Childhood Trajectories of Hyperactivity/Inattention Symptoms and Diurnal Cortisol in Middle Adolescence : Results from a UK Birth Cohort
OBJECTIVE: Children with attention-deficit/hyperactivity disorder (ADHD) show hypoactivity of the hypothalamic-pituitary-adrenal (HPA) axis. Whether the association between hyperactivity/inattention symptoms with HPA axis dysfunction holds in the general child population too is not clear.
METHOD: We assessed associations between longitudinal trajectories of hyperactivity/inattention symptoms during ages 4 to 13 years and basal cortisol profiles at age 15 in a British general population cohort.
RESULTS: Adolescents with persistently high levels of hyperactivity/inattention symptoms since childhood showed lower total morning cortisol and a smaller diurnal decline, even after adjusting for confounders. No associations were found between any of the symptom trajectories and cortisol awakening response, diurnal slope or daily output of cortisol.
CONCLUSION: This study provides evidence for hypocortisolism among adolescents with chronic hyperactivity/inattention symptoms in the general population.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:26 |
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| Enthalten in: |
Journal of attention disorders - 26(2022), 6 vom: 01. Apr., Seite 809-821 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Ji, Dongying [VerfasserIn] |
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| Links: |
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| Themen: |
ALSPAC |
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| Anmerkungen: |
Date Completed 21.03.2022 Date Revised 21.03.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1177/10870547211036755 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM329223801 |
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| 245 | 1 | 0 | |a Childhood Trajectories of Hyperactivity/Inattention Symptoms and Diurnal Cortisol in Middle Adolescence |b Results from a UK Birth Cohort |
| 264 | 1 | |c 2022 | |
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| 500 | |a Date Revised 21.03.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a OBJECTIVE: Children with attention-deficit/hyperactivity disorder (ADHD) show hypoactivity of the hypothalamic-pituitary-adrenal (HPA) axis. Whether the association between hyperactivity/inattention symptoms with HPA axis dysfunction holds in the general child population too is not clear | ||
| 520 | |a METHOD: We assessed associations between longitudinal trajectories of hyperactivity/inattention symptoms during ages 4 to 13 years and basal cortisol profiles at age 15 in a British general population cohort | ||
| 520 | |a RESULTS: Adolescents with persistently high levels of hyperactivity/inattention symptoms since childhood showed lower total morning cortisol and a smaller diurnal decline, even after adjusting for confounders. No associations were found between any of the symptom trajectories and cortisol awakening response, diurnal slope or daily output of cortisol | ||
| 520 | |a CONCLUSION: This study provides evidence for hypocortisolism among adolescents with chronic hyperactivity/inattention symptoms in the general population | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a adolescence | |
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| 700 | 1 | |a Francesconi, Marta |e verfasserin |4 aut | |
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