Value of [18F]FDG PET-CT in the follow-up of surgically treated oral tongue squamous cell carcinoma : single centre cohort analysis on 87 patients
BACKGROUND: To evaluate the diagnostic performance of [¹⁸F]fluorodeoxyglucose positron emission tomography/computed tomography ([¹⁸F]FDG-PET/CT) scan in detecting local recurrences in patients with surgically treated oral tongue squamous cell cancer (OTSCC).
MATERIAL AND METHODS: Eighty-seven patients who had undergone surgery for OTSCC were monitored clinically and [¹⁸F]FDGPET/CT and magnetic resonance (MR). PET uptakes were classified as functional (Type A), suspicious (Type B), or highly suggestive of local recurrence (Type C). A multidisciplinary team (MDT) evaluated case-by-case the surveillance strategy based on PET uptake.
RESULTS: Fifty-nine patients presented FDG-PET uptake during follow-up: this report was significantly more frequent in patients who received flap reconstruction than in those without (73% vs 50%; p = 0.05). In 13 patients with Type A (n = 1), Type B (n = 9), and Type C (n = 3) uptakes an additional MR was considered preferable and discovered recurrence in 12.PET-CT had 9 true positives, 17 false positives, 71 true negatives, and no false-negative, resulting in sensitivity, specificity, positive (PPV) and negative predictive values (NPV) of 100%, 80.7%, 34.6%, and 100%.
CONCLUSIONS: The present results demonstrated a change in diagnostic strategy, as decided by the MDT, in about one-fifth of patients. The results should prompt in designing a rational surveillance schedule in surgically treated OTSCC.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:24 |
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| Enthalten in: |
Nuclear medicine review. Central & Eastern Europe - 24(2021), 2 vom: 02., Seite 58-62 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ravanelli, Marco [VerfasserIn] |
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| Links: |
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| Themen: |
[18F]FDG PET/CT |
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| Anmerkungen: |
Date Completed 28.10.2021 Date Revised 28.10.2021 published: Print Citation Status MEDLINE |
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| doi: |
10.5603/NMR.2021.0016 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM329265407 |
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| 100 | 1 | |a Ravanelli, Marco |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Value of [18F]FDG PET-CT in the follow-up of surgically treated oral tongue squamous cell carcinoma |b single centre cohort analysis on 87 patients |
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| 520 | |a BACKGROUND: To evaluate the diagnostic performance of [¹⁸F]fluorodeoxyglucose positron emission tomography/computed tomography ([¹⁸F]FDG-PET/CT) scan in detecting local recurrences in patients with surgically treated oral tongue squamous cell cancer (OTSCC) | ||
| 520 | |a MATERIAL AND METHODS: Eighty-seven patients who had undergone surgery for OTSCC were monitored clinically and [¹⁸F]FDGPET/CT and magnetic resonance (MR). PET uptakes were classified as functional (Type A), suspicious (Type B), or highly suggestive of local recurrence (Type C). A multidisciplinary team (MDT) evaluated case-by-case the surveillance strategy based on PET uptake | ||
| 520 | |a RESULTS: Fifty-nine patients presented FDG-PET uptake during follow-up: this report was significantly more frequent in patients who received flap reconstruction than in those without (73% vs 50%; p = 0.05). In 13 patients with Type A (n = 1), Type B (n = 9), and Type C (n = 3) uptakes an additional MR was considered preferable and discovered recurrence in 12.PET-CT had 9 true positives, 17 false positives, 71 true negatives, and no false-negative, resulting in sensitivity, specificity, positive (PPV) and negative predictive values (NPV) of 100%, 80.7%, 34.6%, and 100% | ||
| 520 | |a CONCLUSIONS: The present results demonstrated a change in diagnostic strategy, as decided by the MDT, in about one-fifth of patients. The results should prompt in designing a rational surveillance schedule in surgically treated OTSCC | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a PET/CT | |
| 650 | 4 | |a [18F]FDG PET/CT | |
| 650 | 4 | |a magnetic resonance imaging | |
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| 700 | 1 | |a Squassina, Guido |e verfasserin |4 aut | |
| 700 | 1 | |a Bertagna, Francesco |e verfasserin |4 aut | |
| 700 | 1 | |a Albano, Domenico |e verfasserin |4 aut | |
| 700 | 1 | |a Lancini, Davide |e verfasserin |4 aut | |
| 700 | 1 | |a Bosio, Paolo |e verfasserin |4 aut | |
| 700 | 1 | |a Zigliani, Angelo |e verfasserin |4 aut | |
| 700 | 1 | |a Agazzi, Giorgio Maria |e verfasserin |4 aut | |
| 700 | 1 | |a Maroldi, Roberto |e verfasserin |4 aut | |
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| 700 | 1 | |a Farina, Davide |e verfasserin |4 aut | |
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