Subacute Toxicity Evaluation of Methanolic Extract of Syzygium polyanthum in Rats
© Penerbit Universiti Sains Malaysia, 2021..
Syzygium polyanthum (Wight) Walp. var. polyanthum (serai kayu) leaves is a popular herb and widely used in traditional medicine. Despite the ethnomedicinal benefits, very limited studies have researched on the toxicity of this plant. The aim of the present study was to investigate the potential effects of methanolic extract of Syzygium polyanthum (MESP) leaves via 28-day repeated oral dosing in Sprague Dawley rats. MESP leaves was administered at doses of 0 (control), 400, 1000 or 2000 mg/kg to an equal number of male and female rats (n = 10/group). Results obtained indicated that MESP did not affect the general conditions (body weight, feed intake and oestrous cycle) and apparent behavioural changes of the rats. Biochemical parameters revealed a slight significant variation in the aspartate aminotransferase (AST) level between the male rats treated with the lowest and highest doses of MESP, but these findings were both statistically insignificant when compared to the control group. The liver of the males (dose 1000 and 2000 mg/kg/day) also exhibited histoarchitectural defects on the hepatocytes and cytoplasm when compared to those of the control group. In contrast, female rats did not encounter any significant findings in all parameters tested. In conclusion, this study suggests that the MESP leaves might exhibit sex-based variation effects and thus, the use of this extract particularly at higher doses should be thoroughly considered.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2021 |
|---|---|
| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:32 |
|---|---|
| Enthalten in: |
Tropical life sciences research - 32(2021), 2 vom: 28. Juni, Seite 65-81 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Harun, Nor Hazliana [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
Dilatasi Sinusoid |
|---|
| Anmerkungen: |
Date Revised 10.08.2021 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
|---|
| doi: |
10.21315/tlsr2021.32.2.5 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM329116754 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM329116754 | ||
| 003 | DE-627 | ||
| 005 | 20231225204419.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2021 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.21315/tlsr2021.32.2.5 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1097.xml |
| 035 | |a (DE-627)NLM329116754 | ||
| 035 | |a (NLM)34367515 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Harun, Nor Hazliana |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Subacute Toxicity Evaluation of Methanolic Extract of Syzygium polyanthum in Rats |
| 264 | 1 | |c 2021 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 10.08.2021 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © Penerbit Universiti Sains Malaysia, 2021. | ||
| 520 | |a Syzygium polyanthum (Wight) Walp. var. polyanthum (serai kayu) leaves is a popular herb and widely used in traditional medicine. Despite the ethnomedicinal benefits, very limited studies have researched on the toxicity of this plant. The aim of the present study was to investigate the potential effects of methanolic extract of Syzygium polyanthum (MESP) leaves via 28-day repeated oral dosing in Sprague Dawley rats. MESP leaves was administered at doses of 0 (control), 400, 1000 or 2000 mg/kg to an equal number of male and female rats (n = 10/group). Results obtained indicated that MESP did not affect the general conditions (body weight, feed intake and oestrous cycle) and apparent behavioural changes of the rats. Biochemical parameters revealed a slight significant variation in the aspartate aminotransferase (AST) level between the male rats treated with the lowest and highest doses of MESP, but these findings were both statistically insignificant when compared to the control group. The liver of the males (dose 1000 and 2000 mg/kg/day) also exhibited histoarchitectural defects on the hepatocytes and cytoplasm when compared to those of the control group. In contrast, female rats did not encounter any significant findings in all parameters tested. In conclusion, this study suggests that the MESP leaves might exhibit sex-based variation effects and thus, the use of this extract particularly at higher doses should be thoroughly considered | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Dilatasi Sinusoid | |
| 650 | 4 | |a Ekstrak Metanol | |
| 650 | 4 | |a Ketoksikan Subakut | |
| 650 | 4 | |a Methanolic Extract | |
| 650 | 4 | |a Sinusoidal Dilatation | |
| 650 | 4 | |a Subacute Toxicity | |
| 650 | 4 | |a Syzygium polyanthum | |
| 700 | 1 | |a Rasdi, Nor Atiqah |e verfasserin |4 aut | |
| 700 | 1 | |a Salleh, Rabeta Mohd |e verfasserin |4 aut | |
| 700 | 1 | |a Safuan, Sabreena |e verfasserin |4 aut | |
| 700 | 1 | |a Ahmad, Wan Amir Nizam Wan |e verfasserin |4 aut | |
| 700 | 1 | |a Fuad, Wan Ezumi Mohd |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Tropical life sciences research |d 2009 |g 32(2021), 2 vom: 28. Juni, Seite 65-81 |w (DE-627)NLM235902462 |x 1985-3718 |7 nnns |
| 773 | 1 | 8 | |g volume:32 |g year:2021 |g number:2 |g day:28 |g month:06 |g pages:65-81 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.21315/tlsr2021.32.2.5 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 32 |j 2021 |e 2 |b 28 |c 06 |h 65-81 | ||