A prospective investigation of pain and fatigue following pelvic exenteration
Copyright © 2021 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved..
AIM: To describe the long-term course of pain and fatigue in patients undergoing pelvic exenteration and to evaluate potential prognostic factors for these outcomes.
DESIGN: Prospective cohort study.
SETTINGS: Royal Prince Alfred Hospital, Sydney, Australia.
PATIENTS: Consecutive patients undergoing pelvic exenteration surgery between July 2008 and December 2017.
MAIN OUTCOME MEASURES: Pain and fatigue scores collected via SF-36v2 Health surveys pre-operatively and at eight time-points post-operatively for a period of 5-years. The course of pain and fatigue were described according to the following prognostic factors; bone resection (yes/no), cancer type (primary/recurrent), margin status (R0/R1-2) and extent of exenteration (complete/partial).
RESULTS: 345 of 459 eligible patients (75 %) consented to the study. The course of pain and fatigue over the 5 year follow-up was favourable. Patients undergoing pelvic exenteration with an R0 resection margin or without bone resection presented lower pain levels throughout the follow-up period. Bone resection, positive surgical margin (R1/R2) and type of cancer did not influence fatigue trajectories. Patients undergoing complete pelvic exenteration were more likely to report a higher level of pain and fatigue in the initial follow-up period, however this difference was not observed in the longer-term.
CONCLUSIONS: Patients undergoing PE (Austin and Solomon, 2015) [1] can expect improvement but an incomplete recovery in the levels of pain and fatigue postoperatively over the 5-year follow-up period. Bone resection as part of exenteration demonstrated higher levels of pain and fatigue.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2021 |
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| Erschienen: |
2021 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:47 |
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| Enthalten in: |
European journal of surgical oncology : the journal of the European Society of Surgical Oncology and the British Association of Surgical Oncology - 47(2021), 12 vom: 26. Dez., Seite 3137-3143 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Vuong, Kenneth [VerfasserIn] |
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| Links: |
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| Themen: |
Cancer |
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| Anmerkungen: |
Date Completed 16.02.2022 Date Revised 16.02.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.1016/j.ejso.2021.07.022 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM329103326 |
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| 100 | 1 | |a Vuong, Kenneth |e verfasserin |4 aut | |
| 245 | 1 | 2 | |a A prospective investigation of pain and fatigue following pelvic exenteration |
| 264 | 1 | |c 2021 | |
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| 500 | |a Date Completed 16.02.2022 | ||
| 500 | |a Date Revised 16.02.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Copyright © 2021 Elsevier Ltd, BASO ~ The Association for Cancer Surgery, and the European Society of Surgical Oncology. All rights reserved. | ||
| 520 | |a AIM: To describe the long-term course of pain and fatigue in patients undergoing pelvic exenteration and to evaluate potential prognostic factors for these outcomes | ||
| 520 | |a DESIGN: Prospective cohort study | ||
| 520 | |a SETTINGS: Royal Prince Alfred Hospital, Sydney, Australia | ||
| 520 | |a PATIENTS: Consecutive patients undergoing pelvic exenteration surgery between July 2008 and December 2017 | ||
| 520 | |a MAIN OUTCOME MEASURES: Pain and fatigue scores collected via SF-36v2 Health surveys pre-operatively and at eight time-points post-operatively for a period of 5-years. The course of pain and fatigue were described according to the following prognostic factors; bone resection (yes/no), cancer type (primary/recurrent), margin status (R0/R1-2) and extent of exenteration (complete/partial) | ||
| 520 | |a RESULTS: 345 of 459 eligible patients (75 %) consented to the study. The course of pain and fatigue over the 5 year follow-up was favourable. Patients undergoing pelvic exenteration with an R0 resection margin or without bone resection presented lower pain levels throughout the follow-up period. Bone resection, positive surgical margin (R1/R2) and type of cancer did not influence fatigue trajectories. Patients undergoing complete pelvic exenteration were more likely to report a higher level of pain and fatigue in the initial follow-up period, however this difference was not observed in the longer-term | ||
| 520 | |a CONCLUSIONS: Patients undergoing PE (Austin and Solomon, 2015) [1] can expect improvement but an incomplete recovery in the levels of pain and fatigue postoperatively over the 5-year follow-up period. Bone resection as part of exenteration demonstrated higher levels of pain and fatigue | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Cancer | |
| 650 | 4 | |a Clinical course | |
| 650 | 4 | |a Fatigue | |
| 650 | 4 | |a Pain | |
| 650 | 4 | |a Pelvic exenteration | |
| 700 | 1 | |a Alchin, Lyndal M |e verfasserin |4 aut | |
| 700 | 1 | |a Solomon, Michael J |e verfasserin |4 aut | |
| 700 | 1 | |a Koh, Cherry E |e verfasserin |4 aut | |
| 700 | 1 | |a Steffens, Daniel |e verfasserin |4 aut | |
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