Association between semiologic, autonomic, and electrographic seizure characteristics in children with generalized tonic-clonic seizures
Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved..
INTRODUCTION: Generalized tonic-clonic seizures (GTCS) are associated with elevated electrodermal activity (EDA) and postictal generalized electroencephalographic suppression (PGES), markers that may indicate sudden unexpected death in epilepsy (SUDEP) risk. This study investigated the association of GTCS semiology, EDA, and PGES in children with epilepsy.
METHODS: Patients admitted to the Boston Children's Hospital long-term video-EEG monitoring unit wore a sensor that records EDA. We selected patients with at least one GTCS and reviewed video-EEGs for semiology, tonic and clonic phase duration, total clinical seizure duration, electrographic onset, offset, and PGES. We grouped patients into three semiology classes: GTCS 1: bilateral symmetric tonic arm extension, GTCS 2: no specific tonic arm extension or flexion, GTCS 3: unilateral or asymmetrical arm extension, tonic arm flexion or posturing that does not fit into GTCS 1 or 2. We analyzed the correlation between semiology, EDA, and PGES, and measured the area under the curve (AUC) of the ictal EDA (seizure onset to one hour after), subtracting baseline EDA (one-hour seizure-free before seizure onset). Using generalized estimating equation (GEE) and linear regression, we analyzed all seizures and single episodes per patient.
RESULTS: We included 30 patients (median age 13.8 ± 3.6 years, 46.7% females) and 53 seizures. With GEE, GTCS 1 was associated with longer PGES duration compared to GTCS 2 (Estimate (β) = -26.32 s, 95% Confidence Interval (CI): -36.46 to -16.18, p < 0.001), and the presence of PGES was associated with greater EDA change (β = 429604 μS, 95% CI: 3550.96 to 855657.04, p = 0.048). With single-episode analysis, GTCS 1 had greater EDA change than GTCS 2 ((β = -601339 μS, 95% CI: -1167016.56 to -35661.44, p = 0.047). EDA increased with PGES presence (β = 637500 μS, 95% CI: 183571.84 to 1091428.16, p = 0.01) and duration (β = 16794 μS, 95% CI: 5729.8 to 27858.2, p = 0.006). Patients with GTCS 1 had longer PGES duration compared to GTCS 2 (β = -30.53 s, 95% CI: -44.6 to -16.46, p < 0.001) and GTCS 3 (β = -22.07 s, 95% CI: -38.95 to -5.19, p = 0.016).
CONCLUSION: In children with epilepsy, PGES correlates with greater ictal EDA. GTCS 1 correlated with longer PGES duration and may indirectly correlate with greater ictal EDA. Our study suggests potential applications in monitoring and preventing SUDEP in these patients.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:122 |
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| Enthalten in: |
Epilepsy & behavior : E&B - 122(2021) vom: 13. Sept., Seite 108228 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
El Atrache, Rima [VerfasserIn] |
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| Links: |
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| Themen: |
Epilepsy |
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| Anmerkungen: |
Date Completed 15.09.2021 Date Revised 15.09.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.yebeh.2021.108228 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM329324373 |
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| 245 | 1 | 0 | |a Association between semiologic, autonomic, and electrographic seizure characteristics in children with generalized tonic-clonic seizures |
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| 500 | |a published: Print-Electronic | ||
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| 520 | |a Copyright © 2021 The Authors. Published by Elsevier Inc. All rights reserved. | ||
| 520 | |a INTRODUCTION: Generalized tonic-clonic seizures (GTCS) are associated with elevated electrodermal activity (EDA) and postictal generalized electroencephalographic suppression (PGES), markers that may indicate sudden unexpected death in epilepsy (SUDEP) risk. This study investigated the association of GTCS semiology, EDA, and PGES in children with epilepsy | ||
| 520 | |a METHODS: Patients admitted to the Boston Children's Hospital long-term video-EEG monitoring unit wore a sensor that records EDA. We selected patients with at least one GTCS and reviewed video-EEGs for semiology, tonic and clonic phase duration, total clinical seizure duration, electrographic onset, offset, and PGES. We grouped patients into three semiology classes: GTCS 1: bilateral symmetric tonic arm extension, GTCS 2: no specific tonic arm extension or flexion, GTCS 3: unilateral or asymmetrical arm extension, tonic arm flexion or posturing that does not fit into GTCS 1 or 2. We analyzed the correlation between semiology, EDA, and PGES, and measured the area under the curve (AUC) of the ictal EDA (seizure onset to one hour after), subtracting baseline EDA (one-hour seizure-free before seizure onset). Using generalized estimating equation (GEE) and linear regression, we analyzed all seizures and single episodes per patient | ||
| 520 | |a RESULTS: We included 30 patients (median age 13.8 ± 3.6 years, 46.7% females) and 53 seizures. With GEE, GTCS 1 was associated with longer PGES duration compared to GTCS 2 (Estimate (β) = -26.32 s, 95% Confidence Interval (CI): -36.46 to -16.18, p < 0.001), and the presence of PGES was associated with greater EDA change (β = 429604 μS, 95% CI: 3550.96 to 855657.04, p = 0.048). With single-episode analysis, GTCS 1 had greater EDA change than GTCS 2 ((β = -601339 μS, 95% CI: -1167016.56 to -35661.44, p = 0.047). EDA increased with PGES presence (β = 637500 μS, 95% CI: 183571.84 to 1091428.16, p = 0.01) and duration (β = 16794 μS, 95% CI: 5729.8 to 27858.2, p = 0.006). Patients with GTCS 1 had longer PGES duration compared to GTCS 2 (β = -30.53 s, 95% CI: -44.6 to -16.46, p < 0.001) and GTCS 3 (β = -22.07 s, 95% CI: -38.95 to -5.19, p = 0.016) | ||
| 520 | |a CONCLUSION: In children with epilepsy, PGES correlates with greater ictal EDA. GTCS 1 correlated with longer PGES duration and may indirectly correlate with greater ictal EDA. Our study suggests potential applications in monitoring and preventing SUDEP in these patients | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Research Support, Non-U.S. Gov't | |
| 650 | 4 | |a Epilepsy | |
| 650 | 4 | |a GTCS | |
| 650 | 4 | |a PGES | |
| 650 | 4 | |a SUDEP | |
| 650 | 4 | |a Semiology | |
| 700 | 1 | |a Tamilia, Eleonora |e verfasserin |4 aut | |
| 700 | 1 | |a Amengual-Gual, Marta |e verfasserin |4 aut | |
| 700 | 1 | |a Mohammadpour Touserkani, Fatemeh |e verfasserin |4 aut | |
| 700 | 1 | |a Yang, Yonghua |e verfasserin |4 aut | |
| 700 | 1 | |a Wang, Xiaofan |e verfasserin |4 aut | |
| 700 | 1 | |a Ufongene, Claire |e verfasserin |4 aut | |
| 700 | 1 | |a Sheehan, Theodore |e verfasserin |4 aut | |
| 700 | 1 | |a Cantley, Sarah |e verfasserin |4 aut | |
| 700 | 1 | |a Jackson, Michele |e verfasserin |4 aut | |
| 700 | 1 | |a Zhang, Bo |e verfasserin |4 aut | |
| 700 | 1 | |a Papadelis, Christos |e verfasserin |4 aut | |
| 700 | 1 | |a Sarkis, Rani A |e verfasserin |4 aut | |
| 700 | 1 | |a Loddenkemper, Tobias |e verfasserin |4 aut | |
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