Antibiotic prophylaxis for transrectal prostate biopsy : In the context of restricted indications for fluoroquinolones and antibiotic stewardship
© 2021. The Author(s)..
BACKGROUND: Transrectal prostate biopsy (TRPB) is the gold standard for prostate cancer diagnosis and among the most common urological interventions. Short-term antibiotic prophylaxis (PAP) is recommended for TRPB. Fluoroquinolone-PAP as standard of care needs to be revaluated due to the restrictions on the use of fluoroquinolone antibiotics by the German Federal Institute for Drugs and Medical Devices.
OBJECTIVES: The aim of the study was to analyze clinical practice of PAP for TRPB with focus on infectious complications and potential differences between fluoroquinolone-PAP and cotrimoxazole-PAP.
METHODS: We performed a retrospective monocentric study of clinical and microbiological characteristics of patients with TRPB between 3 January 2019 and 28 January 2021.
RESULTS: A total of 508 men were included; median age was 68 years. In all, 55.9% of our cohort received cotrimoxazole-PAP and 40.0% fluoroquinolone-PAP. Postinterventional complications occurred in 5.5%, of those 50.0% were infectious complications. Complication rate did not differ between patients with fluoroquinolone-PAP and cotrimoxazole-PAP. Urinary cultures in case of postinterventional complications yielded pathogens with antimicrobial resistance against the used PAP substance indicating selection of resistant bacteria.
CONCLUSION: Cotrimoxazole-PAP for TRPB is not associated with an increase of infectious complications compared to fluoroquinolone-PAP. Cultures obtained prior to TRPB to identify antimicrobial resistance facilitate targeted PAP and therefore can reduce complications.
Medienart: |
E-Artikel |
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Erscheinungsjahr: |
2022 |
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Erschienen: |
2022 |
Enthalten in: |
Zur Gesamtaufnahme - volume:61 |
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Enthalten in: |
Der Urologe. Ausg. A - 61(2022), 2 vom: 18. Feb., Seite 160-166 |
Sprache: |
Deutsch |
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Weiterer Titel: |
Antibiotikaprophylaxe bei transrektaler Prostatabiopsie : Im Kontext von Fluorchinolon-Indikationsrücknahme und Antibiotic Stewardship |
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Beteiligte Personen: |
Rothe, Kathrin [VerfasserIn] |
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Links: |
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Themen: |
Anti-Bacterial Agents |
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Anmerkungen: |
Date Completed 14.02.2022 Date Revised 01.06.2022 published: Print-Electronic Citation Status MEDLINE |
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doi: |
10.1007/s00120-021-01618-1 |
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funding: |
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Förderinstitution / Projekttitel: |
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PPN (Katalog-ID): |
NLM329529803 |
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520 | |a © 2021. The Author(s). | ||
520 | |a BACKGROUND: Transrectal prostate biopsy (TRPB) is the gold standard for prostate cancer diagnosis and among the most common urological interventions. Short-term antibiotic prophylaxis (PAP) is recommended for TRPB. Fluoroquinolone-PAP as standard of care needs to be revaluated due to the restrictions on the use of fluoroquinolone antibiotics by the German Federal Institute for Drugs and Medical Devices | ||
520 | |a OBJECTIVES: The aim of the study was to analyze clinical practice of PAP for TRPB with focus on infectious complications and potential differences between fluoroquinolone-PAP and cotrimoxazole-PAP | ||
520 | |a METHODS: We performed a retrospective monocentric study of clinical and microbiological characteristics of patients with TRPB between 3 January 2019 and 28 January 2021 | ||
520 | |a RESULTS: A total of 508 men were included; median age was 68 years. In all, 55.9% of our cohort received cotrimoxazole-PAP and 40.0% fluoroquinolone-PAP. Postinterventional complications occurred in 5.5%, of those 50.0% were infectious complications. Complication rate did not differ between patients with fluoroquinolone-PAP and cotrimoxazole-PAP. Urinary cultures in case of postinterventional complications yielded pathogens with antimicrobial resistance against the used PAP substance indicating selection of resistant bacteria | ||
520 | |a CONCLUSION: Cotrimoxazole-PAP for TRPB is not associated with an increase of infectious complications compared to fluoroquinolone-PAP. Cultures obtained prior to TRPB to identify antimicrobial resistance facilitate targeted PAP and therefore can reduce complications | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Antimicrobial resistance | |
650 | 4 | |a Clinical practice of PAP | |
650 | 4 | |a Fluoroquinolone-PAP | |
650 | 4 | |a Infectious complications | |
650 | 4 | |a Targeted PAPs | |
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700 | 1 | |a Busch, Dirk H |e verfasserin |4 aut | |
700 | 1 | |a Gschwend, Jürgen E |e verfasserin |4 aut | |
700 | 1 | |a Hauner, Katharina |e verfasserin |4 aut | |
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