Seroprevalence and risk factors for SARS-CoV-2 Infection in selected urban areas in Ethiopia : a cross-sectional evaluation during July 2020
Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved..
BACKGROUND: Ethiopia reported the first case of COVID-19 on 13th March, 2020 with community transmission ensuing by mid-May. A national, population-based serosurvey against anti-SARS-CoV-2 IgG was conducted to measure the prevalence of prior COVID-19 infections and better approximate the burden across major towns in Ethiopia.
METHODS: We conducted a cross-sectional, population-based serosurvey from June 24 to July 8, 2020 in 14 major urban areas. Two-stage cluster sampling was used to randomly select enumeration areas and households. All persons aged ≥15 years were enrolled. Serum samples were tested by Abbott™ ARCHITECT™ assay for SARS-CoV-2 IgG antibodies. National COVID-19 surveillance data on the median date of the serosurvey is analyzed for comparison.
FINDINGS: Adjusted seroprevalence was 3.5% (95% CI: 3.2%-3.8%) after controlling for age, sex and test kit performance. Males (3.7%) and females (3.3%) were nearly equally infected, while middle-aged adults '40-65 years' had the highest (4.0%) prevalence. Gambella (7.5%), Dire Dawa (6.2%) and Jigjiga (6.1%) were the most affected towns. About 6.7% and 8.0% of seropositives had symptoms and chronic underlying illness, respectively. A surveillance system had identified 4,416 RT-PCR confirmed cases in Addis Ababa.
INTERPRETATION: This serosurvey shows that a majority of urban Ethiopians remain uninfected with SARS-CoV-2. Most anti-SARS-CoV-2 IgG positive cases were asymptomatic with no underlying illness, keeping case detection to a minimum.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:111 |
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| Enthalten in: |
International journal of infectious diseases : IJID : official publication of the International Society for Infectious Diseases - 111(2021) vom: 01. Okt., Seite 179-185 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Tadesse, Enyew Birru [VerfasserIn] |
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| Links: |
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| Themen: |
Coronavirus Infections / epidemiology |
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| Anmerkungen: |
Date Completed 07.10.2021 Date Revised 07.11.2023 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.ijid.2021.08.028 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM329551760 |
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| 245 | 1 | 0 | |a Seroprevalence and risk factors for SARS-CoV-2 Infection in selected urban areas in Ethiopia |b a cross-sectional evaluation during July 2020 |
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| 500 | |a published: Print-Electronic | ||
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| 520 | |a Copyright © 2021 The Authors. Published by Elsevier Ltd.. All rights reserved. | ||
| 520 | |a BACKGROUND: Ethiopia reported the first case of COVID-19 on 13th March, 2020 with community transmission ensuing by mid-May. A national, population-based serosurvey against anti-SARS-CoV-2 IgG was conducted to measure the prevalence of prior COVID-19 infections and better approximate the burden across major towns in Ethiopia | ||
| 520 | |a METHODS: We conducted a cross-sectional, population-based serosurvey from June 24 to July 8, 2020 in 14 major urban areas. Two-stage cluster sampling was used to randomly select enumeration areas and households. All persons aged ≥15 years were enrolled. Serum samples were tested by Abbott™ ARCHITECT™ assay for SARS-CoV-2 IgG antibodies. National COVID-19 surveillance data on the median date of the serosurvey is analyzed for comparison | ||
| 520 | |a FINDINGS: Adjusted seroprevalence was 3.5% (95% CI: 3.2%-3.8%) after controlling for age, sex and test kit performance. Males (3.7%) and females (3.3%) were nearly equally infected, while middle-aged adults '40-65 years' had the highest (4.0%) prevalence. Gambella (7.5%), Dire Dawa (6.2%) and Jigjiga (6.1%) were the most affected towns. About 6.7% and 8.0% of seropositives had symptoms and chronic underlying illness, respectively. A surveillance system had identified 4,416 RT-PCR confirmed cases in Addis Ababa | ||
| 520 | |a INTERPRETATION: This serosurvey shows that a majority of urban Ethiopians remain uninfected with SARS-CoV-2. Most anti-SARS-CoV-2 IgG positive cases were asymptomatic with no underlying illness, keeping case detection to a minimum | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Coronavirus Infections / epidemiology | |
| 650 | 4 | |a Ethiopia / epidemiology | |
| 650 | 4 | |a Immunoglobulin G / blood | |
| 650 | 4 | |a Seroepidemiological Studies | |
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| 700 | 1 | |a Alayu, Mikias |e verfasserin |4 aut | |
| 700 | 1 | |a Kebede, Adisu |e verfasserin |4 aut | |
| 700 | 1 | |a Eshetu, Kirubel |e verfasserin |4 aut | |
| 700 | 1 | |a Teka, Gizaw |e verfasserin |4 aut | |
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| 700 | 1 | |a Ahmed, Jelaludin |e verfasserin |4 aut | |
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| 700 | 1 | |a Sugerman, David |e verfasserin |4 aut | |
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| 700 | 1 | |a Abate, Ebba |e verfasserin |4 aut | |
| 700 | 1 | |a Taddese, Lia |e verfasserin |4 aut | |
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