Efficacy and Safety of Tranexamic Acid for the Control of Surgical Bleeding in Patients Under Liposuction
© 2021. Springer Science+Business Media, LLC, part of Springer Nature and International Society of Aesthetic Plastic Surgery..
Liposuction remains one of the most frequently performed cosmetic surgical procedures and its popularity is increasing every year. However, since its inception, justified concerns regarding patient safety have placed limits on the volume of fat that can be aspirated, influenced by hemodynamic fluctuations and blood loss during liposuction. Tranexamic acid (TXA) is an antifibrinolytic agent that competitively inhibits the conversion of plasminogen to plasmin, thus preventing the binding and degradation of fibrin. Despite the existence of evidence of the effectiveness of TXA in orthopedic and cardiac surgeries, there is little evidence of its use in liposuction. The objective of this study was to evaluate the efficacy and safety of tranexamic acid in the control of surgical bleeding in patients undergoing liposuction, through a prospective, open, randomized and controlled clinical trial. Two groups of 25 participants each were formed to whom the application of TXA in a tumescent solution prior to liposuction or liposuction with the traditional technique was randomly assigned. The results showed a decrease in blood loss reflected by the differences in the final hematocrit values, as well as decrease in the same per aspirated volume (p = 0.003). No adverse events were found related with the TXA application and no blood transfusions were required in this group, in contrast to the control group where the need for blood transfusion was present in 20% of the intervened participants. LEVEL OF EVIDENCE II: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2022 |
|---|---|
| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:46 |
|---|---|
| Enthalten in: |
Aesthetic plastic surgery - 46(2022), 1 vom: 05. Feb., Seite 258-264 |
| Sprache: |
Englisch |
|---|
| Beteiligte Personen: |
Rodríguez-García, F A [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
6T84R30KC1 |
|---|
| Anmerkungen: |
Date Completed 16.03.2022 Date Revised 16.03.2022 published: Print-Electronic Citation Status MEDLINE |
|---|
| doi: |
10.1007/s00266-021-02486-y |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM328958344 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM328958344 | ||
| 003 | DE-627 | ||
| 005 | 20231225204048.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2022 xx |||||o 00| ||eng c | ||
| 024 | 7 | |a 10.1007/s00266-021-02486-y |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1096.xml |
| 035 | |a (DE-627)NLM328958344 | ||
| 035 | |a (NLM)34351508 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a eng | ||
| 100 | 1 | |a Rodríguez-García, F A |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Efficacy and Safety of Tranexamic Acid for the Control of Surgical Bleeding in Patients Under Liposuction |
| 264 | 1 | |c 2022 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Completed 16.03.2022 | ||
| 500 | |a Date Revised 16.03.2022 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status MEDLINE | ||
| 520 | |a © 2021. Springer Science+Business Media, LLC, part of Springer Nature and International Society of Aesthetic Plastic Surgery. | ||
| 520 | |a Liposuction remains one of the most frequently performed cosmetic surgical procedures and its popularity is increasing every year. However, since its inception, justified concerns regarding patient safety have placed limits on the volume of fat that can be aspirated, influenced by hemodynamic fluctuations and blood loss during liposuction. Tranexamic acid (TXA) is an antifibrinolytic agent that competitively inhibits the conversion of plasminogen to plasmin, thus preventing the binding and degradation of fibrin. Despite the existence of evidence of the effectiveness of TXA in orthopedic and cardiac surgeries, there is little evidence of its use in liposuction. The objective of this study was to evaluate the efficacy and safety of tranexamic acid in the control of surgical bleeding in patients undergoing liposuction, through a prospective, open, randomized and controlled clinical trial. Two groups of 25 participants each were formed to whom the application of TXA in a tumescent solution prior to liposuction or liposuction with the traditional technique was randomly assigned. The results showed a decrease in blood loss reflected by the differences in the final hematocrit values, as well as decrease in the same per aspirated volume (p = 0.003). No adverse events were found related with the TXA application and no blood transfusions were required in this group, in contrast to the control group where the need for blood transfusion was present in 20% of the intervened participants. LEVEL OF EVIDENCE II: This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266 | ||
| 650 | 4 | |a Journal Article | |
| 650 | 4 | |a Randomized Controlled Trial | |
| 650 | 4 | |a Antifibrinolytic agents | |
| 650 | 4 | |a Cosmetic surgery | |
| 650 | 4 | |a Liposuction | |
| 650 | 4 | |a Tranexamic acid | |
| 650 | 7 | |a Tranexamic Acid |2 NLM | |
| 650 | 7 | |a 6T84R30KC1 |2 NLM | |
| 700 | 1 | |a Sánchez-Peña, M A |e verfasserin |4 aut | |
| 700 | 1 | |a de Andrea, G Talleri |e verfasserin |4 aut | |
| 700 | 1 | |a Villarreal-Salgado, J L |e verfasserin |4 aut | |
| 700 | 1 | |a Álvarez-Trejo, H J |e verfasserin |4 aut | |
| 700 | 1 | |a Medina-Quintana, V M |e verfasserin |4 aut | |
| 700 | 1 | |a García-Valenzuela, S E |e verfasserin |4 aut | |
| 700 | 1 | |a Morfin-Meza, K E |e verfasserin |4 aut | |
| 700 | 1 | |a Fierro-Rodríguez, D A |e verfasserin |4 aut | |
| 700 | 1 | |a Dorado-Hernández, E |e verfasserin |4 aut | |
| 700 | 1 | |a Bonilla-Catalán, P V |e verfasserin |4 aut | |
| 700 | 1 | |a Ramos-Maciel, J |e verfasserin |4 aut | |
| 700 | 1 | |a Romero-Algara, E |e verfasserin |4 aut | |
| 700 | 1 | |a Jiménez-Pavón, K E |e verfasserin |4 aut | |
| 700 | 1 | |a Torres-Salazar, Q L |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Aesthetic plastic surgery |d 1976 |g 46(2022), 1 vom: 05. Feb., Seite 258-264 |w (DE-627)NLM012961906 |x 1432-5241 |7 nnns |
| 773 | 1 | 8 | |g volume:46 |g year:2022 |g number:1 |g day:05 |g month:02 |g pages:258-264 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1007/s00266-021-02486-y |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 46 |j 2022 |e 1 |b 05 |c 02 |h 258-264 | ||