Impact of cardiovascular burden on coagulation pathway in apparently healthy women planning oocyte donation
BACKGROUND: Hormonal fertility treatments are associated with increased coagulation factors inducing procoagulant milieu and possibly thrombotic risk.
OBJECTIVE: To assess coagulation by ROTEM and coagulation tests in apparently healthy infertile women before oocyte donation procedure.
METHODS: We enrolled 51 women (Assisted Reproductive Technology Centre, Florence). ROTEM and coagulation parameters were assessed before the start of infertility treatment.
RESULTS: We divided women in 3 groups according to the number of cardiovascular risk factors: Group A (n = 10), Group B (n = 16), and Group C (n = 25). By considering ROTEM Extem test, a significantly increased of MCF, TPI, and G were observed in groups B (p = 0.005, p = 0.03, and p = 0.007) and C (p = 0.01, p = 0.05, and p = 0.005) in comparison to group A. As regards ROTEM Intem test, the TPI and G values were significantly higher in groups B and C in comparison to group A (p < 0.01). MCF by Fibtem test significantly increased in groups B and C than in group A (p = 0.004 and p = 0.002, respectively). FVIII, vWF:Ag and D-dimer values significantly increase according to the presence of≥2 risk factors.
CONCLUSIONS: Data from coagulative assessment permit to sensitively identify women with potentially procoagulable state, which represents a risk factor of thromboembolic event during hormone treatment.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:79 |
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| Enthalten in: |
Clinical hemorheology and microcirculation - 79(2021), 4 vom: 13., Seite 531-539 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Cirillo, Michela [VerfasserIn] |
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| Links: |
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| Themen: |
Assisted reproductive techniques |
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| Anmerkungen: |
Date Completed 04.01.2022 Date Revised 04.01.2022 published: Print Citation Status MEDLINE |
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| doi: |
10.3233/CH-211108 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM329643010 |
|---|
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| 245 | 1 | 0 | |a Impact of cardiovascular burden on coagulation pathway in apparently healthy women planning oocyte donation |
| 264 | 1 | |c 2021 | |
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| 500 | |a Date Completed 04.01.2022 | ||
| 500 | |a Date Revised 04.01.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a BACKGROUND: Hormonal fertility treatments are associated with increased coagulation factors inducing procoagulant milieu and possibly thrombotic risk | ||
| 520 | |a OBJECTIVE: To assess coagulation by ROTEM and coagulation tests in apparently healthy infertile women before oocyte donation procedure | ||
| 520 | |a METHODS: We enrolled 51 women (Assisted Reproductive Technology Centre, Florence). ROTEM and coagulation parameters were assessed before the start of infertility treatment | ||
| 520 | |a RESULTS: We divided women in 3 groups according to the number of cardiovascular risk factors: Group A (n = 10), Group B (n = 16), and Group C (n = 25). By considering ROTEM Extem test, a significantly increased of MCF, TPI, and G were observed in groups B (p = 0.005, p = 0.03, and p = 0.007) and C (p = 0.01, p = 0.05, and p = 0.005) in comparison to group A. As regards ROTEM Intem test, the TPI and G values were significantly higher in groups B and C in comparison to group A (p < 0.01). MCF by Fibtem test significantly increased in groups B and C than in group A (p = 0.004 and p = 0.002, respectively). FVIII, vWF:Ag and D-dimer values significantly increase according to the presence of≥2 risk factors | ||
| 520 | |a CONCLUSIONS: Data from coagulative assessment permit to sensitively identify women with potentially procoagulable state, which represents a risk factor of thromboembolic event during hormone treatment | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Oocyte donation | |
| 650 | 4 | |a assisted reproductive techniques | |
| 650 | 4 | |a blood coagulation tests | |
| 650 | 4 | |a hemostasis | |
| 650 | 4 | |a women’s health | |
| 700 | 1 | |a Attanasio, Monica |e verfasserin |4 aut | |
| 700 | 1 | |a Paniccia, Rita |e verfasserin |4 aut | |
| 700 | 1 | |a Rizzello, Francesca |e verfasserin |4 aut | |
| 700 | 1 | |a Coccia, Maria Elisabetta |e verfasserin |4 aut | |
| 700 | 1 | |a Fatini, Cinzia |e verfasserin |4 aut | |
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