Fibrinogen measurement by a novel point-of-care device with whole blood : comparison of values against Clauss method
© 2021. Japanese Society of Anesthesiologists..
Timely fibrinogen replacement is key to treating critical hemorrhage. Measuring fibrinogen concentration by conventional laboratory tests requires centrifugation of blood samples and is often time-consuming. A point-of-care testing device (A&T, Yokohama, Japan), CG02N, has been available in Japan since 2011 to measure fibrinogen concentration without centrifugation. However, it has not been widely used as it requires dilution of blood samples using manual micropipetting. To further speed up and simplify the fibrinogen measurement, an improved device called FibCare (Atom Medical, Tokyo, Japan) was developed to avoid diluting blood samples. The purpose of this study is to verify the reliability of FibCare against laboratory measurement using the Clauss method. Fibrinogen concentrations with 60 sodium citrated whole blood samples were measured by both FibCare and Clauss methods in the laboratory. Measured values with the Clauss method were distributed in the 88-300 mg/dL range. By comparing these results, a significant positive correlation was observed between the FibCare and Clauss method (Y = 12.402 + 0.982 X; R = 0.891; P < 0.01). The study indicated that FibCare allows accurate measurement of fibrinogen concentration and shows a possibility to contribute to optimal fibrinogen replacement therapy during critical hemorrhage.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:35 |
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| Enthalten in: |
Journal of anesthesia - 35(2021), 5 vom: 09. Okt., Seite 757-760 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Okahara, Shoko [VerfasserIn] |
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| Links: |
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| Themen: |
9001-32-5 |
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| Anmerkungen: |
Date Completed 20.10.2021 Date Revised 26.10.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s00540-021-02987-9 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM329539337 |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2021. Japanese Society of Anesthesiologists. | ||
| 520 | |a Timely fibrinogen replacement is key to treating critical hemorrhage. Measuring fibrinogen concentration by conventional laboratory tests requires centrifugation of blood samples and is often time-consuming. A point-of-care testing device (A&T, Yokohama, Japan), CG02N, has been available in Japan since 2011 to measure fibrinogen concentration without centrifugation. However, it has not been widely used as it requires dilution of blood samples using manual micropipetting. To further speed up and simplify the fibrinogen measurement, an improved device called FibCare (Atom Medical, Tokyo, Japan) was developed to avoid diluting blood samples. The purpose of this study is to verify the reliability of FibCare against laboratory measurement using the Clauss method. Fibrinogen concentrations with 60 sodium citrated whole blood samples were measured by both FibCare and Clauss methods in the laboratory. Measured values with the Clauss method were distributed in the 88-300 mg/dL range. By comparing these results, a significant positive correlation was observed between the FibCare and Clauss method (Y = 12.402 + 0.982 X; R = 0.891; P < 0.01). The study indicated that FibCare allows accurate measurement of fibrinogen concentration and shows a possibility to contribute to optimal fibrinogen replacement therapy during critical hemorrhage | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Clauss method | |
| 650 | 4 | |a FibCare | |
| 650 | 4 | |a Fibrinogen | |
| 650 | 4 | |a Hemorrhage | |
| 650 | 4 | |a Point-of-care testing | |
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| 700 | 1 | |a Yamamoto, Takamasa |e verfasserin |4 aut | |
| 700 | 1 | |a Misawa, Shigeki |e verfasserin |4 aut | |
| 700 | 1 | |a Miida, Takashi |e verfasserin |4 aut | |
| 700 | 1 | |a Sumikura, Hiroyuki |e verfasserin |4 aut | |
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