Evaluation of serum neutrophil-to-lymphocyte ratio in corneal graft rejection after low-risk penetrating keratoplasty
© 2021. The Author(s), under exclusive licence to Springer Nature B.V..
PURPOSE: To evaluate systemic inflammatory parameters in patients with corneal graft rejection after low-risk penetrating keratoplasty.
METHODS: Patients undergoing penetrating keratoplasty with indications of keratoconus, pseudophakic bullous keratopathy, and Fuchs endothelial dystrophy were analyzed retrospectively. Patients who had an endothelial rejection attack within two years post-transplant were included in the rejection group (n = 20), whereas patients with at least two years of post-transplant follow-up without graft rejection or failure were included in the control group (n = 46). All patients' clinical features and preoperative laboratory parameters were obtained from hospital records. The neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio, and platelet-to-lymphocyte ratio of the groups were calculated and compared.
RESULTS: There was no difference between the two groups in terms of age, sex, indication, postmortem time and storage time of grafts, graft diameter, follow-up time, and common systemic diseases (p > 0.05). The NLR was found to be significantly lower in the rejection group when compared with the control group (2.04 ± 1.17, 2.66 ± 0.91, respectively, p = 0.023). There was no significant difference between the groups in terms of MLR and PLR (p = 0.243, p = 0.101, respectively).
CONCLUSIONS: Although a high NLR value, which is an indicator of systemic inflammatory condition, is associated with many ocular diseases, NLR was found to be lower in patients with a rejection episode after transplant surgery when compared with the control group. Further studies are needed to clarify the role of these hematologic parameters in graft rejection.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:42 |
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| Enthalten in: |
International ophthalmology - 42(2022), 1 vom: 13. Jan., Seite 57-63 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Yıldız, Merve Beyza [VerfasserIn] |
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| Links: |
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| Themen: |
Graft rejection |
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| Anmerkungen: |
Date Completed 02.02.2022 Date Revised 02.02.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s10792-021-01999-4 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM329315617 |
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| 520 | |a © 2021. The Author(s), under exclusive licence to Springer Nature B.V. | ||
| 520 | |a PURPOSE: To evaluate systemic inflammatory parameters in patients with corneal graft rejection after low-risk penetrating keratoplasty | ||
| 520 | |a METHODS: Patients undergoing penetrating keratoplasty with indications of keratoconus, pseudophakic bullous keratopathy, and Fuchs endothelial dystrophy were analyzed retrospectively. Patients who had an endothelial rejection attack within two years post-transplant were included in the rejection group (n = 20), whereas patients with at least two years of post-transplant follow-up without graft rejection or failure were included in the control group (n = 46). All patients' clinical features and preoperative laboratory parameters were obtained from hospital records. The neutrophil-to-lymphocyte ratio (NLR), monocyte-to-lymphocyte ratio, and platelet-to-lymphocyte ratio of the groups were calculated and compared | ||
| 520 | |a RESULTS: There was no difference between the two groups in terms of age, sex, indication, postmortem time and storage time of grafts, graft diameter, follow-up time, and common systemic diseases (p > 0.05). The NLR was found to be significantly lower in the rejection group when compared with the control group (2.04 ± 1.17, 2.66 ± 0.91, respectively, p = 0.023). There was no significant difference between the groups in terms of MLR and PLR (p = 0.243, p = 0.101, respectively) | ||
| 520 | |a CONCLUSIONS: Although a high NLR value, which is an indicator of systemic inflammatory condition, is associated with many ocular diseases, NLR was found to be lower in patients with a rejection episode after transplant surgery when compared with the control group. Further studies are needed to clarify the role of these hematologic parameters in graft rejection | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Graft rejection | |
| 650 | 4 | |a Monocyte-to-Lymphocyte Ratio (MLR) | |
| 650 | 4 | |a Neutrophil-to-Lymphocyte Ratio (NLR) | |
| 650 | 4 | |a Penetrating keratoplasty | |
| 650 | 4 | |a Platelet-to-Lymphocyte Ratio (PLR) | |
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