Clinical and peculiar immunological manifestations of SARS-CoV-2 infection in systemic lupus erythematosus patients
© The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissionsoup.com..
OBJECTIVES: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in patients with SLE remains unclear and data on clinical manifestations after infection are lacking. The aim of this multicentre study is to describe the effect of SARS-CoV-2 in SLE patients.
METHODS: SLE patients referring to four Italian centres were monitored between February 2020 and March 2021. All patients with SARS-CoV-2 infection were included. Disease characteristics, treatment, disease activity and SARS-CoV-2-related symptoms were recorded before and after the infection.
RESULTS: Fifty-one (6.14%) SLE patients were included among 830 who were regularly followed up. Nine (17.6%) had an asymptomatic infection and 5 (9.8%) out of 42 (82.6%) symptomatic patients developed interstitial pneumonia (no identified risk factor). The presence of SLE major organ involvement (particularly renal involvement) was associated with asymptomatic SARS-CoV-2 infection (P = 0.02). Chronic corticosteroid therapy was found to be associated with asymptomatic infection (P = 0.018). Three SLE flares (5.9%) were developed after SARS-CoV-2 infection: one of them was characterized by MPO-ANCA-positive pauci-immune crescentic necrotizing glomerulonephritis and granulomatous pneumonia.
CONCLUSIONS: SARS-CoV-2 infection determined autoimmune flares in a small number of patients. Our data seem to confirm that there was not an increased risk of SARS-CoV-2 in SLE. Patients with asymptomatic SARS-CoV-2 infections were those having major SLE organ involvement. This may be explained by the high doses of corticosteroids and immunosuppressive agents used for SLE treatment.
Medienart: |
E-Artikel |
---|
Erscheinungsjahr: |
2022 |
---|---|
Erschienen: |
2022 |
Enthalten in: |
Zur Gesamtaufnahme - volume:61 |
---|---|
Enthalten in: |
Rheumatology (Oxford, England) - 61(2022), 5 vom: 05. Mai, Seite 1928-1935 |
Sprache: |
Englisch |
---|
Beteiligte Personen: |
Schioppo, Tommaso [VerfasserIn] |
---|
Links: |
---|
Themen: |
COVID-19 |
---|
Anmerkungen: |
Date Completed 09.05.2022 Date Revised 25.05.2022 published: Print Citation Status MEDLINE |
---|
doi: |
10.1093/rheumatology/keab611 |
---|
funding: |
|
---|---|
Förderinstitution / Projekttitel: |
|
PPN (Katalog-ID): |
NLM328963917 |
---|
LEADER | 01000naa a22002652 4500 | ||
---|---|---|---|
001 | NLM328963917 | ||
003 | DE-627 | ||
005 | 20231225204056.0 | ||
007 | cr uuu---uuuuu | ||
008 | 231225s2022 xx |||||o 00| ||eng c | ||
024 | 7 | |a 10.1093/rheumatology/keab611 |2 doi | |
028 | 5 | 2 | |a pubmed24n1096.xml |
035 | |a (DE-627)NLM328963917 | ||
035 | |a (NLM)34352079 | ||
040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
041 | |a eng | ||
100 | 1 | |a Schioppo, Tommaso |e verfasserin |4 aut | |
245 | 1 | 0 | |a Clinical and peculiar immunological manifestations of SARS-CoV-2 infection in systemic lupus erythematosus patients |
264 | 1 | |c 2022 | |
336 | |a Text |b txt |2 rdacontent | ||
337 | |a ƒaComputermedien |b c |2 rdamedia | ||
338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
500 | |a Date Completed 09.05.2022 | ||
500 | |a Date Revised 25.05.2022 | ||
500 | |a published: Print | ||
500 | |a Citation Status MEDLINE | ||
520 | |a © The Author(s) 2021. Published by Oxford University Press on behalf of the British Society for Rheumatology. All rights reserved. For permissions, please email: journals.permissionsoup.com. | ||
520 | |a OBJECTIVES: The impact of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in patients with SLE remains unclear and data on clinical manifestations after infection are lacking. The aim of this multicentre study is to describe the effect of SARS-CoV-2 in SLE patients | ||
520 | |a METHODS: SLE patients referring to four Italian centres were monitored between February 2020 and March 2021. All patients with SARS-CoV-2 infection were included. Disease characteristics, treatment, disease activity and SARS-CoV-2-related symptoms were recorded before and after the infection | ||
520 | |a RESULTS: Fifty-one (6.14%) SLE patients were included among 830 who were regularly followed up. Nine (17.6%) had an asymptomatic infection and 5 (9.8%) out of 42 (82.6%) symptomatic patients developed interstitial pneumonia (no identified risk factor). The presence of SLE major organ involvement (particularly renal involvement) was associated with asymptomatic SARS-CoV-2 infection (P = 0.02). Chronic corticosteroid therapy was found to be associated with asymptomatic infection (P = 0.018). Three SLE flares (5.9%) were developed after SARS-CoV-2 infection: one of them was characterized by MPO-ANCA-positive pauci-immune crescentic necrotizing glomerulonephritis and granulomatous pneumonia | ||
520 | |a CONCLUSIONS: SARS-CoV-2 infection determined autoimmune flares in a small number of patients. Our data seem to confirm that there was not an increased risk of SARS-CoV-2 in SLE. Patients with asymptomatic SARS-CoV-2 infections were those having major SLE organ involvement. This may be explained by the high doses of corticosteroids and immunosuppressive agents used for SLE treatment | ||
650 | 4 | |a Journal Article | |
650 | 4 | |a Multicenter Study | |
650 | 4 | |a COVID-19 | |
650 | 4 | |a SARS-CoV-2 infection | |
650 | 4 | |a SLE | |
650 | 4 | |a disease activity | |
650 | 4 | |a flare | |
650 | 7 | |a Immunosuppressive Agents |2 NLM | |
700 | 1 | |a Argolini, Lorenza Maria |e verfasserin |4 aut | |
700 | 1 | |a Sciascia, Savino |e verfasserin |4 aut | |
700 | 1 | |a Pregnolato, Francesca |e verfasserin |4 aut | |
700 | 1 | |a Tamborini, Francesco |e verfasserin |4 aut | |
700 | 1 | |a Miraglia, Paolo |e verfasserin |4 aut | |
700 | 1 | |a Roccatello, Dario |e verfasserin |4 aut | |
700 | 1 | |a Sinico, Renato Alberto |e verfasserin |4 aut | |
700 | 1 | |a Caporali, Roberto |e verfasserin |4 aut | |
700 | 1 | |a Moroni, Gabriella |e verfasserin |4 aut | |
700 | 1 | |a Gerosa, Maria |e verfasserin |4 aut | |
773 | 0 | 8 | |i Enthalten in |t Rheumatology (Oxford, England) |d 1999 |g 61(2022), 5 vom: 05. Mai, Seite 1928-1935 |w (DE-627)NLM102581908 |x 1462-0332 |7 nnns |
773 | 1 | 8 | |g volume:61 |g year:2022 |g number:5 |g day:05 |g month:05 |g pages:1928-1935 |
856 | 4 | 0 | |u http://dx.doi.org/10.1093/rheumatology/keab611 |3 Volltext |
912 | |a GBV_USEFLAG_A | ||
912 | |a GBV_NLM | ||
951 | |a AR | ||
952 | |d 61 |j 2022 |e 5 |b 05 |c 05 |h 1928-1935 |