Progressive Cytopenia Developing during Treatment of Cryptococcosis in a Patient with HIV Infection and Bone Marrow Cryptococcal Infection
Cytopenia is a common complication in patients with human immunodeficiency virus (HIV) infection. Identifying the cause is demanding because of the wide range of possible diagnoses. We herein report an HIV-infected patient with disseminated cryptococcosis involving multiple organs including the blood, brain, lungs, and bone marrow, who developed progressive pancytopenia after initiation of anti-fungal treatment with liposomal amphotericin-B (L-AMB) and flucytosine (5FC). The pancytopenia persisted despite early 5FC discontinuation. A bone marrow biopsy revealed cryptococcal infiltration and the blood examination findings recovered quickly after resuming L-AMB. Thus, this HIV-infected patient's pathological findings and clinical course suggested that the primary cause of the pancytopenia was bone marrow cryptococcosis.
| Medienart: |
E-Artikel |
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| Erscheinungsjahr: |
2022 |
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| Erschienen: |
2022 |
| Enthalten in: |
Zur Gesamtaufnahme - volume:61 |
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| Enthalten in: |
Internal medicine (Tokyo, Japan) - 61(2022), 2 vom: 15. Jan., Seite 257-261 |
| Sprache: |
Englisch |
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| Beteiligte Personen: |
Katsura, Mai [VerfasserIn] |
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| Links: |
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| Themen: |
Adrenal insufficiency |
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| Anmerkungen: |
Date Completed 18.01.2022 Date Revised 10.03.2022 published: Print-Electronic Citation Status MEDLINE |
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| doi: |
10.2169/internalmedicine.7282-21 |
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| funding: |
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| Förderinstitution / Projekttitel: |
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| PPN (Katalog-ID): |
NLM328791075 |
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| 500 | |a Citation Status MEDLINE | ||
| 520 | |a Cytopenia is a common complication in patients with human immunodeficiency virus (HIV) infection. Identifying the cause is demanding because of the wide range of possible diagnoses. We herein report an HIV-infected patient with disseminated cryptococcosis involving multiple organs including the blood, brain, lungs, and bone marrow, who developed progressive pancytopenia after initiation of anti-fungal treatment with liposomal amphotericin-B (L-AMB) and flucytosine (5FC). The pancytopenia persisted despite early 5FC discontinuation. A bone marrow biopsy revealed cryptococcal infiltration and the blood examination findings recovered quickly after resuming L-AMB. Thus, this HIV-infected patient's pathological findings and clinical course suggested that the primary cause of the pancytopenia was bone marrow cryptococcosis | ||
| 650 | 4 | |a Journal Article | |
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| 650 | 4 | |a adrenal insufficiency | |
| 650 | 4 | |a cytopenia | |
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| 700 | 1 | |a Okuhama, Ayako |e verfasserin |4 aut | |
| 700 | 1 | |a Koizumi, Yoshiki |e verfasserin |4 aut | |
| 700 | 1 | |a Ando, Naokatsu |e verfasserin |4 aut | |
| 700 | 1 | |a Yanagawa, Yasuaki |e verfasserin |4 aut | |
| 700 | 1 | |a Mizushima, Daisuke |e verfasserin |4 aut | |
| 700 | 1 | |a Aoki, Takahiro |e verfasserin |4 aut | |
| 700 | 1 | |a Tsukada, Kunihisa |e verfasserin |4 aut | |
| 700 | 1 | |a Teruya, Katsuji |e verfasserin |4 aut | |
| 700 | 1 | |a Kikuchi, Yoshimi |e verfasserin |4 aut | |
| 700 | 1 | |a Oka, Shinichi |e verfasserin |4 aut | |
| 700 | 1 | |a Watanabe, Koji |e verfasserin |4 aut | |
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