-discharge outcomes between RSV and influenza infections. The in-hospital outcome was a composite of the occurrence of at least one complication, length of stay ≥7 days, intensive care unit admission, use of mechanical ventilation and in-hospital death. Post-discharge outcome included 30- and 90-day all-cause mortality and 90-day readmission rates.
RESULTS: Overall, 1428 hospitalised adults with ILI were included. RSV was detected in 8% (114 of 1428) and influenza virus in 31% (437 of 1428). Patients hospitalised with RSV were older than those with influenza (mean age 73.0 versus 68.8 years, p=0.015) with a higher frequency of chronic respiratory or cardiac disease (52% versus 39%, p=0.012, and 52% versus 41%, p=0.039, respectively) and longer hospitalisation duration (median stay 8 versus 6 days, p<0.001). Anti-influenza therapies were less prescribed among RSV patients than influenza patients (20% versus 66%, p<0.001). In-hospital composite outcome was poorer in RSV patients (aPR 1.5, 95% CI 1.1-2.1) than in those hospitalised with influenza. No difference was observed for the post-discharge composite outcome (aPR 1.1, 95% CI 0.8-1.6).
CONCLUSION: RSV infection results in serious respiratory illness, with worse in-hospital outcomes than influenza and with similar midterm post-discharge outcomes.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:59 |
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| Enthalten in: |
The European respiratory journal - 59(2022), 3 vom: 26. März |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Descamps, Alexandre [VerfasserIn] |
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| Links: |
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| Themen: |
Journal Article |
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| Anmerkungen: |
Date Completed 06.04.2022 Date Revised 06.04.2022 published: Electronic-Print Citation Status MEDLINE |
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| doi: |
10.1183/13993003.00651-2021 |
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| Förderinstitution / Projekttitel: |
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NLM32989370X |
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| 100 | 1 | |a Descamps, Alexandre |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a In-hospital and midterm post-discharge complications of adults hospitalised with respiratory syncytial virus infection in France, 2017-2019 |b an observational study |
| 264 | 1 | |c 2022 | |
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| 500 | |a Date Completed 06.04.2022 | ||
| 500 | |a Date Revised 06.04.2022 | ||
| 500 | |a published: Electronic-Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright ©The authors 2022. For reproduction rights and permissions contact permissionsersnet.org. | ||
| 520 | |a OBJECTIVES: The purpose of this study was to describe the clinical characteristics and in-hospital and post-discharge outcomes of respiratory syncytial virus (RSV) infection among adults hospitalised with influenza-like illness (ILI) and compared against patients admitted for influenza | ||
| 520 | |a METHODS: Adults hospitalised with ILI were prospectively included from five French university hospitals over two consecutive winter seasons (2017/2018 and 2018/2019). RSV and influenza virus were detected by multiplex reverse transcription PCR on nasopharyngeal swabs. RSV-positive patients were compared to RSV-negative and influenza-positive hospitalised patients. Poisson regression models were used to estimate the adjusted prevalence ratio (aPR) associated with in-hospital and post-discharge outcomes between RSV and influenza infections. The in-hospital outcome was a composite of the occurrence of at least one complication, length of stay ≥7 days, intensive care unit admission, use of mechanical ventilation and in-hospital death. Post-discharge outcome included 30- and 90-day all-cause mortality and 90-day readmission rates | ||
| 520 | |a RESULTS: Overall, 1428 hospitalised adults with ILI were included. RSV was detected in 8% (114 of 1428) and influenza virus in 31% (437 of 1428). Patients hospitalised with RSV were older than those with influenza (mean age 73.0 versus 68.8 years, p=0.015) with a higher frequency of chronic respiratory or cardiac disease (52% versus 39%, p=0.012, and 52% versus 41%, p=0.039, respectively) and longer hospitalisation duration (median stay 8 versus 6 days, p<0.001). Anti-influenza therapies were less prescribed among RSV patients than influenza patients (20% versus 66%, p<0.001). In-hospital composite outcome was poorer in RSV patients (aPR 1.5, 95% CI 1.1-2.1) than in those hospitalised with influenza. No difference was observed for the post-discharge composite outcome (aPR 1.1, 95% CI 0.8-1.6) | ||
| 520 | |a CONCLUSION: RSV infection results in serious respiratory illness, with worse in-hospital outcomes than influenza and with similar midterm post-discharge outcomes | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 700 | 1 | |a Lenzi, Nezha |e verfasserin |4 aut | |
| 700 | 1 | |a Galtier, Florence |e verfasserin |4 aut | |
| 700 | 1 | |a Lainé, Fabrice |e verfasserin |4 aut | |
| 700 | 1 | |a Lesieur, Zineb |e verfasserin |4 aut | |
| 700 | 1 | |a Vanhems, Philippe |e verfasserin |4 aut | |
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| 700 | 1 | |a L'Honneur, Anne-Sophie |e verfasserin |4 aut | |
| 700 | 1 | |a Fidouh, Nadhira |e verfasserin |4 aut | |
| 700 | 1 | |a Foulongne, Vincent |e verfasserin |4 aut | |
| 700 | 1 | |a Lagathu, Gisèle |e verfasserin |4 aut | |
| 700 | 1 | |a Duval, Xavier |e verfasserin |4 aut | |
| 700 | 1 | |a Merle, Corinne |e verfasserin |4 aut | |
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| 700 | 1 | |a Loubet, Paul |e verfasserin |4 aut | |
| 700 | 0 | |a FLUVAC study group |e verfasserin |4 aut | |
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