Oral Angiotensin-(1-7) Peptide Modulates Intestinal Microbiota Improving Metabolic Profile in Obese Mice
Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net..
BACKGROUND: Obesity is a serious health problem that dysregulate Renin-Angiotensin System (RAS) and intestinal microbiota.
OBJECTIVE: The present study aimed to evaluate the Angiotensin-(1-7) [ANG-(1-7)] oral formulation effects on obese mice intestinal microbiota.
METHODS: Mice were divided into four groups: obese and non-obese treated with ANG-(1-7) and obese and non-obese without ANG-(1-7) during four weeks.
RESULTS: We observed a significant decrease in the fasting plasma glucose, total cholesterol, triglycerides, and Low-density lipoprotein levels and increased High-density lipoprotein in animals treated with ANG-(1-7). The histological analysis showed intestinal villi height reduction in mice treated with ANG-(1-7). Additionally, increased Bacteroidetes and decreased Firmicutes (increased Bacteroidetes/ Firmicutes ratio) and Enterobacter cloacae populations were observed in the High-Fat Diet + ANG-(1-7) group. Receptor toll-like 4 (TLR4) intestinal mRNA expression was reduced in the HFD+ANG-(1-7) group. Finally, the intestinal expression of the neutral amino acid transporter (B0AT1) was increased in animals treated with ANG-(1-7), indicating a possible mechanism associated with tryptophan uptake.
CONCLUSION: The results of the present study suggest for the first time an interaction between oral ANG-(1-7) and intestinal microbiota modulation.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:28 |
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| Enthalten in: |
Protein and peptide letters - 28(2021), 10 vom: 16., Seite 1127-1137 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Machado, Amanda [VerfasserIn] |
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| Links: |
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| Anmerkungen: |
Date Completed 31.01.2022 Date Revised 31.01.2022 published: Print Citation Status MEDLINE |
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| doi: |
10.2174/0929866528666210816115645 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM329410377 |
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| 500 | |a Date Revised 31.01.2022 | ||
| 500 | |a published: Print | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright© Bentham Science Publishers; For any queries, please email at epubbenthamscience.net. | ||
| 520 | |a BACKGROUND: Obesity is a serious health problem that dysregulate Renin-Angiotensin System (RAS) and intestinal microbiota | ||
| 520 | |a OBJECTIVE: The present study aimed to evaluate the Angiotensin-(1-7) [ANG-(1-7)] oral formulation effects on obese mice intestinal microbiota | ||
| 520 | |a METHODS: Mice were divided into four groups: obese and non-obese treated with ANG-(1-7) and obese and non-obese without ANG-(1-7) during four weeks | ||
| 520 | |a RESULTS: We observed a significant decrease in the fasting plasma glucose, total cholesterol, triglycerides, and Low-density lipoprotein levels and increased High-density lipoprotein in animals treated with ANG-(1-7). The histological analysis showed intestinal villi height reduction in mice treated with ANG-(1-7). Additionally, increased Bacteroidetes and decreased Firmicutes (increased Bacteroidetes/ Firmicutes ratio) and Enterobacter cloacae populations were observed in the High-Fat Diet + ANG-(1-7) group. Receptor toll-like 4 (TLR4) intestinal mRNA expression was reduced in the HFD+ANG-(1-7) group. Finally, the intestinal expression of the neutral amino acid transporter (B0AT1) was increased in animals treated with ANG-(1-7), indicating a possible mechanism associated with tryptophan uptake | ||
| 520 | |a CONCLUSION: The results of the present study suggest for the first time an interaction between oral ANG-(1-7) and intestinal microbiota modulation | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a ACE2. | |
| 650 | 4 | |a Gut microbiota | |
| 650 | 4 | |a metabolic endotoxemia | |
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| 700 | 1 | |a Guimarães, Andre L S |e verfasserin |4 aut | |
| 700 | 1 | |a Brandi, Igor V |e verfasserin |4 aut | |
| 700 | 1 | |a de Carvalho, Bruna Mara A |e verfasserin |4 aut | |
| 700 | 1 | |a da Costa, Diego Vicente |e verfasserin |4 aut | |
| 700 | 1 | |a Vieira, Cláudia Regina |e verfasserin |4 aut | |
| 700 | 1 | |a Pereira, Ulisses Alves |e verfasserin |4 aut | |
| 700 | 1 | |a de Oliveira Costa, Theles |e verfasserin |4 aut | |
| 700 | 1 | |a Andrade, João M O |e verfasserin |4 aut | |
| 700 | 1 | |a Santos, Robson Augusto Souza |e verfasserin |4 aut | |
| 700 | 1 | |a Santos, Sérgio H S |e verfasserin |4 aut | |
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