Atoltivimab/maftivimab/odesivimab (Inmazeb) combination to treat infection caused by Zaire ebolavirus
Copyright 2021 Clarivate Analytics..
Zaire ebolavirus has been responsible for several catastrophic outbreaks with a high mortality rate. Unfortunately, there were no approved therapies or vaccines to treat or prevent infections caused by Ebola virus (EBOV) or other filoviruses. Atoltivimab/ maftivimab/odesivimab (Inmazeb) is the first Food and Drug Administration (FDA)-approved treatment for Zaire ebolavirus infection in adult and pediatric patients, including neonates born to a mother who is reverse transcription polymerase chain reaction (RT-PCR)-positive for Zaire ebolavirus infection. The efficacy of Inmazeb has been established in vivo and it has successfully completed a phase I clinical trial in healthy individuals with no drug-related adverse effects. Additionally, Inmazeb has displayed significant reduction in mortality in the PALM (PAmoja tuLinde Maisha) trial, when compared with the control arm receiving ZMapp. Inmazeb has received orphan drug designation from both the U.S. FDA and the European Medicines Agency (EMA).
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:57 |
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| Enthalten in: |
Drugs of today (Barcelona, Spain : 1998) - 57(2021), 8 vom: 13. Aug., Seite 483-490 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Saxena, D [VerfasserIn] |
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| Links: |
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| Themen: |
Antiviral drugs |
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| Anmerkungen: |
Date Completed 19.08.2021 Date Revised 19.08.2021 published: Print Citation Status MEDLINE |
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| doi: |
10.1358/dot.2021.57.8.3280599 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM329487817 |
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| 520 | |a Copyright 2021 Clarivate Analytics. | ||
| 520 | |a Zaire ebolavirus has been responsible for several catastrophic outbreaks with a high mortality rate. Unfortunately, there were no approved therapies or vaccines to treat or prevent infections caused by Ebola virus (EBOV) or other filoviruses. Atoltivimab/ maftivimab/odesivimab (Inmazeb) is the first Food and Drug Administration (FDA)-approved treatment for Zaire ebolavirus infection in adult and pediatric patients, including neonates born to a mother who is reverse transcription polymerase chain reaction (RT-PCR)-positive for Zaire ebolavirus infection. The efficacy of Inmazeb has been established in vivo and it has successfully completed a phase I clinical trial in healthy individuals with no drug-related adverse effects. Additionally, Inmazeb has displayed significant reduction in mortality in the PALM (PAmoja tuLinde Maisha) trial, when compared with the control arm receiving ZMapp. Inmazeb has received orphan drug designation from both the U.S. FDA and the European Medicines Agency (EMA) | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Antiviral drugs | |
| 650 | 4 | |a Atoltivimab | |
| 650 | 4 | |a Combination therapy | |
| 650 | 4 | |a Drugs targeting Zaire ebolavirus glycoprotein | |
| 650 | 4 | |a Ebola virus disease | |
| 650 | 4 | |a Inmazeb | |
| 650 | 4 | |a Maftivimab | |
| 650 | 4 | |a Monoclonal antibodies | |
| 650 | 4 | |a Odesivimab | |
| 700 | 1 | |a Kaul, G |e verfasserin |4 aut | |
| 700 | 1 | |a Dasgupta, A |e verfasserin |4 aut | |
| 700 | 1 | |a Chopra, S |e verfasserin |4 aut | |
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