Thalamocortical Mechanisms Regulating the Relationship between Transient Beta Events and Human Tactile Perception
© The Author(s) 2021. Published by Oxford University Press..
Transient neocortical events with high spectral power in the 15-29 Hz beta band are among the most reliable predictors of sensory perception. Prestimulus beta event rates in primary somatosensory cortex correlate with sensory suppression, most effectively 100-300 ms before stimulus onset. However, the neural mechanisms underlying this perceptual association are unknown. We combined human magnetoencephalography (MEG) measurements with biophysical neural modeling to test potential cellular and circuit mechanisms that underlie observed correlations between prestimulus beta events and tactile detection. Extending prior studies, we found that simulated bursts from higher-order, nonlemniscal thalamus were sufficient to drive beta event generation and to recruit slow supragranular inhibition acting on a 300 ms timescale to suppress sensory information. Further analysis showed that the same beta-generating mechanism can lead to facilitated perception for a brief period when beta events occur simultaneously with tactile stimulation before inhibition is recruited. These findings were supported by close agreement between model-derived predictions and empirical MEG data. The postevent suppressive mechanism explains an array of studies that associate beta with decreased processing, whereas the during-event facilitatory mechanism may demand a reinterpretation of the role of beta events in the context of coincident timing.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:32 |
|---|---|
| Enthalten in: |
Cerebral cortex (New York, N.Y. : 1991) - 32(2022), 4 vom: 08. Feb., Seite 668-688 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Law, Robert G [VerfasserIn] |
|---|
| Links: |
|---|
| Anmerkungen: |
Date Completed 31.03.2022 Date Revised 19.05.2022 published: Print Citation Status MEDLINE |
|---|
| doi: |
10.1093/cercor/bhab221 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM329455257 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM329455257 | ||
| 003 | DE-627 | ||
| 005 | 20231225205146.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1093/cercor/bhab221 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1098.xml |
| 035 | |a (DE-627)NLM329455257 | ||
| 035 | |a (NLM)34401898 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Law, Robert G |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Thalamocortical Mechanisms Regulating the Relationship between Transient Beta Events and Human Tactile Perception |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 31.03.2022 | ||
| 500 | |a Date Revised 19.05.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © The Author(s) 2021. Published by Oxford University Press. | ||
| 520 | |a Transient neocortical events with high spectral power in the 15-29 Hz beta band are among the most reliable predictors of sensory perception. Prestimulus beta event rates in primary somatosensory cortex correlate with sensory suppression, most effectively 100-300 ms before stimulus onset. However, the neural mechanisms underlying this perceptual association are unknown. We combined human magnetoencephalography (MEG) measurements with biophysical neural modeling to test potential cellular and circuit mechanisms that underlie observed correlations between prestimulus beta events and tactile detection. Extending prior studies, we found that simulated bursts from higher-order, nonlemniscal thalamus were sufficient to drive beta event generation and to recruit slow supragranular inhibition acting on a 300 ms timescale to suppress sensory information. Further analysis showed that the same beta-generating mechanism can lead to facilitated perception for a brief period when beta events occur simultaneously with tactile stimulation before inhibition is recruited. These findings were supported by close agreement between model-derived predictions and empirical MEG data. The postevent suppressive mechanism explains an array of studies that associate beta with decreased processing, whereas the during-event facilitatory mechanism may demand a reinterpretation of the role of beta events in the context of coincident timing | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Research Support, U.S. Gov't, Non-P.H.S. | |
| 650 | 4 | |a beta rhythm | |
| 650 | 4 | |a event-related potential | |
| 650 | 4 | |a magnetoencephalography | |
| 650 | 4 | |a neural modeling | |
| 650 | 4 | |a tactile detection | |
| 700 | 1 | |a Pugliese, Sarah |e verfasserin |4 aut | |
| 700 | 1 | |a Shin, Hyeyoung |e verfasserin |4 aut | |
| 700 | 1 | |a Sliva, Danielle D |e verfasserin |4 aut | |
| 700 | 1 | |a Lee, Shane |e verfasserin |4 aut | |
| 700 | 1 | |a Neymotin, Samuel |e verfasserin |4 aut | |
| 700 | 1 | |a Moore, Christopher |e verfasserin |4 aut | |
| 700 | 1 | |a Jones, Stephanie R |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Cerebral cortex (New York, N.Y. : 1991) |d 1997 |g 32(2022), 4 vom: 08. Feb., Seite 668-688 |w (DE-627)NLM012627887 |x 1460-2199 |7 nnns |
| 773 | 1 | 8 | |g volume:32 |g year:2022 |g number:4 |g day:08 |g month:02 |g pages:668-688 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1093/cercor/bhab221 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 32 |j 2022 |e 4 |b 08 |c 02 |h 668-688 | ||