Vibegron : a β3-adrenergic agonist for the treatment of overactive bladder
Copyright 2021 Clarivate Analytics..
Overactive bladder (OAB) is an extremely common condition in adults of both sexes. It is characterized by an urgent need to micturate often accompanied by incontinence. The condition may also increase the number of micturitions in a 24-hour period as well as nocturia. The syndrome is not due to a urinary infection or other obvious pathology. In terms of drug treatment of OAB, there are two main approaches. One is the use of anticholinergic drugs that reduce the effect of the parasympathetic nervous system on the bladder. The other involves the use of drugs that are agonists at β3-adrenergic receptors in the bladder. These drugs increase the capacity of the bladder and cause reductions in the number of daily micturitions and nocturia and also importantly reduce the frequency of urinary urgency and urinary urgency incontinence. Vibegron is the second β3-adrenergic agonist to be approved for the treatment of OAB.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2021 |
---|---|
Erschienen: |
2021 |
Enthalten in: |
Zur Gesamtaufnahme - volume:57 |
---|---|
Enthalten in: |
Drugs of today (Barcelona, Spain : 1998) - 57(2021), 8 vom: 13. Aug., Seite 507-517 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Paton, D M [VerfasserIn] |
---|
Links: |
---|
Anmerkungen: |
Date Completed 19.08.2021 Date Revised 19.08.2021 published: Print Citation Status MEDLINE |
---|
doi: |
10.1358/dot.2021.57.8.3293588 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM329487841 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM329487841 | ||
003 | DE-627 | ||
005 | 20231225205227.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231225s2021 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1358/dot.2021.57.8.3293588 |2 doi | |
028 | 5 | 2 | |a pubmed24n1098.xml |
035 | |a (DE-627)NLM329487841 | ||
035 | |a (NLM)34405208 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Paton, D M |e verfasserin |4 aut | |
245 | 1 | 0 | |a Vibegron |b a β3-adrenergic agonist for the treatment of overactive bladder |
264 | 1 | |c 2021 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 19.08.2021 | ||
500 | |a Date Revised 19.08.2021 | ||
500 | |a published: Print | ||
500 | |a Citation Status MEDLINE | ||
520 | |a Copyright 2021 Clarivate Analytics. | ||
520 | |a Overactive bladder (OAB) is an extremely common condition in adults of both sexes. It is characterized by an urgent need to micturate often accompanied by incontinence. The condition may also increase the number of micturitions in a 24-hour period as well as nocturia. The syndrome is not due to a urinary infection or other obvious pathology. In terms of drug treatment of OAB, there are two main approaches. One is the use of anticholinergic drugs that reduce the effect of the parasympathetic nervous system on the bladder. The other involves the use of drugs that are agonists at β3-adrenergic receptors in the bladder. These drugs increase the capacity of the bladder and cause reductions in the number of daily micturitions and nocturia and also importantly reduce the frequency of urinary urgency and urinary urgency incontinence. Vibegron is the second β3-adrenergic agonist to be approved for the treatment of OAB | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Genitourinary disorders | |
650 | 4 | |a Overactive bladder | |
650 | 4 | |a Renal-urologic drugs | |
650 | 4 | |a Vibegron | |
650 | 4 | |a β | |
650 | 7 | |a Acetanilides |2 NLM | |
650 | 7 | |a Adrenergic Agonists |2 NLM | |
650 | 7 | |a Adrenergic beta-3 Receptor Agonists |2 NLM | |
650 | 7 | |a N-(4-((5-(hydroxy(phenyl)methyl)pyrrolidin-2-yl)methyl)phenyl)-4-oxo-4,6,7,8-tetrahydropyrrolo(1,2-a)pyrimidine-6-carboxamide |2 NLM | |
650 | 7 | |a Pyrimidinones |2 NLM | |
650 | 7 | |a Pyrrolidines |2 NLM | |
773 | 0 | 8 | |i Enthalten in |t Drugs of today (Barcelona, Spain : 1998) |d 1998 |g 57(2021), 8 vom: 13. Aug., Seite 507-517 |w (DE-627)NLM123139600 |x 1699-3993 |7 nnns |
773 | 1 | 8 | |g volume:57 |g year:2021 |g number:8 |g day:13 |g month:08 |g pages:507-517 |
856 | 4 | 0 | |u http://dx.doi.org/10.1358/dot.2021.57.8.3293588 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 57 |j 2021 |e 8 |b 13 |c 08 |h 507-517 |