Preserved Mucosal-Associated Invariant T-Cell Numbers and Function in Idiopathic CD4 Lymphocytopenia
Published by Oxford University Press for the Infectious Diseases Society of America 2020..
BACKGROUND: Mucosal-associated invariant T (MAIT) cells constitute a subset of unconventional, MR1-restricted T cells involved in antimicrobial responses as well as inflammatory, allergic, and autoimmune diseases. Chronic infection and inflammatory disorders as well as immunodeficiencies are often associated with decline and/or dysfunction of MAIT cells.
METHODS: We investigated the MAIT cells in patients with idiopathic CD4+ lymphocytopenia (ICL), a syndrome characterized by consistently low CD4 T-cell counts (<300 cell/µL) in the absence of HIV infection or other known immunodeficiency, and by susceptibility to certain opportunistic infections.
RESULTS: The numbers, phenotype, and function of MAIT cells in peripheral blood were preserved in ICL patients compared to healthy controls. Administration of interleukin-7 (IL-7) to ICL patients expanded the CD8+ MAIT-cell subset, with maintained responsiveness and effector functions after IL-7 treatment.
CONCLUSIONS: ICL patients maintain normal levels and function of MAIT cells, preserving some antibacterial responses despite the deficiency in CD4+ T cells.
CLINICAL TRIALS REGISTRATION: NCT00867269.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:224 |
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| Enthalten in: |
The Journal of infectious diseases - 224(2021), 4 vom: 16. Aug., Seite 715-725 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Sortino, Ornella [VerfasserIn] |
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| Links: |
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| Themen: |
IL-7 |
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| Anmerkungen: |
Date Completed 01.02.2022 Date Revised 01.02.2022 published: Print ClinicalTrials.gov: NCT00867269 Citation Status MEDLINE |
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| doi: |
10.1093/infdis/jiaa782 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM329419056 |
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| 500 | |a Date Completed 01.02.2022 | ||
| 500 | |a Date Revised 01.02.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a ClinicalTrials.gov: NCT00867269 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Published by Oxford University Press for the Infectious Diseases Society of America 2020. | ||
| 520 | |a BACKGROUND: Mucosal-associated invariant T (MAIT) cells constitute a subset of unconventional, MR1-restricted T cells involved in antimicrobial responses as well as inflammatory, allergic, and autoimmune diseases. Chronic infection and inflammatory disorders as well as immunodeficiencies are often associated with decline and/or dysfunction of MAIT cells | ||
| 520 | |a METHODS: We investigated the MAIT cells in patients with idiopathic CD4+ lymphocytopenia (ICL), a syndrome characterized by consistently low CD4 T-cell counts (<300 cell/µL) in the absence of HIV infection or other known immunodeficiency, and by susceptibility to certain opportunistic infections | ||
| 520 | |a RESULTS: The numbers, phenotype, and function of MAIT cells in peripheral blood were preserved in ICL patients compared to healthy controls. Administration of interleukin-7 (IL-7) to ICL patients expanded the CD8+ MAIT-cell subset, with maintained responsiveness and effector functions after IL-7 treatment | ||
| 520 | |a CONCLUSIONS: ICL patients maintain normal levels and function of MAIT cells, preserving some antibacterial responses despite the deficiency in CD4+ T cells | ||
| 520 | |a CLINICAL TRIALS REGISTRATION: NCT00867269 | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Observational Study | |
| 650 | 4 | |a Research Support, N.I.H., Extramural | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a IL-7 | |
| 650 | 4 | |a MAIT cells | |
| 650 | 4 | |a idiopathic CD4+ lymphocytopenia | |
| 650 | 7 | |a Interleukin-7 |2 NLM | |
| 700 | 1 | |a Dias, Joana |e verfasserin |4 aut | |
| 700 | 1 | |a Anderson, Megan |e verfasserin |4 aut | |
| 700 | 1 | |a Laidlaw, Elizabeth |e verfasserin |4 aut | |
| 700 | 1 | |a Leeansyah, Edwin |e verfasserin |4 aut | |
| 700 | 1 | |a Lisco, Andrea |e verfasserin |4 aut | |
| 700 | 1 | |a Sheikh, Virginia |e verfasserin |4 aut | |
| 700 | 1 | |a Sandberg, Johan K |e verfasserin |4 aut | |
| 700 | 1 | |a Sereti, Irini |e verfasserin |4 aut | |
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