Dopamine receptors in the anterior cingulate cortex implicate in nicotine enhanced morphine analgesia
© 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature..
RATIONALE: It is well known that the anterior cingulate cortex (ACC) plays an important role in acute pain perception.
OBJECTIVES: In the present study, we aimed to investigate the possible involvement of the ACC dopamine D1 and D2 receptors in nicotine plus morphine-induced analgesia.
METHODS: The ACC's of adult male Wistar rats were bilaterally cannulated by stereotaxic instrument and the tail-flick test was used to measure the thermal pain threshold.
RESULTS: The results indicated that subcutaneous (s.c.) injection of nicotine (0.3 mg/kg) potentiated the analgesic response of intraperitoneal (i.p.) administration of morphine (3 mg/kg). Systemic administration of the same doses of nicotine or morphine alone had no effect on tail-flick latency. Intra-ACC administration of apomorphine (0.3-0.9 μg/rat), the non-selective D1/D2 receptors agonist, plus ineffective doses of nicotine (0.1 mg/kg, s.c.) plus morphine (3 mg/kg, i.p) induced analgesia in rats. In addition, the analgesia induced with co-administration of nicotine and morphine was inhibited via intra-ACC administration of SCH23390 (0.5-1 μg/rat) or sulpiride (0.5-2 μg/rat), the selective antagonists of D1 or D2 receptors, respectively. The intra-ACC microinjection of the same doses of drugs alone had no effect on tail-flick latency. Cubic interpolation analysis also confirmed that activation or inactivation of the ACC D1 and D2 receptors by different doses of drugs can modulate the nicotine-morphine analgesic response.
CONCLUSIONS: The findings suggest that the ACC has an important role in acute thermal pain perception and modulates the analgesia induced by nicotine plus morphine via dopaminergic receptors.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:238 |
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| Enthalten in: |
Psychopharmacology - 238(2021), 11 vom: 19. Nov., Seite 3311-3323 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Sardari, Maryam [VerfasserIn] |
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| Links: |
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| Themen: |
6M3C89ZY6R |
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| Anmerkungen: |
Date Completed 23.11.2021 Date Revised 23.11.2021 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1007/s00213-021-05947-z |
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| funding: |
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| Förderinstitution / Projekttitel: |
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NLM329269658 |
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| 520 | |a © 2021. The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. | ||
| 520 | |a RATIONALE: It is well known that the anterior cingulate cortex (ACC) plays an important role in acute pain perception | ||
| 520 | |a OBJECTIVES: In the present study, we aimed to investigate the possible involvement of the ACC dopamine D1 and D2 receptors in nicotine plus morphine-induced analgesia | ||
| 520 | |a METHODS: The ACC's of adult male Wistar rats were bilaterally cannulated by stereotaxic instrument and the tail-flick test was used to measure the thermal pain threshold | ||
| 520 | |a RESULTS: The results indicated that subcutaneous (s.c.) injection of nicotine (0.3 mg/kg) potentiated the analgesic response of intraperitoneal (i.p.) administration of morphine (3 mg/kg). Systemic administration of the same doses of nicotine or morphine alone had no effect on tail-flick latency. Intra-ACC administration of apomorphine (0.3-0.9 μg/rat), the non-selective D1/D2 receptors agonist, plus ineffective doses of nicotine (0.1 mg/kg, s.c.) plus morphine (3 mg/kg, i.p) induced analgesia in rats. In addition, the analgesia induced with co-administration of nicotine and morphine was inhibited via intra-ACC administration of SCH23390 (0.5-1 μg/rat) or sulpiride (0.5-2 μg/rat), the selective antagonists of D1 or D2 receptors, respectively. The intra-ACC microinjection of the same doses of drugs alone had no effect on tail-flick latency. Cubic interpolation analysis also confirmed that activation or inactivation of the ACC D1 and D2 receptors by different doses of drugs can modulate the nicotine-morphine analgesic response | ||
| 520 | |a CONCLUSIONS: The findings suggest that the ACC has an important role in acute thermal pain perception and modulates the analgesia induced by nicotine plus morphine via dopaminergic receptors | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Analgesia | |
| 650 | 4 | |a Anterior cingulate cortex | |
| 650 | 4 | |a D1 and D2 dopamine receptors | |
| 650 | 4 | |a Morphine | |
| 650 | 4 | |a Nicotine | |
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| 650 | 7 | |a Benzazepines |2 NLM | |
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| 700 | 1 | |a Sardari, Sara |e verfasserin |4 aut | |
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