Posterior reversible encephalopathy syndrome in critical COVID-19 patients : Report of 2 cases
© 2021 Sociedad Española de Anestesiología, Reanimación y Terapéutica del Dolor. Published by Elsevier España, S.L.U. All rights reserved..
Posterior reversible encephalopathy syndrome is an acute neurological disorder characterized by variable symptoms and radiological images characteristic of vasogenic parietal-occipital edema. It is associated with clinical conditions such as high blood pressure, infection/sepsis, or cytotoxic/immunosuppressive drugs, among others. It is characterized pathophysiologically by endothelial damage with breakdown of blood-brain barrier, cerebral hypoperfusion, and vasogenic edema.The cases are presented on 2 critical COVID-19 patients who were admitted to pneumonia requiring mechanical ventilation and who, after removing sedation, developed acute and reversible neurological symptoms consisting of epilepsy and encephalopathy, associated with hyperintense subcortical lesions on brain magnetic resonance imaging compatible with posterior reversible encephalopathy syndrome.SARS-CoV-2 coronavirus would activate an inflammatory response that would damage brain endothelium. It could be triggered by cytokine release, as well as by direct viral injury, given that endothelium expresses ACE2 receptors. It could explain the possible association between posterior reversible encephalopathy syndrome and COVID-19.
| Medienart: |
E-Artikel |
|---|
| Erscheinungsjahr: |
2023 |
|---|---|
| Erschienen: |
2023 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:70 |
|---|---|
| Enthalten in: |
Revista espanola de anestesiologia y reanimacion - 70(2023), 1 vom: 03. Jan., Seite 51-55 |
| Sprache: |
Spanisch |
|---|
| Weiterer Titel: |
Síndrome de encefalopatía posterior reversible en pacientes críticos COVID-19: reporte de 2 casos |
|---|
| Beteiligte Personen: |
Tortajada Soler, J J [VerfasserIn] |
|---|
| Links: |
|---|
| Themen: |
COVID-19 |
|---|
| Anmerkungen: |
Date Revised 03.01.2023 published: Print-Electronic Citation Status PubMed-not-MEDLINE |
|---|
| doi: |
10.1016/j.redar.2021.05.022 |
|---|
| funding: |
|
|---|---|
| Förderinstitution / Projekttitel: |
|
| PPN (Katalog-ID): |
NLM328895059 |
|---|
| LEADER | 01000naa a22002652 4500 | ||
|---|---|---|---|
| 001 | NLM328895059 | ||
| 003 | DE-627 | ||
| 005 | 20231225203928.0 | ||
| 007 | cr uuu---uuuuu | ||
| 008 | 231225s2023 xx |||||o 00| ||spa c | ||
| 024 | 7 | |a 10.1016/j.redar.2021.05.022 |2 doi | |
| 028 | 5 | 2 | |a pubmed24n1096.xml |
| 035 | |a (DE-627)NLM328895059 | ||
| 035 | |a (NLM)34345055 | ||
| 040 | |a DE-627 |b ger |c DE-627 |e rakwb | ||
| 041 | |a spa | ||
| 100 | 1 | |a Tortajada Soler, J J |e verfasserin |4 aut | |
| 245 | 1 | 0 | |a Posterior reversible encephalopathy syndrome in critical COVID-19 patients |b Report of 2 cases |
| 246 | 3 | 3 | |a Síndrome de encefalopatía posterior reversible en pacientes críticos COVID-19: reporte de 2 casos |
| 264 | 1 | |c 2023 | |
| 336 | |a Text |b txt |2 rdacontent | ||
| 337 | |a ƒaComputermedien |b c |2 rdamedia | ||
| 338 | |a ƒa Online-Ressource |b cr |2 rdacarrier | ||
| 500 | |a Date Revised 03.01.2023 | ||
| 500 | |a published: Print-Electronic | ||
| 500 | |a Citation Status PubMed-not-MEDLINE | ||
| 520 | |a © 2021 Sociedad Española de Anestesiología, Reanimación y Terapéutica del Dolor. Published by Elsevier España, S.L.U. All rights reserved. | ||
| 520 | |a Posterior reversible encephalopathy syndrome is an acute neurological disorder characterized by variable symptoms and radiological images characteristic of vasogenic parietal-occipital edema. It is associated with clinical conditions such as high blood pressure, infection/sepsis, or cytotoxic/immunosuppressive drugs, among others. It is characterized pathophysiologically by endothelial damage with breakdown of blood-brain barrier, cerebral hypoperfusion, and vasogenic edema.The cases are presented on 2 critical COVID-19 patients who were admitted to pneumonia requiring mechanical ventilation and who, after removing sedation, developed acute and reversible neurological symptoms consisting of epilepsy and encephalopathy, associated with hyperintense subcortical lesions on brain magnetic resonance imaging compatible with posterior reversible encephalopathy syndrome.SARS-CoV-2 coronavirus would activate an inflammatory response that would damage brain endothelium. It could be triggered by cytokine release, as well as by direct viral injury, given that endothelium expresses ACE2 receptors. It could explain the possible association between posterior reversible encephalopathy syndrome and COVID-19 | ||
| 650 | 4 | |a Case Reports | |
| 650 | 4 | |a English Abstract | |
| 650 | 4 | |a COVID-19 | |
| 650 | 4 | |a Encephalopathy | |
| 650 | 4 | |a Endothelial dysfunction | |
| 650 | 4 | |a Epilepsy | |
| 650 | 4 | |a Posterior reversible encephalopathy syndrome | |
| 700 | 1 | |a Tauler Redondo, M P |e verfasserin |4 aut | |
| 700 | 1 | |a Garví López, M |e verfasserin |4 aut | |
| 700 | 1 | |a Lozano Serrano, M B |e verfasserin |4 aut | |
| 700 | 1 | |a López-Torres López, J |e verfasserin |4 aut | |
| 700 | 1 | |a Sánchez López, M L |e verfasserin |4 aut | |
| 773 | 0 | 8 | |i Enthalten in |t Revista espanola de anestesiologia y reanimacion |d 1967 |g 70(2023), 1 vom: 03. Jan., Seite 51-55 |w (DE-627)NLM00018750X |x 2340-3284 |7 nnns |
| 773 | 1 | 8 | |g volume:70 |g year:2023 |g number:1 |g day:03 |g month:01 |g pages:51-55 |
| 856 | 4 | 0 | |u http://dx.doi.org/10.1016/j.redar.2021.05.022 |3 Volltext |
| 912 | |a GBV_USEFLAG_A | ||
| 912 | |a GBV_NLM | ||
| 951 | |a AR | ||
| 952 | |d 70 |j 2023 |e 1 |b 03 |c 01 |h 51-55 | ||