Cross-sectional study of aortic valve calcification and cardiovascular risk factors in older Danish men
© Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ..
OBJECTIVE: Aortic valve calcification (AVC) and coronary artery calcification (CAC) are predictors of cardiovascular disease (CVD), presumably sharing risk factors. Our objectives were to determine the prevalence and extent of AVC in a large population of men aged 60-74 years and to assess the association between AVC and cardiovascular risk factors including CAC and biomarkers.
METHODS: Participants from the DANish CArdioVAscular Screening and intervention trial (DANCAVAS) with AVC and CAC scores and without previous valve replacement were included in the study. Calcification scores were calculated on non-contrast CT scans. Cardiovascular risk factors were self-reported, measured or both, and further explored using descriptive and regression analysis for AVC association.
RESULTS: 14 073 men aged 60-74 years were included. The AVC scores ranged from 0 to 9067 AU, with a median AVC of 6 AU (IQR 0-82). In 8156 individuals (58.0%), the AVC score was >0 and 215 (1.5%) had an AVC score ≥1200. In the regression analysis, all cardiovascular risk factors were associated with AVC; however, after inclusion of CAC ≥400, only age (ratio of expected counts (REC) 1.07 (95% CI 1.06 to 1.09)), hypertension (REC 1.24 (95% CI 1.09 to 1.41)), obesity (REC 1.34 (95% CI 1.20 to 1.50)), known CVD (REC 1.16 (95% CI 1.03 to 1.31)) and serum phosphate (REC 2.25 (95% CI 1.66 to 3.10) remained significantly associated, while smoking, diabetes, hyperlipidaemia, estimated glomerular filtration rate and serum calcium were not.
CONCLUSIONS: AVC was prevalent in the general population of men aged 60-74 years and was significantly associated with all modifiable cardiovascular risk factors, but only selectively after adjustment for CAC ≥400 AU.
TRIAL REGISTRATION NUMBER: NCT03946410 and ISRCTN12157806.
| Errataetall: |
CommentIn: Heart. 2021 Oct;107(19):1524-1525. - PMID 34376489 |
|---|---|
| Medienart: |
E-Artikel |
| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:107 |
|---|---|
| Enthalten in: |
Heart (British Cardiac Society) - 107(2021), 19 vom: 10. Okt., Seite 1536-1543 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Khurrami, Lida [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Coronary angiography |
|---|
| Anmerkungen: |
Date Completed 08.12.2021 Date Revised 14.12.2021 published: Print-Electronic ClinicalTrials.gov: NCT03946410 ISRCTN: ISRCTN12157806 CommentIn: Heart. 2021 Oct;107(19):1524-1525. - PMID 34376489 Citation Status MEDLINE |
|---|
| doi: |
10.1136/heartjnl-2021-319023 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM329204661 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM329204661 | ||
| 003 | DE-627 | ||
| 005 | 20231225204618.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1136/heartjnl-2021-319023 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1097.xml |
| 035 | |a (DE-627)NLM329204661 | ||
| 035 | |a (NLM)34376488 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Khurrami, Lida |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Cross-sectional study of aortic valve calcification and cardiovascular risk factors in older Danish men |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 08.12.2021 | ||
| 500 | |a Date Revised 14.12.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a ClinicalTrials.gov: NCT03946410 | ||
| 500 | |a ISRCTN: ISRCTN12157806 | ||
| 500 | |a CommentIn: Heart. 2021 Oct;107(19):1524-1525. - PMID 34376489 | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © Author(s) (or their employer(s)) 2021. No commercial re-use. See rights and permissions. Published by BMJ. | ||
| 520 | |a OBJECTIVE: Aortic valve calcification (AVC) and coronary artery calcification (CAC) are predictors of cardiovascular disease (CVD), presumably sharing risk factors. Our objectives were to determine the prevalence and extent of AVC in a large population of men aged 60-74 years and to assess the association between AVC and cardiovascular risk factors including CAC and biomarkers | ||
| 520 | |a METHODS: Participants from the DANish CArdioVAscular Screening and intervention trial (DANCAVAS) with AVC and CAC scores and without previous valve replacement were included in the study. Calcification scores were calculated on non-contrast CT scans. Cardiovascular risk factors were self-reported, measured or both, and further explored using descriptive and regression analysis for AVC association | ||
| 520 | |a RESULTS: 14 073 men aged 60-74 years were included. The AVC scores ranged from 0 to 9067 AU, with a median AVC of 6 AU (IQR 0-82). In 8156 individuals (58.0%), the AVC score was >0 and 215 (1.5%) had an AVC score ≥1200. In the regression analysis, all cardiovascular risk factors were associated with AVC; however, after inclusion of CAC ≥400, only age (ratio of expected counts (REC) 1.07 (95% CI 1.06 to 1.09)), hypertension (REC 1.24 (95% CI 1.09 to 1.41)), obesity (REC 1.34 (95% CI 1.20 to 1.50)), known CVD (REC 1.16 (95% CI 1.03 to 1.31)) and serum phosphate (REC 2.25 (95% CI 1.66 to 3.10) remained significantly associated, while smoking, diabetes, hyperlipidaemia, estimated glomerular filtration rate and serum calcium were not | ||
| 520 | |a CONCLUSIONS: AVC was prevalent in the general population of men aged 60-74 years and was significantly associated with all modifiable cardiovascular risk factors, but only selectively after adjustment for CAC ≥400 AU | ||
| 520 | |a TRIAL REGISTRATION NUMBER: NCT03946410 and ISRCTN12157806 | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Multicenter Study | |
| 650 | 4 | |a Randomized Controlled Trial | |
| 650 | 4 | |a coronary angiography | |
| 650 | 4 | |a coronary artery disease | |
| 650 | 4 | |a diagnostic imaging | |
| 650 | 4 | |a heart valve diseases | |
| 650 | 4 | |a risk factors | |
| 700 | 1 | |a Møller, Jacob Eifer |e verfasserin |4 aut | |
| 700 | 1 | |a Lindholt, Jes Sanddal |e verfasserin |4 aut | |
| 700 | 1 | |a Urbonaviciene, Grazina |e verfasserin |4 aut | |
| 700 | 1 | |a Steffensen, Flemming Hald |e verfasserin |4 aut | |
| 700 | 1 | |a Lambrechtsen, Jess |e verfasserin |4 aut | |
| 700 | 1 | |a Karon, Marek |e verfasserin |4 aut | |
| 700 | 1 | |a Frost, Lars |e verfasserin |4 aut | |
| 700 | 1 | |a Busk, Martin |e verfasserin |4 aut | |
| 700 | 1 | |a Egstrup, Kenneth |e verfasserin |4 aut | |
| 700 | 1 | |a Fredgart, Maise Høigaard |e verfasserin |4 aut | |
| 700 | 1 | |a Diederichsen, Axel Cosmus Pyndt |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Heart (British Cardiac Society) |d 1996 |g 107(2021), 19 vom: 10. Okt., Seite 1536-1543 |w (DE-627)NLM085989274 |x 1468-201X |7 nnns |
| 773 | 1 | 8 | |g volume:107 |g year:2021 |g number:19 |g day:10 |g month:10 |g pages:1536-1543 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1136/heartjnl-2021-319023 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 107 |j 2021 |e 19 |b 10 |c 10 |h 1536-1543 | ||