IgM-enriched immunoglobulin in COVID-19 : Case series of 15 severely ill SARS-CoV-2-infected patients

Copyright © 2021. Published by Elsevier B.V..

The healthcare system in Iran, like most around the world, is managing thousands of patients hospitalised with COVID-19. In Iran, in-hospital mortality is in the region of 25%, rising to 50-60% in patients admitted to intensive care. Hyperinflammation, characterised by cytokine storm, appears to be a hallmark of severe COVID-19 and to date only the anti-inflammatory drug dexamethasone has been shown to reduce mortality in those hospitalised with the disease. There is a sound scientific rationale behind the use of IgM-enriched immunoglobulin in the management of patients with severe COVID-19. It has been used successfully in the management of hyperinflammation in patients with sepsis and has led to improved radiographic scores in patients with severe cases of severe acute respiratory syndrome coronavirus (SARS-CoV) infection. Recently the successful treatment of a patient with COVID-19 with IgM-enriched immunoglobulin was reported. Here we report the outcome of a further 15 patients hospitalised with COVID-19 treated with IgM-enriched immunoglobulin. Improvements in computed tomography (CT) score were observed in nine patients, indicating that further clinical studies into the use of IgM-enriched immunoglobulin in the treatment of severe COVID-19 are warranted.

Media Type:

Electronic Article

Year of Publication:

2021

Contained In:

International immunopharmacology - Vol. 99 (2021), p. 107998

Language:

English

Contributors:

Tabarsi, Payam
Hashemian, Seyed Mohammad Reza
Bauhofer, Artur
Savadkoohi, Ali Amir
Ghadimi, Somayeh
Haseli, Sara
Dastan, Farzaneh

Links:

Volltext

Keywords:

COVID-19
Cytokine storm
Hyperinflammation
IgM-enriched immunoglobulin
Intravenous immunoglobulin (IVIG)
Journal Article
SARS-CoV-2

Notes:

Date Revised 08.09.2021

published: Print-Electronic

Citation Status In-Process

Copyright: From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Physical Description:

Online-Ressource

doi:

10.1016/j.intimp.2021.107998

PMID:

34315117

PPN (Catalogue-ID):

NLM329766988