Aneurysm morphological prediction of intracranial aneurysm rupture in elderly patients using four-dimensional CT angiography
Copyright © 2021 Elsevier B.V. All rights reserved..
OBJECTIVE: The natural history of unruptured intracranial aneurysms (UIAs) in elderly patients remains poorly understood, and the treatment of UIAs is controversial. The presence of irregular pulsation detected by four-dimensional CT angiography (4D-CTA) is associated with ruptured aneurysms. We aimed to investigate the morphological predictors of irregular pulsation of aneurysms in elderly patients.
PATIENTS AND METHODS: We performed a prospective study of intracranial aneurysms detected by 4D-CTA. Elderly patients were defined as those more than 60 years of age. The irregular pulsation was defined as a focal protuberance during a cardiac cycle. We performed multivariate analyses to determine the associations of clinical characteristics and aneurysm morphologies with the irregular pulsation of aneurysms.
RESULTS: A total of 128 elderly patients with 166 intracranial aneurysms was included. The irregular pulsation occurred in 71 (42.8%) aneurysms. The multivariate analysis showed that a large size ratio (p = 0.006), posterior circulation aneurysms (p = 0.033), the presence of a daughter dome (p = 0.006), and aneurysm rupture (p = 0.032) were independently associated with the irregular pulsation. The multivariate analysis of predictors of irregular pulsation of unruptured aneurysms showed that size ratio (p = 0.01) and the presence of a daughter dome (p = 0.016) were independent predictors of irregular pulsation.
CONCLUSION: A large size ratio, posterior circulation aneurysms, the presence of a daughter dome, and aneurysm rupture were independent predictors of the irregular pulsation of aneurysms in elderly patients. The morphological characteristics detected by 4D-CTA may be helpful to evaluate the risk of rupture of aneurysms.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:208 |
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| Enthalten in: |
Clinical neurology and neurosurgery - 208(2021) vom: 25. Sept., Seite 106877 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Cui, Yudi [VerfasserIn] |
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| Links: |
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| Themen: |
4D-CT angiography |
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| Anmerkungen: |
Date Completed 25.01.2022 Date Revised 25.01.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.clineuro.2021.106877 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM329718517 |
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| 245 | 1 | 0 | |a Aneurysm morphological prediction of intracranial aneurysm rupture in elderly patients using four-dimensional CT angiography |
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| 500 | |a Date Revised 25.01.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2021 Elsevier B.V. All rights reserved. | ||
| 520 | |a OBJECTIVE: The natural history of unruptured intracranial aneurysms (UIAs) in elderly patients remains poorly understood, and the treatment of UIAs is controversial. The presence of irregular pulsation detected by four-dimensional CT angiography (4D-CTA) is associated with ruptured aneurysms. We aimed to investigate the morphological predictors of irregular pulsation of aneurysms in elderly patients | ||
| 520 | |a PATIENTS AND METHODS: We performed a prospective study of intracranial aneurysms detected by 4D-CTA. Elderly patients were defined as those more than 60 years of age. The irregular pulsation was defined as a focal protuberance during a cardiac cycle. We performed multivariate analyses to determine the associations of clinical characteristics and aneurysm morphologies with the irregular pulsation of aneurysms | ||
| 520 | |a RESULTS: A total of 128 elderly patients with 166 intracranial aneurysms was included. The irregular pulsation occurred in 71 (42.8%) aneurysms. The multivariate analysis showed that a large size ratio (p = 0.006), posterior circulation aneurysms (p = 0.033), the presence of a daughter dome (p = 0.006), and aneurysm rupture (p = 0.032) were independently associated with the irregular pulsation. The multivariate analysis of predictors of irregular pulsation of unruptured aneurysms showed that size ratio (p = 0.01) and the presence of a daughter dome (p = 0.016) were independent predictors of irregular pulsation | ||
| 520 | |a CONCLUSION: A large size ratio, posterior circulation aneurysms, the presence of a daughter dome, and aneurysm rupture were independent predictors of the irregular pulsation of aneurysms in elderly patients. The morphological characteristics detected by 4D-CTA may be helpful to evaluate the risk of rupture of aneurysms | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a 4D-CT angiography | |
| 650 | 4 | |a Elderly patients | |
| 650 | 4 | |a Intracranial aneurysm | |
| 650 | 4 | |a Risk factor | |
| 650 | 4 | |a Rupture | |
| 700 | 1 | |a Xing, Haixia |e verfasserin |4 aut | |
| 700 | 1 | |a Zhou, Jiafeng |e verfasserin |4 aut | |
| 700 | 1 | |a Chen, Yongchun |e verfasserin |4 aut | |
| 700 | 1 | |a Lin, Boli |e verfasserin |4 aut | |
| 700 | 1 | |a Ding, Shenghao |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Huilin |e verfasserin |4 aut | |
| 700 | 1 | |a Pan, Yaohua |e verfasserin |4 aut | |
| 700 | 1 | |a Wan, Jieqing |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Xiaohua |e verfasserin |4 aut | |
| 700 | 1 | |a Zhao, Bing |e verfasserin |4 aut | |
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