The impact of medical therapies and factors related to treatment procedures in women with rheumatoid arthritis and inflammatory bowel disease receiving assisted reproduction : a nationwide cohort study
Copyright © 2021 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved..
OBJECTIVE: To examine whether medications used to treat rheumatoid arthritis (RA)/chronic inflammatory bowel disease (IBD), or factors related to the assisted reproductive technology (ART) procedures, impact the success of ART. In women with RA/IBD, initial studies have shown a reduced chance of a live-born child after ART.
DESIGN: Cohort study.
SETTING: Nationwide Danish health registries.
PATIENTS: All Danish women with a fresh embryo transfer from January 1, 2006, through 2018. The cohorts comprised 1,824 embryo transfers in women with RA/IBD and 97,191 embryo transfers in women without RA/IBD.
INTERVENTIONS: Observational, noninterventional study.
MAIN OUTCOME MEASURE: Live birth per fresh embryo transfer.
RESULTS: The chance of a live birth in women with RA/IBD receiving ART, compared with other women receiving ART, had an adjusted odds ratio (OR) of 0.79 (95% confidence interval [CI], 0.68-0.91). Prescribed corticosteroids before embryo transfer were positively associated with a live-born child (adjusted OR, 1.21; 95% CI, 1.12-1.31), while the use of antiinflammatory/immunosuppressive agents did not have significant importance. Intracytoplasmic sperm injection was associated with a reduced chance (adjusted OR, 0.94; 95% CI, 0.90-0.97). Type of hormone treatment protocol did not have significant importance, and transfer at the blastocyst stage was positively associated with a live-born child (adjusted OR, 1.54; 95% CI, 1.46-1.62).
CONCLUSIONS: In women with RA and/or IBD, prescribed corticosteroid before embryo transfer and embryo transfer at the blastocyst stage were associated with successful ART. Intracytoplasmic sperm injection was associated with a slightly reduced chance. Antiinflammatory/immunosuppressive agents and type of hormone protocols did not have significant importance.
| Errataetall: |
CommentIn: Fertil Steril. 2021 Dec;116(6):1501. - PMID 34742562 |
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| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:116 |
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| Enthalten in: |
Fertility and sterility - 116(2021), 6 vom: 15. Dez., Seite 1492-1500 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Nørgård, Bente Mertz [VerfasserIn] |
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| Links: |
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| Themen: |
ART |
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| Anmerkungen: |
Date Completed 21.12.2021 Date Revised 21.12.2021 published: Print-Electronic CommentIn: Fertil Steril. 2021 Dec;116(6):1501. - PMID 34742562 Citation Status MEDLINE |
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| doi: |
10.1016/j.fertnstert.2021.07.1198 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM329766791 |
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| 245 | 1 | 4 | |a The impact of medical therapies and factors related to treatment procedures in women with rheumatoid arthritis and inflammatory bowel disease receiving assisted reproduction |b a nationwide cohort study |
| 264 | 1 | |c 2021 | |
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| 500 | |a Date Completed 21.12.2021 | ||
| 500 | |a Date Revised 21.12.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a CommentIn: Fertil Steril. 2021 Dec;116(6):1501. - PMID 34742562 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2021 American Society for Reproductive Medicine. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a OBJECTIVE: To examine whether medications used to treat rheumatoid arthritis (RA)/chronic inflammatory bowel disease (IBD), or factors related to the assisted reproductive technology (ART) procedures, impact the success of ART. In women with RA/IBD, initial studies have shown a reduced chance of a live-born child after ART | ||
| 520 | |a DESIGN: Cohort study | ||
| 520 | |a SETTING: Nationwide Danish health registries | ||
| 520 | |a PATIENTS: All Danish women with a fresh embryo transfer from January 1, 2006, through 2018. The cohorts comprised 1,824 embryo transfers in women with RA/IBD and 97,191 embryo transfers in women without RA/IBD | ||
| 520 | |a INTERVENTIONS: Observational, noninterventional study | ||
| 520 | |a MAIN OUTCOME MEASURE: Live birth per fresh embryo transfer | ||
| 520 | |a RESULTS: The chance of a live birth in women with RA/IBD receiving ART, compared with other women receiving ART, had an adjusted odds ratio (OR) of 0.79 (95% confidence interval [CI], 0.68-0.91). Prescribed corticosteroids before embryo transfer were positively associated with a live-born child (adjusted OR, 1.21; 95% CI, 1.12-1.31), while the use of antiinflammatory/immunosuppressive agents did not have significant importance. Intracytoplasmic sperm injection was associated with a reduced chance (adjusted OR, 0.94; 95% CI, 0.90-0.97). Type of hormone treatment protocol did not have significant importance, and transfer at the blastocyst stage was positively associated with a live-born child (adjusted OR, 1.54; 95% CI, 1.46-1.62) | ||
| 520 | |a CONCLUSIONS: In women with RA and/or IBD, prescribed corticosteroid before embryo transfer and embryo transfer at the blastocyst stage were associated with successful ART. Intracytoplasmic sperm injection was associated with a slightly reduced chance. Antiinflammatory/immunosuppressive agents and type of hormone protocols did not have significant importance | ||
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| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
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| 650 | 4 | |a inflammatory bowel disease | |
| 650 | 4 | |a live birth | |
| 650 | 4 | |a rheumatoid arthritis | |
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| 700 | 1 | |a Larsen, Michael Due |e verfasserin |4 aut | |
| 700 | 1 | |a Friedman, Sonia |e verfasserin |4 aut | |
| 700 | 1 | |a Jølving, Line Riis |e verfasserin |4 aut | |
| 700 | 1 | |a Fedder, Jens |e verfasserin |4 aut | |
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